[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650806":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":22,"centralContacts":39,"locations":49,"responsibleParty":63,"collaborators":22,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":22,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":22,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":91,"whyStopped":22,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Foundation University Islamabad","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental 1: Self-Etch Adhesive","EXPERIMENTAL","Self- Etch Adhesive",[13],"Combination Product: Self-etch adhesive",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","PLACEBO_COMPARATOR","Conventional bonding technique",[19],"Combination Product: Conventional Bonding Technique",{"label":21,"type":10,"description":22,"interventionNames":23},"Experimental group 2: One-Step Adhesive",null,[24],"Combination Product: One-Step Adhesive",[26,31,35],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"COMBINATION_PRODUCT","Self-etch adhesive","Self-Etch adhesive used for two step bonding of bracket placement.",[9],{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":22},"One-Step Adhesive","Placement of bracket using one-step adhesive system.",[21],{"type":27,"name":36,"description":37,"armGroupLabels":38,"otherNames":22},"Conventional Bonding Technique","Bonding brackets using three step conventional technique; etchant , bonding agent, composite adhesive",[15],[40,45],{"name":41,"role":42,"phone":43,"phoneExt":22,"email":44},"Emaan Ahsin","CONTACT","92 3065843663","emaan.ahsin@fui.edu.pk",{"name":46,"role":42,"phone":47,"phoneExt":22,"email":48},"Rozina Nazir","923215376612","rozina.nazir@fui.edu.pk",[50],{"facility":51,"status":22,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":22},"Foundation University College of Dentistry and Hospital","Islamabad","Federal","44000","Pakistan","PK",{"type":58,"coordinates":59},"Point",[60,61],73.04329,33.72148,{"lat":61,"lon":60},{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Shoaib Rahim","Associate Professor","100650806","effect-of-different-adhesive-systems-on-white-spot-lesions-during-fixed-orthodontic-treatment-100650806",false,"NCT07753512","Effect of Different Adhesive Systems on White Spot Lesions During Fixed Orthodontic Treatment","Effect of Different Adhesive Systems on White Spot Lesions During Fixed Orthodontic Treatment: A Split Mouth Randomized Controlled Trial","Inclusion Criteria:\n\n* healthy patients 12-30 yrs\n* patients undergoing fixed appliance treatment with full mouth bonding\n* presence of at least 7 accessible teeth\n* no cavitated lesion at time of bond up\n\nExclusion Criteria:\n\n* patients with chronic or systematic diseases\n* patients with fluorosis or enamel defects\n* presence of fixed prosthesis\n* patients on medications which could alter salivary flow\n* patients with history of salivary gland disease",true,"ALL","12 Years","30 Years",{"count":79,"type":80},34,"ESTIMATED","INTERVENTIONAL",[83],"NA","The primary goal of this study is to compare the number of white spot lesions during fixed appliance therapy between self-etch and one-step bonding systems.",[86,87],"Malaligned Teeth","Crowding of Teeth",[89,90],"white spot lesions","orthodontic adhesives","NOT_YET_RECRUITING","2026-08-06",{"date":94,"type":95},"2026-08-10","ACTUAL",{"date":97,"type":80},"2027-01-15",{"date":99,"type":80},"2028-06-15",{"name":5,"class":6},1]