[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648066":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":36,"centralContacts":43,"locations":26,"responsibleParty":52,"collaborators":26,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":26,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":26,"overallStatus":76,"whyStopped":26,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":26},{"fullName":5,"class":6},"Cairo University","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Mulligan Thoracic Mobilization","EXPERIMENTAL","will receive Mulligan thoracic mobilization in extension five times per week for 8 weeks in addition to a standardized diet and aerobic exercise.",[13,14,15],"Procedure: Mulligan Thoracic Mobilization","Behavioral: low carbohydrate","Behavioral: Aerobic Exercise",{"label":17,"type":18,"description":19,"interventionNames":20},"low carbohydrate and Aerobic Exercises","ACTIVE_COMPARATOR","will receive standardized diet and aerobic exercise.",[14,15],[22,27,32],{"type":23,"name":9,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","* Technique: Thoracic mobilization with movement (MWM) in extension performed by a trained physiotherapist.\n* Performed 5×\u002Fweek.\n* Total program duration: 8 weeks.\n* 3 sets × 10 repetitions per spinal level per session.\n* Hold time: thoracic extension maintained for approximately 6 seconds at the end of the movement.\n* Participant position: sitting at the edge of the treatment table with hands behind the neck.\n* Therapist technique: mobilizing force applied using the ulnar border of the hand over the spinous process in a cephalic-anterior direction.\n* Movement performed: deep inspiration combined with thoracic extension during the mobilization.\n* Target levels: Mid-thoracic region (T6-T8).\n* Session duration: The session duration was based on three sets of ten repetitions per spinal level, with each repetition held for approximately 6 seconds. A 30-second rest interval was provided between sets, resulting in an effective application time of about 4-5 minutes per level.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"BEHAVIORAL","low carbohydrate","Standardized low-carbohydrate dietary program administered for 8 weeks.",[9,17],{"type":28,"name":33,"description":34,"armGroupLabels":35,"otherNames":26},"Aerobic Exercise","Moderate-intensity aerobic exercise program for 8 weeks, 5 sessions per week, at 55-69% HRmax or Borg RPE 12-14, progressing from 30 to 45 minutes per session.",[9,17],[37,40],{"name":38,"affiliation":5,"role":39},"Mona A Abdelwahab, Assistant Prof","STUDY_CHAIR",{"name":41,"affiliation":5,"role":42},"Shaimaa T Mohamed, Lecturer","STUDY_DIRECTOR",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":26,"email":48},"Abd El-Rahman A Abd El-Monem","CONTACT","00201124079292","abdelrahmanayman199810@gmail.com",{"name":50,"role":46,"phone":51,"phoneExt":26,"email":26},"Alaa N Abdelhameed","00201061382864",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Abd El-Rahman Ayman Mohamed Abd El-Monem","Teaching Assistant","100648066","effect-of-thoracic-mobilization-in-people-with-central-obesity-100648066",false,"NCT07718178","Effect of Thoracic Mobilization in People With Central Obesity","Effect of Mulligan Thoracic Mobilization on Ventilatory Functions and Chest Wall Expansion in Central Obesity","Inclusion Criteria:\n\n* Males aged 25-35 years.\n* Presence of central obesity, defined as:\n\n  * Waist circumference ≥102 cm in males.\n  * Waist-hip ratio (WHR) ≥0.90 in males.\n* BMI from 30-39.9 kg\u002Fm².\n* Willing to comply with conventional physiotherapy (diet and exercise) and mobilization programs.\n* Medically stable individuals with a restrictive lung pattern (Normal FEV₁\u002FFVC ratio and FVC \\\u003C 80% of predicted).\n* Low level physical activity (using the International Physical Activity Questionnaire-Short Version).\n* Non-smokers.\n\nExclusion Criteria:\n\n* Diagnosed COPD, asthma, or other chronic respiratory diseases.\n* Recent thoracic spine or rib injury\u002Fsurgery.\n* Cardiovascular instability or uncontrolled hypertension.\n* Contraindications to manual therapy (e.g., osteoporosis, rib fractures, or spinal tumors).\n* Participation in any structured weight loss program or exercise regimen in the past 6 months.\n* History of bariatric surgery (e.g., gastric sleeve, gastric bypass).\n* Use of medications that affect body weight or metabolism (e.g., corticosteroids, antipsychotics, weight loss drugs).\n* Neurological or musculoskeletal conditions that limit mobility or exercise participation and interfere with gait.\n* Any acute respiratory infections in the past 6 weeks.","MALE","25 Years","35 Years",{"count":67,"type":68},60,"ESTIMATED","INTERVENTIONAL",[71],"NA","The goal of this clinical trial is to learn whether Mulligan thoracic mobilization in extension improves ventilatory functions and chest wall expansion in adults with central obesity. It will also evaluate whether adding Mulligan thoracic mobilization to a low-carbohydrate diet and aerobic exercise provides greater benefits than diet and exercise alone.\n\nThe main questions it aims to answer are:\n\nDoes Mulligan thoracic mobilization improve ventilatory functions (FVC, FEV₁, FEV₁\u002FFVC ratio, and MVV) in adults with central obesity? Does Mulligan thoracic mobilization improve chest wall expansion, functional capacity, and health-related quality of life?\n\nResearchers will compare Mulligan thoracic mobilization combined with a low-carbohydrate diet and aerobic exercise to a low-carbohydrate diet and aerobic exercise alone to determine whether the addition of thoracic mobilization improves respiratory outcomes.\n\nParticipants will:\n\nBe randomly assigned to either the intervention group or the control group. Receive an individualized low-carbohydrate diet and supervised aerobic exercise for 8 weeks.\n\nReceive Mulligan thoracic mobilization in extension five times per week for 8 weeks if assigned to the intervention group.\n\nUndergo assessments of ventilatory functions, chest wall expansion, functional capacity, and quality of life before and after the intervention.",[74,75],"Central Obesity","Ventilatory Function","NOT_YET_RECRUITING","2026-07-28",{"date":79,"type":80},"2026-07-29","ACTUAL",{"date":82,"type":68},"2026-07-25",{"date":84,"type":68},"2027-02-10",{"name":5,"class":6}]