[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643222":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":20,"studyPopulation":20,"armGroups":29,"interventions":40,"overallOfficials":20,"centralContacts":46,"locations":52,"responsibleParty":63,"collaborators":20,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":20,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":20,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":20,"overallStatus":85,"whyStopped":20,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Baghdad","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":20,"otherOutcomes":20},[9,13,17],{"measure":10,"description":11,"timeFrame":12},"Change in Fatigue Severity Score","Assessment of the effectiveness of a medication adherence-based digital intervention on fatigue severity by using the Fatigue Severity Scale (FSS).","Baseline and 3 months after intervention",{"measure":14,"description":15,"timeFrame":16},"Change in Body Weight","Assessment of the effectiveness of a medication adherence-based digital intervention on weight by assessment of changes in Body Mass Index (BMI), calculated as weight in kilograms divided by height in meters squared (kg\u002Fm²).","Baseline and 3 months after intervention.",{"measure":18,"description":19,"timeFrame":16},"Change in Thyroid Hormone Levels","Assessment of the effectiveness of a medication adherence-based digital intervention on Thyroid Hormone Levels by assessment of serum Thyroid Stimulating Hormone (TSH) and Free Thyroxine (FT4) levels.",null,{"allocation":22,"interventionModel":23,"interventionModelDescription":20,"primaryPurpose":24,"observationalModel":20,"timePerspective":20,"maskingInfo":25},"RANDOMIZED","PARALLEL","SUPPORTIVE_CARE",{"masking":26,"maskingDescription":20,"whoMasked":27},"SINGLE",[28],"PARTICIPANT",[30,34],{"label":31,"type":32,"description":33,"interventionNames":20},"Control Group","NO_INTERVENTION","receive routine care",{"label":35,"type":36,"description":37,"interventionNames":38},"Intervention Group","EXPERIMENTAL","participants in the intervention group will receive digital support aimed at improving their adherence to prescribed medications. This support will include a smartphone application developed specifically for the study, as well as reminder messages via WhatsApp to prompt participants to take their levothyroxine at the scheduled times",[39],"Other: medication adherence based digital intervention",[41],{"type":6,"name":42,"description":37,"armGroupLabels":43,"otherNames":44},"medication adherence based digital intervention",[35],[45],"intervntion group",[47],{"name":48,"role":49,"phone":50,"phoneExt":20,"email":51},"Shahad Sabah Khudhair","CONTACT","9647737721360","shahed.sabbah1202a@conursing.uobaghdad.edu.iq",[53],{"facility":5,"status":20,"city":54,"state":20,"zip":20,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":20},"Baghdad","Iraq","IQ",{"type":58,"coordinates":59},"Point",[60,61],44.40088,33.34058,{"lat":61,"lon":60},{"type":64,"investigatorFullName":48,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","PhD Student","100643222","effect-of-medication-adherence-based-digital-intervention-on-fatigue-severity-weight-and-thyroid-hormone-regulation-100643222",false,"NCT07636681","Effect of Medication Adherence-Based Digital Intervention on Fatigue Severity, Weight, and Thyroid Hormone Regulation","Effect of Medication Adherence-Based Digital Intervention on Fatigue Severity, Weight, and Thyroid Hormone Regulation in Patients With Hypothyroidism: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults (≥18 years) with primary hypothyroidism.\n* On stable levothyroxine therapy for at least 3 months.\n* Able to read, understand study instructions\n* capable of using basic mobile applications\n* poor medication adherence, clinically significant fatigue, documented weight fluctuations and abnormal thyroid hormone\n\nExclusion Criteria:\n\n* Secondary hypothyroidism or recent thyroidectomy\u002Fradioactive iodine therapy.\n* Pregnancy or breastfeeding woman.\n* Severe psychiatric disorders or cognitive impairment\n* significant visual or hearing deficits\n* Serious comorbidities affecting medication adherence (e.g., chronic disease, renal, or hepatic disease).\n* take dietary supplements or medications that interfere with levothyroxine absorption.","ALL","18 Years","60 Years",{"count":77,"type":78},80,"ESTIMATED","INTERVENTIONAL",[81],"NA","1. To evaluate the effect of a medication adherence-based digital intervention on fatigue severity in patients with hypothyroidism.\n2. To assess the effect of a medication adherence-based digital intervention on weight in patients with hypothyroidism.\n3. To investigate the effect of a medication adherence-based digital intervention on thyroid hormone regulation in patients with hypothyroidism.",[84],"Hypothyroidism","NOT_YET_RECRUITING","2026-06-03",{"date":88,"type":89},"2026-06-09","ACTUAL",{"date":91,"type":78},"2026-06-01",{"date":93,"type":78},"2026-12-30",{"name":5,"class":6},1]