[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648044":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":40,"responsibleParty":61,"collaborators":63,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":26,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":95,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Maastricht University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Probiotic supplement","EXPERIMENTAL","6g of probiotic supplement daily",[13],"Dietary Supplement: Probiotic supplementation",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","6g of placebo daily",[19],"Other: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Probiotic supplementation","16-week consumption of 6 g\u002Fday of probiotic supplement",[9],null,{"type":6,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"16-week consumption of 6 g\u002Fday of placebo",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"Tanja Adam, PhD","CONTACT","+31433882123","t.adam@maastrichtuniversity.nl",{"name":37,"role":33,"phone":38,"phoneExt":26,"email":39},"Iris Boelen, MSc","+31433883644","iris.boelen@maastrichtuniversity.nl",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Maastricht University, Department of Nutrition and Movement Sciences","RECRUITING","Maastricht","Limburg","6200MD","Netherlands","NL",{"type":50,"coordinates":51},"Point",[52,53],5.68889,50.84833,{"lat":53,"lon":52},[56,57,59],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},{"name":37,"role":33,"phone":58,"phoneExt":26,"email":39},"+31 (0)433883644",{"name":32,"role":60,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"type":62,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[64],{"name":65,"class":66},"Winclove Probiotics B.V.","INDUSTRY","100648044","effect-of-probiotics-on-appetite-regulation-in-adults-with-overweightobesity-100648044",false,"NCT07715955","Effect of Probiotics on Appetite Regulation in Adults With Overweight\u002FObesity","Probiotic Regulation of Food Intake Through Satiety Stimulation and Gut Microbiota Modulation","ProBiSat","Inclusion Criteria:\n\n* Men and women, aged between 20-70 years\n* BMI ³ 25 kg\u002Fm2\n* Stable body weight (weight gain or loss \\\u003C 3 kg in the past three months)\n* Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study\n* No difficult venipuncture as evidenced during the screening visit\n\nExclusion Criteria:\n\n* Diabetic patients (type 1 and type 2)\n* Abuse of drugs\n* More than 2 units alcoholic consumptions per day for women and 3 for men\n* Use of products or dietary supplements known to interfere with the main outcomes 3 months prior to the start of the study as judged by the principal investigators\n* Gastrointestinal disease (including IBD and IBS)\n* Use of an investigational product within another biomedical intervention trial within the previous 1-month\n* Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, autoimmune disease and rheumatoid arthritis\n* Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident\n* use of lipid- and glucose lowering medication, corticosteroid use\n* Psychiatric diagnoses including clinical depression\n* Intolerances or dietary habits that might interfere with the study (i.e. lactose intolerance or veganism)\n* pregnancy\n* smoking, vaping\n* use of antibiotics up to 3 months prior to the study",true,"ALL","20 Years","70 Years",{"count":80,"type":81},98,"ESTIMATED","INTERVENTIONAL",[84],"NA","The goal of this 16-week randomised, placebo-controlled parallel study is to investigate the effect of a newly formed probiotic supplement on satiety and gut microbiota composition in healthy men and women with overweight or obesity form 20-70 years old. The main question it aims to answer is:\n\nDoes the probiotic supplement increase feelings of satiety and alter gut microbiota composition?\n\nParticipants will:\n\n* Receive a daily dose of 6 g probiotic supplement (packed in sachets of 3 g) or placebo for 16 weeks.\n* Visit the research unit 3 times at baseline, week 8 and week 16 of the intervention for blood draws and delivering fecal samples.\n* Keep a study diary to report deviations from their daily habits and fill in food questionnaires.",[87,88,89,90,91,92,93,94],"Healthy","Overweight (BMI > 25)","Overweight , Obesity","Male","Female","Adults","Satiety and Food Intake","Gut Microbiota Modulation",[96,97,98,92,87,99,100,101,102,103],"Probiotics","Overweight","Obesity","Satiety","Food intake","Gut microbiota","Gut microbiota composition","Gut microbiota modulation","2026-08-10",{"date":106,"type":107},"2026-08-12","ACTUAL",{"date":109,"type":107},"2026-03-18",{"date":111,"type":81},"2029-08-18",{"name":5,"class":6},1]