[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627693":3},{"organization":4,"outcomesModule":7,"designInfo":28,"detailedDescription":27,"studyPopulation":27,"armGroups":35,"interventions":48,"overallOfficials":27,"centralContacts":27,"locations":56,"responsibleParty":86,"collaborators":90,"id":95,"slug":96,"hasResults":97,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":27,"eligibilityCriteria":101,"healthyVolunteers":102,"sex":103,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":27,"studyType":109,"phases":110,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":59,"whyStopped":27,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":129},{"fullName":5,"class":6},"Aga Khan University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":27},[9],{"measure":10,"description":11,"timeFrame":12},"Stunting","length-for-age z-score (LAZ) \\\u003C -2 SD","Monthly from enrollment to the end of intervention period at 6 months",[14,17,20,23],{"measure":15,"description":16,"timeFrame":12},"Wasting","weight-for-length z-score (WLZ) \\\u003C -2 SD",{"measure":18,"description":19,"timeFrame":12},"Underweight","weight-for-age z-score (WAZ) \\\u003C -2 SD",{"measure":21,"description":22,"timeFrame":12},"Morbidity","Includes diarrhea (liquid stools defined as ≥3 loose or watery stools within 24 hour), respiratory infection (cough plus rapid, difficult breathing), vomiting, fever, rash\u002Fsores, coughing, wheezing and pneumonia.",{"measure":24,"description":25,"timeFrame":26},"Prevalence of anemia","hemoglobin \\\u003C10.5 g\u002FdL.\n\nFor mild anemia: hemoglobin 9.5 - 10.4 g\u002FdL For moderate anemia: 7.0 - 9.4 g\u002FdL For severe anemia: \\\u003C7.0 g\u002FdL","At enrollment and later at the end of intervention period at 6 months",null,{"allocation":29,"interventionModel":30,"interventionModelDescription":27,"primaryPurpose":31,"observationalModel":27,"timePerspective":27,"maskingInfo":32},"RANDOMIZED","PARALLEL","PREVENTION",{"masking":33,"maskingDescription":34,"whoMasked":27},"NONE","The statistical analysis team will remain blinded to the intervention allocation to minimize the risk of bias.",[36,42],{"label":37,"type":38,"description":39,"interventionNames":40},"Medium-quantity lipid-based nutrient supplement (MQ-LNS)","ACTIVE_COMPARATOR","Children receiving MQ-LNS",[41],"Dietary Supplement: Medium-quantity lipid-based nutrient supplement (MQ-LNS)",{"label":43,"type":44,"description":45,"interventionNames":46},"Small-quantity lipid-based nutrient supplement (SQ-LNS)","EXPERIMENTAL","Children receiving SQ-LNS",[47],"Dietary Supplement: Small-quantity lipid-based nutrient supplement (SQ-LNS)",[49,53],{"type":50,"name":37,"description":51,"armGroupLabels":52,"otherNames":27},"DIETARY_SUPPLEMENT","50 g\u002Fday lipid-based nutrient supplement providing energy and essential micronutrients, administered daily for 6 months.",[37],{"type":50,"name":43,"description":54,"armGroupLabels":55,"otherNames":27},"20 g\u002Fday lipid-based nutrient supplement providing energy and essential micronutrients, administered daily for 6 months.",[43],[57,76],{"facility":58,"status":59,"city":60,"state":61,"zip":27,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"BNP Facilitation Centers","RECRUITING","Peshawar","Khyber Pakhtunkhwa","Pakistan","PK",{"type":65,"coordinates":66},"Point",[67,68],71.57849,34.008,{"lat":68,"lon":67},[71],{"name":72,"role":73,"phone":74,"phoneExt":27,"email":75},"Dr Sajid Soofi","CONTACT","+922134864798","sajid.soofi@aku.edu",{"facility":58,"status":59,"city":77,"state":78,"zip":27,"country":62,"countryCode":63,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Dadu","Sindh",{"type":65,"coordinates":80},[81,82],67.7769,26.73033,{"lat":82,"lon":81},[85],{"name":72,"role":73,"phone":74,"phoneExt":27,"email":75},{"type":87,"investigatorFullName":88,"investigatorTitle":89,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Dr Shabina Ariff","Professor Shabina Ariff",[91,93],{"name":92,"class":6},"United Nations World Food Programme (WFP)",{"name":94,"class":6},"Benazir Income Support Programme (BISP)","100627693","effectiveness-of-small-quantity-vs-medium-quantity-lipid-based-nutrient-supplements-for-prevention-of-undernutrition-in-children-6-12-months-100627693",false,"NCT07451951","Effectiveness of Small-Quantity vs Medium-Quantity Lipid-Based Nutrient Supplements for Prevention of Undernutrition in Young Children","Effectiveness of Small-Quantity vs Medium-Quantity Lipid-Based Nutrient Supplements for Prevention of Undernutrition in Young Children: An Individually Randomized, Parallel-Group, Non-Inferiority Trial","Inclusion Criteria:\n\n* Children aged 6 months (26 weeks) to 7 months and 15 days (33 weeks) with weight-for-length z-score (WLZ) ≥ -2 standard deviation (SD) and mid-upper arm circumference (MUAC) ≥125 mm, born to mothers who are beneficiaries of the Benazir Income Support Programme and registered with the Benazir Nashonuma Programme (BNP) at any point during their pregnancy.\n* Permanent residents of the selected districts, with no plan to relocate or migrate within the next 6 months.\n* Written informed consent provided by the child's caregivers.\n\nExclusion Criteria:\n\n* Children with moderate acute malnutrition (MAM), defined as WLZ ≥ -3 to \\\u003C -2 SD, or MUAC ≥115 mm to \\\u003C125 mm.\n* Children with severe acute malnutrition (SAM), defined as WLZ \\\u003C -3 SD or MUAC \\\u003C115 mm or presence of bilateral pitting edema, who require therapeutic feeding.\n* Children with known congenital anomalies, chronic illness, or conditions affecting growth or feeding (for example, cerebral palsy or congenital heart disease).\n* Children already enrolled in any nutritional supplementation other than BNP or another clinical trial.\n* Children whose families will be unwilling to provide informed consent, or likely to be unavailable for follow-up.",true,"ALL","26 Weeks","33 Weeks",{"count":107,"type":108},1568,"ESTIMATED","INTERVENTIONAL",[111],"NA","Nutrition is essential for a child's growth, brain development, and protection from disease. While breastmilk provides the best nutrition for young infants, children older than six months may not get all the nutrients they need from breastmilk and regular foods alone. For this reason, some children receive special nutrient supplements to support healthy growth.\n\nLipid-based nutrient supplements (LNS) are one type of supplement that provides important vitamins and minerals. These supplements are used in many countries to help prevent undernutrition in young children. In Pakistan, the government-led multisectoral nutrition program under the social safety net program currently provides medium-quantity LNS to children starting at six months of age. However, it is not known whether a smaller-quantity LNS could provide similar benefits for children in this age group from under-resourced communities that have limited access to nutritious foods.\n\nThe goal of this trial is to learn whether small-quantity lipid-based nutrient supplements (SQ-LNS) work as well as medium-quantity lipid-based nutrient supplements (MQ-LNS) in preventing undernutrition in children aged 6 to 12 months.\n\nThe main questions this study aims to answer are:\n\n* Does SQ-LNS work as well as MQ-LNS in supporting healthy growth, including reducing stunting, wasting, and underweight?\n* Does SQ-LNS work as well as MQ-LNS in reducing anemia?\n\nResearchers will compare SQ-LNS and MQ-LNS to see if SQ-LNS is as good as MQ-LNS in preventing undernutrition.\n\nThe study is being conducted in Dadu and Peshawar, Pakistan. Participants will be followed until 12 months of age.\n\nParticipants will:\n\n* Receive either SQ-LNS or MQ-LNS once daily until 12 months of age\n* Have their length, weight and mid-upper arm circumference (MUAC) measured monthly\n* Have their blood screened for anemia at enrollment and at 12 months of age",[114],"Undernutrition",[10,15,116,18,117,118,119],"Anemia","Small-quantity lipid-based nutrient supplement","Child nutrition","Medium-quantity lipid-based nutrient supplement","2026-09-01",{"date":122,"type":123},"2026-09-03","ACTUAL",{"date":125,"type":123},"2026-02-26",{"date":127,"type":108},"2028-12-31",{"name":5,"class":6},2]