[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655252":3},{"organization":4,"outcomesModule":7,"designInfo":31,"detailedDescription":34,"studyPopulation":35,"armGroups":36,"interventions":30,"overallOfficials":30,"centralContacts":40,"locations":47,"responsibleParty":63,"collaborators":67,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":30,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":30,"maxAge":30,"enrollmentInfo":77,"targetDuration":30,"studyType":80,"phases":30,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":50,"whyStopped":30,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University of Valencia","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":30},[9],{"measure":10,"description":11,"timeFrame":12},"Change in corrected carotid artery flow (ccFT) in association with cardiorespiratory changes and volume expansion during lung resection surgery","Doppler ultrasonography measurements are performed repeatedly at following timepoints: awake (seated), awake (supine), after intubation, after lateral decubitus position, after transition to one-lung ventilation, after pleura opening, after carbon dioxide insufflation, before lung recruitment, after first highest PEEP, after second highest PEEP, after optimal PEEP, before and after volume expansion.\n\nStatistical analysis: within-patient change (Friedman, Wilcoxon signed rank), correlation","enrollment phase (up to 2 years)",[14,17,21,24,27],{"measure":15,"description":16,"timeFrame":12},"Diagnostic accuracy of corrected carotid flow time (ccFT) and recruitment - induced change in carotid corrected flow time (delta ccFTRM) in discriminating fluid responders during one-lung ventilation","Corrected carotid flow time (ccFT) is measured by Doppler ultrasonography immediately before volume expansion (VE) and 5 min after it.\n\nRecruitment - induced change in carotid corrected flow time (delta cFTRM) is calculated from measurments obtained by Doppler utrasonography immediately before recruitment maneuver (RM) and at highest PEEP.\n\ndelta ccFTRM = (ccFT before RM - ccFTafter RM) \u002F ccFT before RM\n\nFluid response is defined as \\> 15% increase in cardiac output (CO) following volume expansion (VE). Volume expansion is a 200-250 ml bolus of crystalloid solution performed after the recruitment maneuver (RM) at the discretion of attending anesthesiologist. Measurements are obtained by pulse contour analysis after immediately before volume expansion (VE) and 5 min after it.\n\nStat- ROC curve\n\nOutcome measure - prognostic ability (AUC)of corrected carotid flow time (ccFT) and recruitment - induced change in carotid corrected flow time (delta ccFTRM) in predicting CO increase.",{"measure":18,"description":19,"timeFrame":20},"Diagnostic accuracy of baseline preoperative carotid flow time (ccFT) in discriminating between poor and good tolerance to recruitment maneuver and preoperative position-induced change in ccFT in discriminating fluid responders and non-responders.","Baseline preoperative carotid corrected flow time (ccFT) is a preoperative carotid Doppler measurement in seated position.\n\nPosition-induced change (delta ccFT-P) is calculated from measurments obtained by Doppler utrasonography in awake seated position and within approxiamtely 10-15 minutes in awake supine position.\n\ndelta ccFTP = (ccFT awake seated - ccFTawake supine ) \u002F ccFT awake seated\n\nPoor tolerance to lung recruitment is defined as TWA-MAP of 20% decrease from baseline or absolute value \\\u003C 65 mmHg measured during recruitment period or 10 min after. Measurements are obtained by pulse contour analysis from immediately before recruitment maneuver to 5 min after it.\n\nFluid response is defined as \\> 15% increase in cardiac output (CO) following volume expansion (VE). Volume expansion(VE) is a 200-250 ml bolus of crystalloid solution performed after the recruitment maneuver (RM) at discretion of attending anesthesiologist.","enrollment phase (up to 2 years); statistical analysis (ROC); outcome measure - prognostic ability (AUC) of preoperative corrected carotid flow time (ccFT) and position - induced change in ccFT (delta ccFTRM) in predicting poor tolerance or CO increase",{"measure":22,"description":23,"timeFrame":12},"Change in cerebral blood volume index (CBVIl, CBVIr) in association with cardiorespiratory changes and volume expansion during lung resection surgery","Doppler ultrasonography measurements are performed repeatedly at following timepoints: awake (seated), awake (supine), after intubation, after lateral decubitus position, after transition to one-lung ventilation, after pleura opening, after carbon dioxide insufflation, before lung recruitment, after first highest PEEP, after second highest PEEP, after optimal PEEP, before and after volume expansion.\n\nStatistical analysis: within-patient change (Friedman, Wilcoxon signed rank), correlation (with cardiac output)",{"measure":25,"description":26,"timeFrame":12},"Change in secondary hemodynamic and ventilatory variables in response to cardiorespiratory changes and volume expansion during lung resection surgery","Hemodynamic variables (CO, SV, MAP, HR, dP\u002Fdt, Eadyn, PI, BIS, carotid diameter, resistivity index) are obtained from pulse contour analysis\u002F Doppler and respiratory variables (EtCO2, Ppeak, PEEP, TV, SpO2, FiO2, RR) are obtained from mechanical ventilator continuously during the same timepoints as primary variable.\n\nOutcome measure: all variables will be taken and reported at the following timepoints: awake (seated), awake (supine), after intubation, after lateral decubitus position, after transition to one-lung ventilation, after pleura opening, after carbon dioxide insufflation, before lung recruitment, after first highest PEEP, after second highest PEEP, after optimal PEEP, before and after volume expansion.\n\nStatistical analysis: within-patient change (Friedman, Wilcoxon signed rank), correlation",{"measure":28,"description":29,"timeFrame":12},"Comparative between-group analysis of primary and secondary variables in patients of different sex, ventilation protocol, operative side, recruitment tolerance and fluid response.","Hemodynamic (CO, SV, MAP, HR, dP\u002Fdt, Eadyn, PI, BIS, carotid diameter, resistivity index) are obtained from pulse contour analysis\u002F Doppler and respiratory variables (EtCO2, Ppeak, PEEP, TV, SpO2, FiO2, RR) will be collected at following timepoints: awake (seated), awake (supine), after intubation, after lateral decubitus position, after transition to one-lung ventilation, after pleura opening, after carbon dioxide insufflation, before lung recruitment, after first highest PEEP, after second highest PEEP, after optimal PEEP, before and after volume expansion. Comparative between-group analysis of variables response will be performed. Groups are stratified by sex, ventilation protocol, operative side, recruitment tolerance and fluid response. Statistical analysis: between-patient change (Mann-Whitney).",null,{"allocation":30,"interventionModel":30,"interventionModelDescription":30,"primaryPurpose":30,"observationalModel":32,"timePerspective":33,"maskingInfo":30},"COHORT","PROSPECTIVE","In this study investigators look at intraoperative trajectory of secondary variables (hemodynamic and ventilatory) during cardiorespiratory changes and volume expansion to provide clinical context for primary variable response. A comparative analysis of all variables is performed in patients with different sex, ventilation protocol, operative side, tolerance to recruitment and fluid responsiveness.","Surgical population",[37],{"label":38,"type":30,"description":39,"interventionNames":30},"Longitudinal study","Repeated measurements design",[41],{"name":42,"role":43,"phone":44,"phoneExt":45,"email":46},"Manuel Granell Gil Prof.","CONTACT","609232031","+34","margry@uv.es",[48],{"facility":49,"status":50,"city":51,"state":30,"zip":30,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Hospital General Valencia","RECRUITING","Valencia","Spain","ES",{"type":55,"coordinates":56},"Point",[57,58],-0.37966,39.47391,{"lat":58,"lon":57},[61],{"name":62,"role":43,"phone":44,"phoneExt":45,"email":46},"Prof. Manuel Granell, Dr",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Manuel Vicente Granell Gil","Associate Professor of Medicine",[68],{"name":49,"class":6},"100655252","effect-of-cardiorespiratory-changes-on-carotid-flow-time-during-lung-resection-surgery-100655252",false,"NCT07808749","Effect of Cardiorespiratory Changes on Carotid Flow Time During Lung Resection Surgery","Noninvasive Perioperative Hemodynamic Monitoring In Thoracic Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* patients scheduled to undergo thoracosocpic lung resection surgery\n\nExclusion Criteria:\n\n* carotid stenosis or abnormal anatomy of carotid artery that prevents visualization, emphysema, arrythmia","ALL",{"count":78,"type":79},50,"ESTIMATED","OBSERVATIONAL","Cardiorespiratory changes during lung resection surgery, even though generally well tolerated, may lead to hemodynamic compromise, reducing venous return to the heart and hence cardiac output.\n\nCarotid corrected flow time is widely regarded as non-invasive index of preload status, yet its dynamic relationship with cardiac output, especially in surgical population is not well-studied. Understanding how cardiorespiratory changes affect carotid flow time in anesthesized patients remains limited. This study investigates corrected carotid flow time response to anesthesia, lateral position, one-lung ventilation, open chest, capnothorax, lung recruitment and volume expansion, hypothesizing that cFT declines in association with CO reduction during lung resection.\n\nThe secondary interest of the study is to test whether carotid flow time and its recruitment-induced change can adequately predict fluid response during one-lung ventilation. In addition, the baseline preoperative carotid flow time and its position-induced change are studied as potential predictors of hemodynamic tolerance to lung recruitment and fluid response, respectively.\n\nFinally, the purpose of this study is to see if cardiorespiratory changes and volume expansion affect cerebral blood volume during lung resection surgery.",[83],"Hemodynamic Monitoring",[85,86],"carotid, cerebral circulation","hemodynamic instability","2026-09-01",{"date":89,"type":90},"2026-09-09","ACTUAL",{"date":92,"type":90},"2025-01-27",{"date":94,"type":79},"2027-03-15",{"name":5,"class":6},1]