[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650410":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":42,"responsibleParty":52,"collaborators":26,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":26,"eligibilityCriteria":61,"healthyVolunteers":58,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":26,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":82,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Allied Hospital Faisalabad","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Bupivacaine Infiltration Plus Standard Care","EXPERIMENTAL","Participants undergoing elective laparoscopic abdominal surgery will receive pre-incisional infiltration of 20 mL of 0.5% bupivacaine diluted with 20 mL of normal saline (final concentration 0.25%). The solution will be equally infiltrated into the planned trocar insertion sites before skin incision in addition to standard perioperative care.",[13,14],"Drug: Bupivacaine","Other: Standard Perioperative Analgesia",{"label":16,"type":17,"description":18,"interventionNames":19},"Standard Care","ACTIVE_COMPARATOR","Participants undergoing elective laparoscopic abdominal surgery will receive standard perioperative care and postoperative analgesia without local bupivacaine infiltration at the trocar insertion sites.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Bupivacaine","Bupivacaine 0.5% (5 mg\u002FmL), 20 mL diluted with 20 mL of normal saline to achieve a final concentration of 0.25% (40 mL total volume). The solution will be infiltrated equally into the planned laparoscopic trocar insertion sites before skin incision.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Standard Perioperative Analgesia","Standard perioperative analgesia according to the institutional protocol, including intravenous paracetamol 1 g every 8 hours and intravenous tramadol 50 mg administered as rescue analgesia for patients with a Visual Analog Scale (VAS) pain score ≥4 during the first 24 hours after surgery.",[9,16],[32],{"name":33,"affiliation":34,"role":35},"Muhammad Akram, MBBS, FCPS General Surgery","Department of General Surgery, Allied Hospital, Faisalabad, Pakistan","STUDY_CHAIR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Jawad Qamar, MBBS","CONTACT","+923060403567","jawadqamar22@gmail.com",[43],{"facility":5,"status":26,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":26,"geoPoint":26,"contacts":49},"Faisalābad","Punjab Province","38000","Pakistan","PK",[50],{"name":38,"role":39,"phone":51,"phoneExt":26,"email":41},"00923060403567",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Jawad Qamar","Postgraduate resident","100650410","effect-of-local-anesthetic-infiltration-for-postoperative-pain-control-in-laparoscopic-abdominal-surgery-a-prospective-randomized-study-100650410",false,"NCT07747584","Effect of Local Anesthetic Infiltration for Postoperative Pain Control in Laparoscopic Abdominal Surgery: A Prospective Randomized Study","Inclusion Criteria:\n\nAdults aged 18 to 60 years. Scheduled for elective laparoscopic abdominal surgery (e.g., cholecystectomy, appendectomy, or hernia repair).\n\nAmerican Society of Anesthesiologists (ASA) physical status I or II. Able to understand and use the Visual Analog Scale (VAS) for pain assessment. Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\nIntraoperative conversion to open laparotomy. Known allergy, hypersensitivity, or contraindication to bupivacaine or other amide local anesthetics.\n\nPregnancy or breastfeeding. History of chronic pain syndromes or regular use of opioid or non-opioid analgesics before surgery.\n\nHistory of substance abuse or severe psychiatric disorders that may affect pain perception.\n\nLocal skin infection at the planned trocar insertion sites.","ALL","18 Years","60 Years",{"count":66,"type":67},166,"ESTIMATED","INTERVENTIONAL",[70],"NA","Brief Summary\n\nPostoperative pain remains a common problem after laparoscopic abdominal surgery despite the minimally invasive nature of these procedures. Pain mainly arises from the trocar insertion sites, tissue manipulation, and the effects of pneumoperitoneum. Although systemic analgesics are routinely used, they may not provide adequate pain relief and can be associated with adverse effects.\n\nThis prospective randomized controlled trial aims to evaluate whether pre-incisional infiltration of bupivacaine at laparoscopic trocar insertion sites reduces postoperative pain compared with standard care without local anesthetic infiltration. A total of 166 adult patients undergoing elective laparoscopic abdominal surgery will be randomly assigned to receive either local bupivacaine infiltration before skin incision or no local anesthetic infiltration. All participants will receive the same standard perioperative care and postoperative analgesic regimen.\n\nThe primary outcome is postoperative pain intensity measured using the Visual Analog Scale (VAS) during the first 24 hours after surgery. Secondary outcomes include the time to first rescue analgesic, total opioid consumption within the first 24 hours, and overall postoperative pain control. The results of this study may help determine whether local bupivacaine infiltration is an effective, simple, and low-cost addition to multimodal analgesia for patients undergoing laparoscopic abdominal surgery.",[73],"Postoperative Pain",[73,75,76,23,77,78,79,80,81],"Laparoscopic Surgery","Laparoscopic Abdominal Surgery","Local Anesthetic Infiltration","Trocar Site Infiltration","Multimodal Analgesia","Visual Analog Scale","Opioid Consumption","NOT_YET_RECRUITING","2026-07-31",{"date":85,"type":86},"2026-08-05","ACTUAL",{"date":88,"type":67},"2026-08",{"date":90,"type":67},"2027-01",{"name":5,"class":6},1]