[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652771":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":39,"responsibleParty":58,"collaborators":25,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":86,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Clinique Saint-Luc","NETWORK",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"LPP then CP","EXPERIMENTAL","Participants undergo baseline measurements without cervical pressure, followed by left paratracheal pressure (LPP) at 30 N for 45 seconds, a 60-second washout period, and then cricoid pressure (CP) at 30 N for 45 seconds.",[13,14],"Procedure: Left Paratracheal Pressure","Procedure: Cricoid Pressure",{"label":16,"type":10,"description":17,"interventionNames":18},"CP then LPP","Participants undergo baseline measurements without cervical pressure, followed by cricoid pressure (CP) at 30 N for 45 seconds, a 60-second washout period, and then left paratracheal pressure (LPP) at 30 N for 45 seconds.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Left Paratracheal Pressure","A standardized cricoid pressure of 30 N will be applied for 45 seconds using a calibrated force-measuring device. Regional cerebral oxygen saturation, hemodynamic variables, and respiratory variables will be continuously recorded during the intervention.",[16,9],null,{"type":21,"name":27,"description":23,"armGroupLabels":28,"otherNames":25},"Cricoid Pressure",[16,9],[30],{"name":31,"affiliation":32,"role":33},"Benjamin Javillier, MD","Clinique Saint-Luc Bouge","PRINCIPAL_INVESTIGATOR",[35],{"name":31,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","+32 81 20 91 55","javillier.benjamin@hotmail.com",[40],{"facility":32,"status":25,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Bouge","Namur","5004","Belgium","BE",{"type":47,"coordinates":48},"Point",[49,50],4.89218,50.47193,{"lat":50,"lon":49},[53,54,55],{"name":31,"role":36,"phone":37,"phoneExt":25,"email":38},{"name":31,"role":33,"phone":25,"phoneExt":25,"email":25},{"name":56,"role":57,"phone":25,"phoneExt":25,"email":25},"Eric Deflandre, MD, PhD","SUB_INVESTIGATOR",{"type":59,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100652771","effect-of-left-paratracheal-pressure-on-cerebral-oxygenation-during-general-anesthesia-100652771",false,"NCT07778303","Effect of Left Paratracheal Pressure on Cerebral Oxygenation During General Anesthesia","Prospective Randomized Crossover Study of the Effect of Left Paratracheal Pressure on Regional Cerebral Oxygenation Measured by Near-Infrared Spectroscopy During General Anesthesia Induction","PARANIRS","Inclusion Criteria:\n\n* Age ≥18 years\n* Scheduled for elective surgery requiring general anesthesia with orotracheal intubation\n* American Society of Anesthesiologists (ASA) physical status I to III\n* Ability to understand the study information\n* Written informed consent obtained before study procedures\n\nExclusion Criteria:\n\n* Refusal to participate\n* Known or suspected pregnancy\n* Emergency surgery\n* Inability to provide informed consent\n* History of stroke or transient ischemic attack within the previous 6 months\n* Known severe carotid artery stenosis (\\>70%) or previous carotid surgery\n* Known intracranial hypertension\n* Cervical malformation or previous cervical surgery preventing correct application of left paratracheal pressure or cricoid pressure\n* Technical inability to correctly position the NIRS sensors\n* Any condition considered by the investigator to be incompatible with study participation",true,"ALL","18 Years","99 Years",{"count":73,"type":74},70,"ESTIMATED","INTERVENTIONAL",[77],"NA","Left paratracheal pressure (LPP) has been proposed as an alternative to cricoid pressure to reduce the risk of regurgitation during induction of general anesthesia. Previous studies suggest that LPP can effectively compress the esophagus without significantly reducing left carotid blood flow. However, its effect on cerebral oxygenation has not yet been evaluated.\n\nThe aim of this prospective randomized crossover study is to assess whether application of LPP affects regional cerebral oxygen saturation measured by near-infrared spectroscopy (NIRS) during general anesthesia.\n\nSeventy adult patients undergoing elective surgery under general anesthesia with tracheal intubation will be included. After induction of anesthesia and stabilization, cerebral oxygen saturation will be continuously measured under three conditions: no cervical pressure, left paratracheal pressure at 30 N, and cricoid pressure at 30 N. The order of the two pressure maneuvers will be randomized.\n\nThe primary objective is to determine the change in left regional cerebral oxygen saturation during LPP compared with baseline without cervical pressure.",[80],"Cerebral Oxygenation",[22,27,82,83,84,85],"Near-Infrared Spectroscopy","NIRS","Regional Cerebral Oxygen Saturation","General Anesthesia","NOT_YET_RECRUITING","2026-08-18",{"date":89,"type":90},"2026-08-21","ACTUAL",{"date":92,"type":74},"2026-10-15",{"date":94,"type":74},"2027-06",{"name":5,"class":6},1]