[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648136":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":35,"responsibleParty":49,"collaborators":11,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":11,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":11,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":37,"whyStopped":11,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"General Hospital of Ningxia Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pretreated Rocuronium Group","EXPERIMENTAL",null,[13],"Drug: Rocuronium Bromide (Pretreatment Injection)",{"label":15,"type":16,"description":11,"interventionNames":17},"Conventional Administration Group","ACTIVE_COMPARATOR",[18],"Drug: Rocuronium Bromide (Conventional Injection)",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","Rocuronium Bromide (Pretreatment Injection)","Low-dose rocuronium bromide is injected intravenously in advance before anesthesia induction",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Rocuronium Bromide (Conventional Injection)","Rocuronium bromide is administered by standard routine intravenous injection during anesthesia induction",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"xiaoya chen","CONTACT","8618295266516","chenxiaoya0314@163.com",[36],{"facility":5,"status":37,"city":38,"state":11,"zip":11,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Yinchuan","China","CN",{"type":42,"coordinates":43},"Point",[44,45],106.27306,38.46806,{"lat":45,"lon":44},[48],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},{"type":50,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100648136","effect-of-pre-injection-of-rocuronium-on-neuromuscular-blockade-onset-time-and-hemodynamics-during-general-anesthesia-induction-100648136",false,"NCT07716891","Effect of Pre-injection of Rocuronium on Neuromuscular Blockade Onset Time and Hemodynamics During General Anesthesia Induction","Inclusion Criteria:\n\n* Aged from 18 to 65 years old\n* American Society of Anesthesiologists (ASA) physical status classification Ⅰ, Ⅱ or Ⅲ\n* Elective surgery requiring general anesthesia with tracheal intubation\n* Able to understand the study and voluntarily sign written informed consent\n* Male or female, no gender restriction\n\nExclusion Criteria:\n\n* Severe hepatic dysfunction (ALT\u002FAST \\> 3 times the upper limit of normal) or renal dysfunction (creatinine \\> 2 times the upper limit of normal)\n* Central nervous system diseases or severe neuromuscular disorders\n* Severe arrhythmia or cardiac dysfunction (NYHA class Ⅲ-Ⅳ, or ejection fraction EF \\\u003C 30%)\n* Known hypersensitivity or allergy to rocuronium, midazolam, propofol or other study-related drugs\n* Refusal to participate in this clinical trial\n* Pregnant or breastfeeding women\n* History of predicted difficult airway requiring awake tracheal intubation\n* Contraindications to rapid sequence induction",true,"ALL","18 Years","65 Years",{"count":62,"type":63},108,"ESTIMATED","INTERVENTIONAL",[66],"NA","This is a single-center, prospective, randomized, controlled trial comparing pre-injection versus standard bolus administration of rocuronium bromide for general anesthesia induction. A total of 108 adult patients (18-65 years, ASA I-III) scheduled for elective surgery requiring endotracheal intubation will be enrolled and randomized 1:1 to either the pre-injection group or control group.\n\nThe pre-injection group will receive rocuronium 0.06 mg\u002Fkg as a priming dose followed by 0.54 mg\u002Fkg 3 minutes later. The control group will receive rocuronium 0.6 mg\u002Fkg as a single bolus. All patients will receive standardized anesthesia induction with midazolam and propofol.\n\nThe primary outcome is neuromuscular blockade onset time (seconds). Secondary outcomes include hemodynamic parameters (SBP, DBP, MAP, HR, CO, SV, SVR), injection pain incidence, and adverse events.\n\nThis study aims to investigate whether pre-injection of rocuronium can shorten neuromuscular blockade onset time while maintaining hemodynamic stability compared to standard bolus administration.",[69,70],"General Anesthesia","Elective Surgery",[72,73,74],"Rocuronium bromide","Onset time","Hemodynamics","2026-07-16",{"date":77,"type":78},"2026-07-21","ACTUAL",{"date":80,"type":63},"2026-07",{"date":82,"type":63},"2026-12",{"name":5,"class":6},1]