[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648441":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":26,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":26,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":26,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":79,"whyStopped":26,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Peking University People's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High-Oxygen Group (FiO₂=100%)","ACTIVE_COMPARATOR","FiO₂=100% throughout one-lung ventilation.",[13],"Procedure: High inspired oxygen concentration (FiO₂=100%) during one-lung ventilaion",{"label":15,"type":16,"description":17,"interventionNames":18},"Low-Oxygen Group (FiO₂=50%)","EXPERIMENTAL","Initial FiO₂=50% during one-lung ventilation (maintaining SpO₂≥92%) with individualized PEEP titration. If SpO₂\\\u003C92%, increase FiO₂ by 10% increments; if SpO₂\\\u003C90% and FiO₂ already at 100%, initiate rescue ventilation.",[19],"Procedure: Low inspired oxygen concentration (FiO₂=50%) during one-lung ventilation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Low inspired oxygen concentration (FiO₂=50%) during one-lung ventilation","Ventilation with initial FiO₂=50% during one-lung ventilation, combined with individualized PEEP titration. Oxygen concentration is dynamically adjusted based on SpO₂; ventilation duration at each FiO₂ level and total oxygen exposure burden are recorded.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"High inspired oxygen concentration (FiO₂=100%) during one-lung ventilaion","Ventilation with FiO₂=100% throughout one-lung ventilation, combined with individualized PEEP titration (decremental PEEP titration selecting the highest PEEP corresponding to the lowest driving pressure).",[9],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Yi Feng, Ph.D","CONTACT","010-88325590","doc_yifeng@163.com",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":26},"Department of Anesthesiology, Peking University People's Hospital","Beijing","Beijing Municipality","100000","China","CN",{"type":46,"coordinates":47},"Point",[48,49],116.39723,39.9075,{"lat":49,"lon":48},{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Yi Feng, MD","Director of Anesthesiology","100648441","effect-of-inspired-oxygen-concentration-on-postoperative-atelectasis-after-vats-right-lobectomy-100648441",false,"NCT07721558","Effect of Inspired Oxygen Concentration on Postoperative Atelectasis After VATS Lobectomy","Effect of Inspired Oxygen Concentration on Postoperative Atelectasis in Patients Undergoing Elective Thoracoscopic Pulmonary Lobectomy Based on Perioperative Lung Protection Strategy: A Randomized Controlled Trial","Inclusion Criteria:\n\nAge 18-65 years Elective thoracoscopic (VATS) pulmonary lobectomy Anticipated one-lung ventilation duration \\>1 hour ASA physical status I-III\n\nExclusion Criteria:\n\nPrevious pulmonary surgery (including lobectomy, lung volume reduction surgery, or other lung resection) Pre-existing significant atelectasis (large collapse on preoperative CT) Contraindications to PEEP: intracranial hypertension, bronchopleural fistula, hypovolemic shock, right heart failure, giant bullae, pneumothorax Preoperative continuous oxygen therapy or mechanical ventilation, moderate-severe COPD BMI ≥ 30 kg\u002Fm² Ischemic cardiovascular and cerebrovascular diseases, such as myocardial infarction, ischemic stroke, and patients with coronary or cerebrovascular stents Patient refusal to participate\n\nWithdrawal Criteria \u002F Major Protocol Deviations:\n\nSurgery changed to simple wedge resection Severe pleural adhesions (found intraoperatively) One-lung ventilation duration \\\u003C 50 minutes Intraoperative blood loss \\> 500 ml Severe hypotension (MAP \\\u003C 55 mmHg despite high-dose vasopressors) Unexpected non-thoracic surgical procedure Ventilation protocol interrupted (e.g., FiO₂ exposure \\\u003C 80% of planned time in the low-oxygen group) Postoperative CT not completed or image quality unusable Subject withdrawal of informed consent","ALL","18 Years","65 Years",{"count":66,"type":67},100,"ESTIMATED","INTERVENTIONAL",[70],"NA","This study aims to investigate whether using 50% FiO₂ during one-lung ventilation, compared with 100% FiO₂, reduces postoperative atelectasis in the non-dependent (healthy) lung of patients undergoing VATS pulmonary lobectomy, based on individualized PEEP titration. This is a single-center, prospective, assessor- and patient-blinded randomized controlled trial. A total of 100 patients (50 per group, including a pilot phase of 10 per group) will be enrolled and randomized 1:1 to the high-oxygen group (FiO₂=100%) and the low-oxygen group (FiO₂=50%). The primary endpoint is the percentage of atelectasis volume in the non-operated lung relative to the total non-operated lung volume, assessed by CT at 60±10 minutes after tracheal extubation.",[73,74],"Atelectasis","Postoperative Pulmonary Complications",[76,77,78],"Inspired oxygen concentration","One-lung ventilation","Lung recruitment maneuver","NOT_YET_RECRUITING","2026-08-16",{"date":82,"type":83},"2026-08-19","ACTUAL",{"date":85,"type":67},"2026-09-01",{"date":87,"type":67},"2027-12-01",{"name":5,"class":6},1]