[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624910":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":25,"centralContacts":29,"locations":34,"responsibleParty":50,"collaborators":20,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":20,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":20,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":75,"whyStopped":20,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Transcranial Magnetic Stimulation","A MagVenture MagPro 100X stimulator with a B91 figure-8 coil will be used for the TMS\u002FfMRI rTMS sessions. Motor threshold testing will be done outside of the scanner using a separate MagVenture MagPro 100X with a separate B65 coil.",[12,13],"Device: Active TMS","Device: Sham TMS",[15,21],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Active TMS","Subjects will receive a continuous 1800 pulse cTBS train to the right dlPFC at 100% of motor threshold. The train will consist of 50 Hz bursts, repeated at intervals of 200 ms (5 Hz) for 40 sec.",[9],null,{"type":16,"name":22,"description":23,"armGroupLabels":24,"otherNames":20},"Sham TMS","Subjects will receive a series of 100 single pulses to the right dlPFC at 100% of motor threshold. Pulses will be randomly jittered and have an average interpulse interval of 6 ± 4 seconds. Single pulses delivered in such a fashion have been shown to have little or no neuromodulatory effect on subsequent cortical excitability.",[9],[26],{"name":27,"affiliation":5,"role":28},"Nicholas Balderston, PhD","PRINCIPAL_INVESTIGATOR",[30],{"name":27,"role":31,"phone":32,"phoneExt":20,"email":33},"CONTACT","12157463058","nicholas.balderston@pennmedicine.upenn.edu",[35],{"facility":5,"status":20,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Philadelphia","Pennsylvania","19104-6013","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-75.16362,39.95238,{"lat":45,"lon":44},[48],{"name":27,"role":31,"phone":49,"phoneExt":20,"email":33},"215-746-3058",{"type":51,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100624910","effect-of-ctbs-on-startle-and-tms-evoked-bold-100624910",false,"NCT07415772","Effect of cTBS on Startle and TMS-evoked BOLD","The Effect of Right dlPFC cTBS on Acute Measures of Anxiety, Functional Connectivity, and TMS-evoked BOLD Responses.","Inclusion Criteria:\n\n* Able to give their consent\n* Right-handed\n* Individuals receiving therapy for anxiety must be stable on their regimen for at least 4 weeks prior to study enrollment.\n\nExclusion Criteria:\n\n* Non-english speaking\n* Any significant medical or neurological problems\n* Current or past non-anxiety-related psychiatric comorbidity, active or history of active suicidal ideation\n* Alcohol\u002Fdrug problems in the past year or lifetime alcohol or drug dependence\n* Medications that act on the central nervous system\n* History of seizure\n* History of epilepsy\n* Increased risk of seizure for any reason\n* Pregnancy, or positive pregnancy test\n* Any medical condition that increases risk for fMRI or TMS\n* Any metal in their body which would make having an MRI scan unsafe\n* Any sort of medical implants\n* Hearing loss\n* Claustrophobia\n* orthostatic hypotension",true,"ALL","18 Years","50 Years",{"count":64,"type":65},140,"ESTIMATED","INTERVENTIONAL",[68],"NA","The right dorsolateral prefrontal cortex (dlPFC) is increasingly being targeted with transcranial magnetic stimulation (TMS) to reduce anxiety expression; however, there is little mechanistic evidence supporting an optimized treatment protocol. Thus, the objective of the current project is to develop an interleaved TMS\u002FfMRI that can assess the effect of neuromodulatory (potentially therapeutic) TMS protocols on neural and behavioral measures related to anxiety expression. PUBLIC HEALTH RELEVANCE: These results will yield direct evidence that 1 Hz and cTBS modulate brain activity associated with anxiety expression and regulation, thus informing novel TMS based anxiety treatments.",[71],"Anxiety",[73,74],"anxiety","transcranial magnetic stimulation","NOT_YET_RECRUITING","2026-08-07",{"date":78,"type":79},"2026-08-10","ACTUAL",{"date":81,"type":65},"2026-09-01",{"date":83,"type":65},"2031-06-30",{"name":5,"class":6},1]