[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646865":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":26,"responsibleParty":38,"collaborators":26,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":26,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":26,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":26,"overallStatus":61,"whyStopped":26,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":26},{"fullName":5,"class":6},"China-Japan Friendship Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","PLACEBO_COMPARATOR","Participants in this group will only receive an 8-week pulmonary rehabilitation training program and two placebo capsules daily for 8 weeks.",[13],"Behavioral: Pulmonary rehabilitation training",{"label":15,"type":16,"description":17,"interventionNames":18},"Interventional group","EXPERIMENTAL","Participants in this group will receive an 8-week pulmonary rehabilitation training program combined with an astaxanthin dietary supplement.",[19,13],"Dietary Supplement: Astaxanthin",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Astaxanthin","Two capsules of astaxanthin formula supplement daily for 8 weeks.",[15],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"BEHAVIORAL","Pulmonary rehabilitation training","A total of 8 weeks, 2-3 times per week. 1) Patient education: once a week, including disease explanation, chronic disease self-management awareness, and medication guidance. 2) Exercise training: 60 minutes each time, including 10 minutes of warm-up exercise, 40 minutes of aerobic exercise, and 10 minutes of stretching and relaxation (monitoring participants' working frequency, SpO2, heart rate, dyspnea score, and leg fatigue during exercise). 3) 20-min lower extremity endurance training (treadmill walking or treadmill exercise at 60% of 6MWT speed). 4) 20 minutes of lower limb strength training: squats, jump rope, straight leg raising exercises, etc.",[9,15],[33],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"Mingming Deng","CONTACT","86 18801336854","isdeng1017@163.com",{"type":39,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Gang Hou","Principal Investigator","100646865","effect-of-oral-astaxanthin-formula-on-pulmonary-rehabilitation-in-patients-with-copd-100646865",false,"NCT07684391","Effect of Oral Astaxanthin Formula on Pulmonary Rehabilitation in Patients With COPD","Effect of Oral Astaxanthin Formula Supplement on Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease: a Multicenter, Randomized Controlled Study","Inclusion Criteria:\n\n* Patients who met the GOLD diagnostic criteria for stage II-IV COPD\n* Patients who met the indications for pulmonary rehabilitation training: mMRC score\n\n  * 3 or self-reported decline in physical function.\n\nExclusion Criteria:\n\n* Hypoxemia (resting partial pressure of oxygen \\\u003C 60mmHg or oxygen saturation \\\u003C 88%) or patients requiring continuous oxygen therapy or with any contraindications to exercise testing (refer to the American Society of Thoracic Surgeons\u002FAmerican College of Chest Physicians exercise testing guidelines).\n* Using oral glucocorticoids\n* Long-term oxygen therapy\n* Participated in a supervised exercise program within the past 12 months\n* History of other pulmonary diseases, including pneumoconiosis, bronchiectasis, tuberculosis, primary pulmonary hypertension, pulmonary embolism, interstitial lung disease\n* Skeletal, neuromuscular, cardiovascular, or metabolic disorders that limit the participant's ability to exercise actively or that involve muscle activity, such as cancer, diabetes, muscle weakness, etc.","ALL","18 Years","80 Years",{"count":53,"type":54},140,"ESTIMATED","INTERVENTIONAL",[57],"NA","The goal of this clinical trial is to investigate whether an astaxanthin-based dietary supplement combined with a pulmonary rehabilitation training program could improve exercise capacity in patients with COPD. The main questions it aims to answer are:\n\n• whether an astaxanthin-based dietary supplement combined with a pulmonary rehabilitation training program could improve 6MWD in patients with COPD.\n\nThe drug administration group will receive:\n\n* Two capsules of astaxanthin formula supplement daily for 8 weeks.\n* Pulmonary rehabilitation training: a total of 8 weeks, 2-3 times a week.\n\nThe control group will receive a total of 8-week pulmonary rehabilitation training, 2-3 times a week.\n\nThe investigators will compare the drug administration group and the control group to see if the difference between the 2 groups reaches a minimal clinically important difference.",[60],"COPD","NOT_YET_RECRUITING","2026-06-29",{"date":64,"type":65},"2026-07-06","ACTUAL",{"date":67,"type":54},"2026-07-01",{"date":69,"type":54},"2026-12-31",{"name":5,"class":6}]