[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656440":3},{"organization":4,"outcomesModule":7,"designInfo":35,"detailedDescription":44,"studyPopulation":34,"armGroups":45,"interventions":66,"overallOfficials":34,"centralContacts":34,"locations":76,"responsibleParty":96,"collaborators":34,"id":100,"slug":101,"hasResults":102,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":34,"eligibilityCriteria":105,"healthyVolunteers":102,"sex":106,"minAge":107,"maxAge":34,"enrollmentInfo":108,"targetDuration":34,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":119,"overallStatus":79,"whyStopped":34,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":34},[9],{"measure":10,"description":11,"timeFrame":12},"Postoperative Pain Score at the Specimen Extraction Site","Evaluated using the Numeric Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst possible pain).","Postoperative 8th hour.",[14,18,22,26,30],{"measure":15,"description":16,"timeFrame":17},"Postoperative Pain Scores at Subsequent Time Points","Postoperative regional pain assessed at the specimen extraction site and non-extraction port sites using the Numeric Rating Scale (NRS), which ranges from 0 (no pain) to 10 (worst possible pain)","Postoperative 2th, 4th, 12th, and 24th hours.",{"measure":19,"description":20,"timeFrame":21},"Total Postoperative Analgesic Consumption","The total amount of rescue analgesic medication (specifically the cumulative dose of tramadol\u002Fcontramal required by the patient) administered during the first 24 hours after surgery.","Postoperative 24 hours",{"measure":23,"description":24,"timeFrame":25},"Length of Hospital Stay","The total duration of the patient's hospitalization, measured from the time of admission to the general surgery ward post-surgery until the time of official hospital discharge.","From postoperative admission to the general surgery ward until hospital discharge.",{"measure":27,"description":28,"timeFrame":29},"Operative Duration","The total surgical duration, measured in minutes from the initial skin incision to final wound closure.","From initial skin incision to final wound closure (intraoperatively).",{"measure":31,"description":32,"timeFrame":33},"Total Intraoperative Insufflation Gas Volume","The total volume of carbon dioxide gas used for pneumoperitoneum throughout the surgical procedure, recorded in liters from the insufflator device.","From initiation of pneumoperitoneum until completion of the surgical procedure.",null,{"allocation":36,"interventionModel":37,"interventionModelDescription":34,"primaryPurpose":38,"observationalModel":34,"timePerspective":34,"maskingInfo":39},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":40,"maskingDescription":34,"whoMasked":41},"DOUBLE",[42,43],"PARTICIPANT","OUTCOMES_ASSESSOR","The purpose of this prospective, randomized clinical trial is to investigate the clinical impact of two different specimen extraction sites (periumbilical versus left lower quadrant) on postoperative pain. Additionally, the study evaluates the efficacy of routine preemptive local anesthesia infiltration at all trocar sites. Patients undergoing laparoscopic appendectomy are randomly allocated into four parallel groups based on the extraction site and the administration of local anesthesia. The primary objective is to compare local and regional pain scores at the extraction and non-extraction port sites, assessed via the Numeric Rating Scale (NRS) at the 2nd, 4th, 8th, 12th, and 24th postoperative hours. Secondary outcomes include total postoperative analgesic consumption, operative duration, length of hospital stay.\"",[46,52,56,62],{"label":47,"type":48,"description":49,"interventionNames":50},"Left Lower Quadrant Extraction - Local Anesthesia","EXPERIMENTAL","Specimen is extracted from the left lower quadrant port. Local anesthesia infiltration is applied to all port sites.",[51],"Drug: Port-site local anesthesia infiltration",{"label":53,"type":48,"description":54,"interventionNames":55},"Periumbilical Extraction - Local Anesthesia","Specimen is extracted from the periumblical port. Local anesthesia infiltration is applied to all port sites.",[51],{"label":57,"type":58,"description":59,"interventionNames":60},"Left Lower Quadrant Extraction - No Local Anesthesia","ACTIVE_COMPARATOR","Specimen is extracted from the left lower quadrant port. No local anesthesia is infiltrated to the port sites",[61],"Other: Port-Site Saline Infiltration (Placebo)",{"label":63,"type":58,"description":64,"interventionNames":65},"Periumbilical Extraction - No Local Anesthesia","Specimen is extracted from the periumblical port. No local anesthesia is infiltrated to the port sites",[61],[67,72],{"type":68,"name":69,"description":70,"armGroupLabels":71,"otherNames":34},"DRUG","Port-site local anesthesia infiltration","Infiltration of local anesthetic solution (bupivacaine) into the skin, subcutaneous tissue, and fascial layers of all trocar sites prior to closure",[47,53],{"type":6,"name":73,"description":74,"armGroupLabels":75,"otherNames":34},"Port-Site Saline Infiltration (Placebo)","Prior to wound closure, a total of 10 cc of %0.9 normal saline solution is infiltrated into the skin, subcutaneous tissues, and fascial layers of all trocar sites as a placebo control",[57,63],[77],{"facility":78,"status":79,"city":80,"state":81,"zip":82,"country":83,"countryCode":34,"cosmosGeoPoint":84,"geoPoint":89,"contacts":90},"Gazi Yasargil Training and Research Hospital","RECRUITING","Diyarbakır","Kayapınar","21070","Turkey (Türkiye)",{"type":85,"coordinates":86},"Point",[87,88],40.21721,37.91363,{"lat":88,"lon":87},[91],{"name":92,"role":93,"phone":94,"phoneExt":34,"email":95},"Yunus YUKSEL","CONTACT","+905334367335","yunusyuksel35@gmail.com",{"type":97,"investigatorFullName":98,"investigatorTitle":99,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"SPONSOR_INVESTIGATOR","YUNUS YÜKSEL","General Surgery Resident","100656440","effect-of-specimen-extraction-site-and-local-anesthesia-on-postoperative-pain-in-laparoscopic-appendectomy-100656440",false,"NCT07824908","Effect Of Specimen Extraction Site And Local Anesthesia On Postoperative Pain In Laparoscopic Appendectomy","Inclusion Criteria:\n\n* Patients aged 18 years or older\n* Diagnosed with acute appendicitis\n* Scheduled for emergency laparoscopic appendectomy\n* Informed consent obtained\n\nExclusion Criteria:\n\n* Conversion to open surgery\n* Known allergy to local anesthetics\n* Cognitive impairment or inability to understand the NRS scoring system\n* Pregnancy","ALL","18 Years",{"count":109,"type":110},300,"ESTIMATED","INTERVENTIONAL",[113],"NA","The aim of this prospective, randomized study is to evaluate the effects of two different specimen extraction sites (periumbilical versus left lower quadrant) and the routine application of port-site local anesthesia infiltration on postoperative pain and complications in patients undergoing laparoscopic appendectomy for acute appendicitis.\"",[116,117,118],"Appendectomy, Laparoscopic","Appendicitis Acute","Pain Management",[120,121,122,123],"appendicitis acute","appendectomy laparoscopic","pain management","extraction site","2026-09-11",{"date":126,"type":127},"2026-09-17","ACTUAL",{"date":129,"type":127},"2026-04-24",{"date":131,"type":110},"2026-12-15",{"name":98,"class":6},1]