[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646498":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":26,"responsibleParty":31,"collaborators":35,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":26,"eligibilityCriteria":44,"healthyVolunteers":45,"sex":46,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":26,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":67,"whyStopped":26,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":26},{"fullName":5,"class":6},"Wageningen University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Neutral Knee Position","ACTIVE_COMPARATOR","Participants in this group wear a knee brace in full extension (0°) for five consecutive days.",[13],"Device: Knee immobilization brace (0°) for 5 days",{"label":15,"type":16,"description":17,"interventionNames":18},"Flexed Knee Position","EXPERIMENTAL","Participants in this group wear a knee brace in flexion (60°) for five consecutive days.",[19],"Device: Knee immobilization brace (60°) for 5 days",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Knee immobilization brace (0°) for 5 days","Unilateral knee immobilization at 0° flexion for 5 days using a brace; post-immobilization metabolic testing with tracer infusions and biopsies",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Knee immobilization brace (60°) for 5 days","Unilateral knee immobilization at 60° flexion for 5 days using a brace; post-immobilization metabolic testing with tracer infusions and biopsies",[15],{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Marlou Dirks","Principal Investigator",[36],{"name":37,"class":6},"ZonMw: The Netherlands Organisation for Health Research and Development","100646498","effect-of-knee-position-on-muscle-loss-during-leg-immobilization-100646498",false,"NCT07690150","Effect of Knee Position on Muscle Loss During Leg Immobilization","A Novel Angle: Manipulating Knee Position to Understand Muscle Deterioration During Leg Immobilization","Inclusion Criteria:\n\n* Healthy males and females\n* Aged from 18-40 years at the time of signing informed consent\n* 18.5 \\\u003C BMI \\\u003C 30 kg·m-2\n* Must be willing and able to communicate and participate in the whole study\n\nExclusion Criteria:\n\n* Smoking\n* Diabetes (Type 1, Type 2, or genetic form of diabetes)\n* Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and\u002For ≥90 mmHg diastolic)\n* Chronic use of any prescribed or over the counter pharmaceuticals that may modulate muscle protein metabolism (excluding oral contraceptives and contraceptive devices).\n* A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.\n* Prone to keloid forming (i.e. hyperplastic growth of scars).\n* Any known disorders in muscle metabolism\n* Regular use of dietary protein and\u002For amino acid supplements (\\>3 times per week)\n* Currently involved in a structured progressive resistance training programme (\\>3 times per week)\n* Known allergy to lidocaine\n* Known severe kidney problems\n* Allergy to one or multiple amino acids\n* Recent (within the last 6 months) or current musculoskeletal injury (e.g. leg fracture)\n* Having received or ingested a stable isotope tracer containing 15N in the past\n* Contra-indications for MRI such as incompatible metal objects in the body and claustrophobia.\n* Currently taking part in other scientific research\n* Pregnant or breastfeeding\n* Unable to give consent",true,"ALL","18 Years","40 Years",{"count":50,"type":51},30,"ESTIMATED","INTERVENTIONAL",[54],"NA","This study looks at what happens to leg muscles when the knee is kept straight or bent during five days of wearing a brace. We want to find out if keeping the knee bent (so the thigh muscle is stretched) helps prevent muscle loss compared to keeping the knee straight. Thirty healthy adults will take part. They will wear a knee brace for five days and have several tests before and after, including scans, blood samples, and small muscle samples. The results may help doctors find better ways to protect muscles when people cannot move, for example after surgery or illness.",[57,58,59],"Muscle Atrophy","Disuse Atrophy","Immobilization",[61,62,63,64,65,66],"Quadriceps","Knee Brace","Muscle Protein Breakdown","Dynamometry","Stable Isotope Tracers","MRI","NOT_YET_RECRUITING","2026-07-01",{"date":70,"type":71},"2026-07-08","ACTUAL",{"date":73,"type":51},"2026-08-01",{"date":75,"type":51},"2028-06-01",{"name":5,"class":6}]