[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646297":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":17,"locations":7,"responsibleParty":28,"collaborators":7,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":37,"acronym":7,"eligibilityCriteria":38,"healthyVolunteers":34,"sex":39,"minAge":40,"maxAge":41,"enrollmentInfo":42,"targetDuration":7,"studyType":45,"phases":7,"briefSummary":46,"conditions":47,"keywords":7,"overallStatus":50,"whyStopped":7,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":7},{"fullName":5,"class":6},"First Affiliated Hospital of Chongqing Medical University","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"PROCEDURE","VExUS Score-Guided Intraoperative Goal-Directed Fluid Therapy","Intervention Group: VExUS score will be performed by an ultrasonographer proficient in ultrasound operation (with \\> 100 cases of experience and special certification from the Ultrasound Physician Branch of the Chinese Medical Doctor Association) at the following time points: preoperatively, after thoracic procedure, after abdominal procedure, and at the end of surgery.",[14],{"name":15,"affiliation":7,"role":16},"Juying Jin","STUDY_DIRECTOR",[18,24],{"name":19,"role":20,"phone":21,"phoneExt":22,"email":23},"Lihua Li Peng, Doctor","CONTACT","+86 89011876","+8615823443968","plhcqmu@163.com",{"name":25,"role":20,"phone":21,"phoneExt":26,"email":27},"Mengninng Wan, Doctor","+8615215151223","1029211312@qq.com",{"type":29,"investigatorFullName":30,"investigatorTitle":31,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Mengning Wan","Principal Investigator","100646297","effect-of-vexus-score-on-postoperative-pulmonary-complications-in-elderly-patients-100646297",false,"NCT07691944","Effect of VExUS Score on Postoperative Pulmonary Complications in Elderly Patients","Effect of VExUS Score-Guided Intraoperative Goal-Directed Fluid Therapy on Postoperative Pulmonary Complications in Elderly Patients Undergoing McKeown Minimally Invasive Esophagectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 65 and 80 years old\n* Scheduled for elective McKeown MIE\n* ASA physical status classification I to III\n* Body mass index (BMI) between 18 kg\u002Fm² and 30 kg\u002Fm² (exclusive of 18 kg\u002Fm²)\n\nExclusion Criteria:\n\n* Respiratory failure (SaO₂ \\\u003C 60 mmHg and\u002For PaCO₂ \\> 50 mmHg)\n* Severe cardiac dysfunction (NYHA class III-IV)\n* Angina pectoris within the past 3 months or acute myocardial infarction (STEMI\u002FNSTEMI) within the past 6 months\n* Pulmonary hypertension (pulmonary artery systolic pressure, PASP \\> 35 mmHg)\n* Moderate to severe tricuspid stenosis\u002Fregurgitation (valve orifice area \\\u003C 1.5 cm² \u002F vena contracta width ≥ 0.3 cm)\n* Decompensated cirrhosis (Child-Pugh class ≥ B)\n* Chronic kidney disease (CKD stage ≥ 3a) (estimated glomerular filtration rate, eGFR \\\u003C 45 mL\u002Fmin\u002F1.73 m²)\n* Cognitive impairment (Mini-Mental State Examination, MMSE \\\u003C 27) and inability to cooperate with follow-up","ALL","65 Years","80 Years",{"count":43,"type":44},126,"ESTIMATED","OBSERVATIONAL","Brief Summary This clinical trial aims to evaluate whether perioperative goal-directed fluid therapy (GDFT) targeting a venous excess ultrasound (VExUS) score of 1 can reduce postoperative pulmonary complications (PPCs) in elderly patients undergoing McKeown minimally invasive esophagectomy (MIE). The study will also assess postoperative organ microcirculatory perfusion and quality of recovery.\n\nKey research questions the trial seeks to answer include:\n\nDoes VExUS score-guided GDFT reduce the incidence of PPCs in elderly patients following McKeown MIE? Do participants receiving VExUS-guided GDFT achieve better clinical outcomes? Investigators will compare VExUS score-targeted GDFT with fluid therapy guided by the standard Vigileo-FloTrac™ system, to determine if the VExUS-guided approach reduces the occurrence of postoperative pulmonary complications in elderly patients.\n\nParticipant assessments and data collection include:\n\nVExUS score assessment at four time points: preoperatively, after thoracic phase of surgery, after abdominal phase of surgery, and at the end of surgery. Concomitant measurements will include capillary refill time (CRT, in minutes), perfusion index (PI), blood lactate level (Lac, in mmol\u002FL), and central venous oxygen saturation (ScvO₂, in percent).\n\nPostoperative lung ultrasound score assessment. Recording of clinical outcomes including length of intensive care unit (ICU) stay (in days), postoperative hospital length of stay (in days), 30-day postoperative readmission rate due to pulmonary complications (in percent), and in-hospital postoperative mortality rate (in percent).",[48,49],"Esophageal Cancer (EsC)","Postoperative Pulmonary Complications (PPCs)","NOT_YET_RECRUITING","2026-07-07",{"date":53,"type":54},"2026-07-09","ACTUAL",{"date":56,"type":44},"2026-08-01",{"date":58,"type":44},"2026-12-31",{"name":5,"class":6}]