[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652531":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":54,"collaborators":26,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":26,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":26,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Shifa College of Dentistry","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Healed Socket Group (Control Group)","ACTIVE_COMPARATOR","Maxillary first premolars will be extracted before or within one week of fixed orthodontic appliance placement. Participants will subsequetly undergo leveling and alignment followed by en-masse anterior retraction after stabilization on a 0.019 x 0.025-inch stainless steel archwire.",[13],"Procedure: Early Maxillary First Premolar Extraction",{"label":15,"type":16,"description":17,"interventionNames":18},"Unhealed Socket Group (Intervention Group)","EXPERIMENTAL","Maxillary first premolars will be extracted after the participant has completed leveling and alignment, and has been stabilizad on a 0.019 x 0.025-inch stainless steel archwire for one month. This will be followed immediately by en-masse anterior retraction.",[19],"Procedure: Late Maxillary First Premolar Extraction",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Early Maxillary First Premolar Extraction","Bilateral extraction of the maxillary first premolars will be performed prior to or within one week of fixed orthodontic appliance placement, allowing the extraction sockets to heal during leveling and alignment before commencement of en-masse anterior retraction.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Late Maxillary First Premolar Extraction","Bilateral extraction of the maxillary first premolars will be performed after completion of leveling and alignment and one month of stabilization on a 0.019 × 0.025-inch stainless steel archwire, immediately before commencement of en-masse anterior retraction.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Shanzay Khan, BDS, Post Graduate Resident","CONTACT","03245555716","shanzaykhan1997@gmail.com",[38],{"facility":39,"status":40,"city":41,"state":26,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Shifa College Of Dentistry","RECRUITING","Islamabad","44000","Pakistan","PK",{"type":46,"coordinates":47},"Point",[48,49],73.04329,33.72148,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":35,"phoneExt":26,"email":36},"Shanzay Khan",{"type":55,"investigatorFullName":53,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Postgraduate Resident in Orthodontics","100652531","effect-of-early-versus-late-premolar-extraction-on-orthodontic-tooth-movement-100652531",false,"NCT07773389","Effect of Early Versus Late Premolar Extraction on Orthodontic Tooth Movement","Effect of Early vs Late Premolar Extraction on the Rate of Orthodontic Tooth Movement: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age 13-25 years\n2. No prior orthodontic treatment\n3. Overjet 4-8 mm\n4. Symmetric dental arches with mild to moderate crowding requiring bilateral first premolar extractions.\n5. Probing depth less than 4 mm on all teeth\n\nExclusion Criteria:\n\n1. History of dental trauma\n2. Poor oral hygiene\n3. Syndromic patients\n4. Systemic diseases or medications affecting bone metabolism","ALL","13 Years","25 Years",{"count":68,"type":69},26,"ESTIMATED","INTERVENTIONAL",[72],"NA","The goal of this randomized controlled trial is to evaluate whether the timing of premolar extraction affects the rate of orthodontic space closure during en-masse anterior retraction. The study will also assess gingival cleft formation, mesial movement of the upper first molars, ease and duration of premolar extraction, and patient-reported pain and anxiety.\n\nThe main question it aims to answer is:\n\nDoes early versus late premolar extraction affect the rate of orthodontic space closure?\n\nResearchers will compare two groups of patients. In the early extraction group the maxillary first premolars will be extracted before or within one week of start of fixed orthodontic treatment. In the late extraction group, the premolars will be extracted after alignment and immediately before the start of space closure.\n\nParticipants will:\n\n* Receive fixed orthodontic treatment and bilateral extraction of the maxillary first premolars.\n* Be randomly assigned to either the early-extraction or late-extraction group.\n* Undergo orthodontic alignment followed by en-masse anterior retraction.\n* Have dental impressions\u002Fdigital models obtained at the start of retraction and at 3 and 6 months to measure orthodontic tooth movement and space closure.\n* Be assessed for gingival clefts and mesial movement of the upper first molars.\n* Have the ease and duration of their premolar extraction recorded and report their pain and anxiety associated with the extraction procedure.",[75,76],"Malocclusion Class II","Malocclusion, Angle Class I",[78,79,80,81,82,83,84,85],"Orthodontic Tooth movement","Premolar extraction","Early Extraction","Late Extraction","Orthodontic Space Closure","En-masse anterior retraction","Gingival Cleft","Anchorage loss","2026-08-15",{"date":88,"type":89},"2026-08-19","ACTUAL",{"date":91,"type":89},"2026-07-22",{"date":93,"type":69},"2028-06",{"name":5,"class":6},1]