[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647376":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":43,"centralContacts":48,"locations":56,"responsibleParty":68,"collaborators":37,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":37,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":37,"maxAge":37,"enrollmentInfo":81,"targetDuration":37,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":98,"whyStopped":37,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,15,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Theravex Group","EXPERIMENTAL","Patients in this group will receive immediate implant placement where the jumping gap will be filled solely using Bone Bioactive Liquid (Theravex) to evaluate its effect on early osseointegration.",[13,14],"Device: Bone Bioactive Liquid","Procedure: Immediate Implant Placement",{"label":16,"type":17,"description":18,"interventionNames":19},"Xenograft Group","ACTIVE_COMPARATOR","Patients in this group will receive immediate implant placement where the jumping gap will be grafted using a standard bovine-derived xenograft bone mineral.",[20,14],"Device: Bovine-derived Xenograft",{"label":22,"type":10,"description":23,"interventionNames":24},"Combination Therapy Group","Patients in this group will receive immediate implant placement where the jumping gap will be grafted using a combination of the bovine-derived xenograft hydrated with the Bone Bioactive Liquid (Theravex).",[13,20,14],[26,33,38],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","Bone Bioactive Liquid","A bone bioactive liquid (Theravex) applied directly into the jumping gap and on implant surface immediately following implant placement to stimulate early bone healing and osseointegration.",[22,9],[32],"Theravex",{"type":27,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Bovine-derived Xenograft","Bovine derived- xenograft will be packed into the jumping gap to maintain volume and provide an osteoconductive scaffold for bone formation.",[22,16],null,{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":37},"PROCEDURE","Immediate Implant Placement","Surgical placement of the dental implant into the fresh extraction socket immediately following tooth extraction, according to standard surgical protocols.",[22,9,16],[44],{"name":45,"affiliation":46,"role":47},"Hadir F Eldessouky","Faculty of Dentistry - Ain Shams University","STUDY_DIRECTOR",[49,54],{"name":50,"role":51,"phone":52,"phoneExt":37,"email":53},"Abdallah A Aref, M.D.S","CONTACT","00201111711467","abdallah.aref.std@dent.asu.edu.eg",{"name":55,"role":51,"phone":37,"phoneExt":37,"email":37},"Susan M Sarhan",[57],{"facility":46,"status":37,"city":58,"state":37,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":37},"Cairo","11566","Egypt","EG",{"type":63,"coordinates":64},"Point",[65,66],31.24967,30.06263,{"lat":66,"lon":65},{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"PRINCIPAL_INVESTIGATOR","Abdallah Abdelnabi","Assistant Lecturer of Periodontology","100647376","effect-of-theravex-tissue-care-on-implant-stability-100647376",false,"NCT07707388","Effect of Theravex Tissue Care on Implant Stability","Effect of Theravex Tissue Care on Implant Stability in Immediate Implant Placement: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patient requires extraction of a single failing or non-restorable maxillary anterior tooth or premolar.\n* Presence of an intact buccal bone plate (Socket Type I) with a horizontal peri-implant jumping gap ≥ 2 mm.\n* The implant can be placed in an ideal 3-D position with an intraoperative primary stability target of ≥ 35 Ncm.\n* Patient is in good general health with no systemic contraindications to implant surgery.\n* Patient is cooperative and available for the entire 6-month follow-up period\n\nExclusion Criteria:\n\n* Pregnant and lactating females.\n* Heavy smokers (smoking ≥ 10 cigarettes per day).\n* Patients with poor oral hygiene.\n* Patients with occlusal or malalignment problems.\n* Patients with parafunctional habits (e.g., bruxism).",true,"ALL",{"count":82,"type":83},30,"ESTIMATED","INTERVENTIONAL",[86],"NA","The aim of this randomized clinical trial is to evaluate the clinical and radiographic outcomes of using Bone Bioactive Liquid (Theravex) compared to Xenograft and a combination therapy (Theravex + Xenograft) during immediate implant placement in the esthetic zone.\n\nWhen a tooth is extracted and replaced immediately with a dental implant, bone grafting is often necessary to fill the gap (jumping distance) between the implant and the surrounding bone socket to support tissue healing and maintain facial contour.\n\nParticipants requiring immediate implant placement will be randomly assigned into three groups:\n\nGroup 1: Immediate implant placement using Bone Bioactive Liquid (Theravex).\n\nGroup 2: Immediate implant placement using Xenograft alone.\n\nGroup 3: Immediate implant placement using Combination Therapy (Theravex + Xenograft).\n\nThe primary outcomes will evaluate implant stability, bone dimensional changes, and soft tissue response around the implants over the follow-up period.",[89],"Immediate Dental Implant Placement",[91,92,93,94,95,96,97],"immediate","implant","gap","jumping","socket","theravex","xenograft","NOT_YET_RECRUITING","2026-07-14",{"date":101,"type":102},"2026-07-16","ACTUAL",{"date":104,"type":83},"2026-11-12",{"date":106,"type":83},"2027-09-08",{"name":5,"class":6},1]