[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652161":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":24,"locations":11,"responsibleParty":30,"collaborators":11,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":36,"sex":42,"minAge":11,"maxAge":11,"enrollmentInfo":43,"targetDuration":11,"studyType":46,"phases":47,"briefSummary":49,"conditions":50,"keywords":53,"overallStatus":56,"whyStopped":11,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":11},{"fullName":5,"class":6},"Cukurova University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Title: GLP-1 Receptor Agonist Group","ACTIVE_COMPARATOR",null,[13],"Procedure: non-surgical periodontal therapy",{"label":15,"type":16,"description":11,"interventionNames":17},"Control Group","PLACEBO_COMPARATOR",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"PROCEDURE","non-surgical periodontal therapy","All participants will receive oral hygiene instructions, including instruction in the modified Bass toothbrushing technique. Non-surgical periodontal therapy will be performed under local anesthesia in two sessions and will include full-mouth subgingival instrumentation and scaling and root planing using ultrasonic instruments and Gracey curettes. No adjunctive antimicrobial agents will be used.",[15,9],[25],{"name":26,"role":27,"phone":28,"phoneExt":11,"email":29},"bahar alkaya","CONTACT","+05368720327","balkaya@cu.edu.tr",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","BAHAR ALKAYA","ASSOCIATE PROFESSOR","100652161","effect-of-glp-1-receptor-agonists-on-periodontal-health-and-response-to-nonsurgical-periodontal-therapy-100652161",false,"NCT07770906","Effect of GLP-1 Receptor Agonists on Periodontal Health and Response to Nonsurgical Periodontal Therapy","Effect of Glucagon-Like Peptide-1 Receptor Agonist Use on Periodontal Health and Response to Non-Surgical Periodontal Therapy","GLP1-PERIO","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Body mass index (BMI) ≥25 kg\u002Fm²\n* Presence of at least 20 functional teeth\n* Diagnosis of periodontitis\n* For the GLP-1 receptor agonist group: regular use of a GLP-1 receptor agonist for at least 3 months\n\nExclusion Criteria:\n\n* Age between 18 and 65 years\n* Body mass index (BMI) ≥25 kg\u002Fm²\n* Presence of at least 20 functional teeth\n* Diagnosis of periodontitis\n* For the GLP-1 receptor agonist group: regular use of a GLP-1 receptor agonist for at least 3 months","ALL",{"count":44,"type":45},40,"ESTIMATED","INTERVENTIONAL",[48],"NA","This study aims to evaluate the effects of glucagon-like peptide-1 receptor agonist (GLP-1 RA) use on periodontal health and the response to non-surgical periodontal therapy in individuals with obesity and periodontitis.\n\nParticipants with obesity and periodontitis will be divided into two groups: those who have been using a GLP-1 RA for at least 3 months and those who are not using any medication for obesity. All participants will receive the same non-surgical periodontal treatment, including oral hygiene instruction, scaling, and root planing.\n\nPeriodontal clinical measurements and gingival crevicular fluid samples will be collected before treatment and at 3 and 6 months after treatment. The study will compare changes in periodontal health and inflammatory markers between the two groups to determine whether GLP-1 RA use is associated with periodontal health and the response to non-surgical periodontal therapy.",[51,52],"Periodontal Disease","Obesity & Overweight",[54,55],"PERIODONTAL DISEASE","OBESİTY","NOT_YET_RECRUITING","2026-08-18",{"date":59,"type":60},"2026-08-20","ACTUAL",{"date":62,"type":45},"2026-09-01",{"date":64,"type":45},"2027-12-01",{"name":5,"class":6}]