[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597828":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":22,"studyPopulation":22,"armGroups":35,"interventions":53,"overallOfficials":22,"centralContacts":64,"locations":70,"responsibleParty":98,"collaborators":100,"id":106,"slug":107,"hasResults":108,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":22,"eligibilityCriteria":112,"healthyVolunteers":108,"sex":113,"minAge":114,"maxAge":22,"enrollmentInfo":115,"targetDuration":22,"studyType":118,"phases":119,"briefSummary":121,"conditions":122,"keywords":124,"overallStatus":73,"whyStopped":22,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":136},{"fullName":5,"class":6},"Eastern Switzerland University of Applied Sciences","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":22},[9],{"measure":10,"description":11,"timeFrame":12},"1. Change in Rrs (Respiratory System Resistance) before and after rehabilitation cycle","Rrs will be measured using the forced oscillation technique (FOT) in cmH₂O·s\u002FL. Values will be assessed before and after the pulmonary rehabilitation cycle at moderate altitude","baseline to 3 weeks",[14,17,20],{"measure":15,"description":16,"timeFrame":12},"Change in Xrs (Respiratory System Reactance) compared before and after the pulmonary rehabilitation.","Xrs will be measured using FOT in cmH₂O·s\u002FL. Values will be compared before and after the pulmonary rehabilitation",{"measure":18,"description":19,"timeFrame":12},"Change in ∆Xrs (Difference in Reactance) before and after rehabilitation","∆Xrs will be calculated as the difference between inspiratory and expiratory Xrs values, measured in cmH₂O·s\u002FL, before and after rehabilitation.",{"measure":21,"description":22,"timeFrame":23},"Change in Rrs, Xrs and ∆Xrs from low to moderate altitude",null,"From baseline at low altitude to transfer to moderate altitude at 3 days",{"allocation":25,"interventionModel":26,"interventionModelDescription":22,"primaryPurpose":27,"observationalModel":22,"timePerspective":22,"maskingInfo":28},"RANDOMIZED","SEQUENTIAL","TREATMENT",{"masking":29,"maskingDescription":22,"whoMasked":30},"QUADRUPLE",[31,32,33,34],"PARTICIPANT","CARE_PROVIDER","INVESTIGATOR","OUTCOMES_ASSESSOR",[36,42,48],{"label":37,"type":38,"description":39,"interventionNames":40},"Normoxia","SHAM_COMPARATOR","Sham air (ambient air) (5l\u002Fmin) will be applied with the oxygen concentrator EverFlo TM via nasal cannula",[41],"Other: ambiant air",{"label":43,"type":44,"description":45,"interventionNames":46},"Hyperoxia","ACTIVE_COMPARATOR","Standardized supplemental oxygen therapy (SSOT) at 5 L\u002Fmin will be delivered using the EverFlo™ oxygen concentrator via nasal cannula during training.",[47],"Other: Oxygen",{"label":49,"type":50,"description":51,"interventionNames":52},"Hypoxia","EXPERIMENTAL","This group will train at moderate altitude",[41],[54,58,62],{"type":6,"name":55,"description":56,"armGroupLabels":57,"otherNames":22},"ambiant air","Standard ambiant air will be breathed during endurance training. ambiant air",[49],{"type":6,"name":59,"description":60,"armGroupLabels":61,"otherNames":22},"Oxygen","SSOT and sham air (5l\u002Fmin) will be applied with the oxygen concentrator EverFloTM via nasal cannula during training",[43],{"type":6,"name":55,"description":56,"armGroupLabels":63,"otherNames":22},[37],[65],{"name":66,"role":67,"phone":68,"phoneExt":22,"email":69},"Stéphanie Saxer, Dr.","CONTACT","+41 58 257 12 97","stephanie.saxer@ost.ch",[71,86],{"facility":72,"status":73,"city":74,"state":75,"zip":22,"country":75,"countryCode":76,"cosmosGeoPoint":77,"geoPoint":82,"contacts":83},"National center for cardiology and internal medicine","RECRUITING","Bishkek","Kyrgyzstan","KG",{"type":78,"coordinates":79},"Point",[80,81],74.59,42.87,{"lat":81,"lon":80},[84],{"name":85,"role":67,"phone":22,"phoneExt":22,"email":22},"Talant Sooronbaev, Prof.",{"facility":5,"status":87,"city":88,"state":89,"zip":90,"country":91,"countryCode":92,"cosmosGeoPoint":93,"geoPoint":97,"contacts":22},"ACTIVE_NOT_RECRUITING","Sankt Gallen","Canton of St. Gallen","9000","Switzerland","CH",{"type":78,"coordinates":94},[95,96],9.37477,47.42391,{"lat":96,"lon":95},{"type":99,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR",[101,104],{"name":102,"class":103},"National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov","OTHER_GOV",{"name":105,"class":6},"University of Zurich","100597828","effect-of-rehabilitation-at-moderate-altitude-on-airway-resistance-measured-with-forced-oscillation-technique-in-copd-patients-100597828",false,"NCT07063563","Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in COPD-patients","Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in Patients With COPD","Inclusion Criteria:\n\n* Aged ≥18 years\n* Stable clinical condition for \\>3 weeks (e.g., no exacerbations)\n* Resting SpO₂ ≥88% and exercise-induced hypoxemia defined as a drop in SpO₂ of ≥4% and\u002For a level below 90% during the 6MWT\n* Informed consent documented by signature\n\nExclusion Criteria:\n\n* Severe daytime resting hypoxemia (SpO₂ \\\u003C88%)\n* Long-term oxygen therapy\n* Unstable clinical condition requiring adjustment of pharmacological or other treatment modalities, need for intensive care, or presence of relevant severe comorbidities\n* Inability to comply with study procedures (e.g., due to language barriers, psychological disorders, neurological or orthopedic impairments, walking disability, or inability to ride a bicycle)\n* Women who are pregnant or breastfeeding\n* Enrolment in another clinical trial involving active treatment","ALL","18 Years",{"count":116,"type":117},52,"ESTIMATED","INTERVENTIONAL",[120],"NA","Airway resistance will be measured using the forced oscillation technique (FOT). The parameters Rrs, Xrs, and ∆Xrs will be compared before and after a pulmonary rehabilitation cycle at moderate altitude. Additionally, the differences between low and moderate altitude will also be examined.",[123],"COPD",[59,125,126],"Exercise","Rehabilitation","2025-07-16",{"date":129,"type":130},"2025-07-20","ACTUAL",{"date":132,"type":117},"2025-07-23",{"date":134,"type":117},"2025-12-31",{"name":5,"class":6},2]