[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652506":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":26,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":26,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":26,"enrollmentInfo":65,"targetDuration":26,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":79,"whyStopped":26,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Samsung Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mechanical power-based lung protective ventilation group","EXPERIMENTAL","Patients in this group will receive the mechanical power-based lung-protective ventilation strategy during one-lung ventilation.",[13],"Procedure: Mechanical power-based lung protective ventilation",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional ventilation group","ACTIVE_COMPARATOR","Patients in this group will receive the conventional lung-protective ventilation strategy during one-lung ventilation.",[19],"Procedure: Conventional lung protective ventilation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Mechanical power-based lung protective ventilation","Initial Settings\n\n1\\) Tidal Volume: 4-6 mL\u002Fkg of predicted body weight 2) Positive End-Expiratory Pressure: Set to the value that minimizes driving pressure 3) Respiratory Rate: Adjusted to maintain an end-tidal carbon dioxide of 35-45 mmHg Protocol\n\n1. If mechanical power exceeds 7 J\u002Fmin, decrease the respiratory rate by 1 and reduce the tidal volume by 5%, then maintain these settings for 1 minute.\n2. If mechanical power remains above 7 J\u002Fmin after 1 minute, further decrease the respiratory rate by 1 and reduce the tidal volume by an additional 5%, then maintain for 1 minute.\n3. If end-tidal carbon dioxide exceeds 50 mmHg, perform arterial blood gas analysis to check arterial pH.\n4. If arterial pH drops below 7.2, the intervention will be discontinued, and the patient will be withdrawn from the study and treated with conventional treatment.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Conventional lung protective ventilation","Ventilator Settings\n\n* Tidal Volume: 4-6 mL\u002Fkg of predicted body weight\n* Positive End-Expiratory Pressure: 5 cmH2O\n* Respiratory Rate: Adjusted to maintain an end-tidal carbon dioxide of 35-45 mmHg",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Heejoon Jeong Anesthesiologist, Professor, MD","CONTACT","+82-2-3410-0841","heejoonjeong@skku.edu",[38],{"facility":5,"status":26,"city":39,"state":26,"zip":40,"country":41,"countryCode":26,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Seoul","06351","South Korea",{"type":43,"coordinates":44},"Point",[45,46],126.9784,37.566,{"lat":46,"lon":45},[49,50],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"name":51,"role":52,"phone":26,"phoneExt":26,"email":26},"Heejoon Jeong, MD","PRINCIPAL_INVESTIGATOR",{"type":52,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Heejoon Jeong","Anesthesiologist, Professor","100652506","effect-of-mechanical-power-based-lung-protective-ventilation-during-one-lung-ventilation-100652506",false,"NCT07772804","Effect of Mechanical Power-based Lung-protective Ventilation During One-lung Ventilation","Incidence of Postoperative Pulmonary Complications Between Mechanical Power-based Versus Conventional Lung Protective Ventilation During One-lung Ventilation: a Randomized Controlled Trial","Inclusion Criteria\n\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Elective thoracic surgery requiring lung lobectomy under one-lung ventilation\n* Age 18 years or older\n* Written informed consent obtained from the patient\n\nExclusion Criteria\n\n* Prior history of thoracic surgery\n* Emergency surgery\n* Pregnancy or lactation\n* Known contraindication to one-lung ventilation\n* Inability to provide informed consent or cooperate with the study protocol","ALL","19 Years",{"count":66,"type":67},164,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this clinical trial is to determine whether a mechanical power-based lung-protective ventilation strategy during one-lung ventilation reduces the incidence of postoperative pulmonary complications in adult patients undergoing lung resection surgery.\n\nMechanical power during pressure-regulated volume control mode is calculated using the formula below.\n\nMechanical power (J\u002Fmin) = 0.098 x respiratory rate x tidal volume x (inspiratory airway pressure above positive end-expiratory pressure + positive end-expiratory pressure)\n\nThe main questions it aims to answer are:\n\n* Does a mechanical power-based lung-protective ventilation strategy significantly lower the incidence of major postoperative pulmonary complications compared to conventional ventilation?\n* How does this strategy impact intraoperative hemodynamic and vital profiles (e.g., blood pressure, cardiac output, vasopressor requirements, and blood oxygen saturation) during one-lung ventilation?\n\nParticipants will:\n\n* Be randomized to receive either a mechanical power-based lung-protective ventilation strategy or a conventional lung-protective ventilation strategy exclusively during one-lung ventilation.\n* Be closely monitored for the occurrence of major postoperative pulmonary complications (atelectasis, pneumonia, acute respiratory distress syndrome, and pulmonary aspiration) and adverse events for 1 month postoperatively.",[73,74],"Lung Cancer (Diagnosis)","Pulmonary Complications in Surgical Patients",[76,77,78],"mechanical power","lung protective ventilation","postoperative pulmonary complication","NOT_YET_RECRUITING","2026-08-14",{"date":82,"type":83},"2026-08-19","ACTUAL",{"date":85,"type":67},"2026-08-30",{"date":87,"type":67},"2027-09-30",{"name":5,"class":6},1]