[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649086":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":39,"centralContacts":44,"locations":31,"responsibleParty":49,"collaborators":31,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":31,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":31,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":31,"overallStatus":73,"whyStopped":31,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":31},{"fullName":5,"class":6},"Pakistan Institute of Medical Sciences","OTHER_GOV",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Conventional Needle Irrigation","ACTIVE_COMPARATOR","Participants in this group will receive root canal irrigation using a conventional 27-gauge syringe needle. The irrigant, consisting of a radiopaque iohexol dye mixed with 5.25% sodium hypochlorite, will be delivered into the prepared root canal using the conventional needle irrigation technique. Irrigant penetration into the apical third will be assessed using digital radiographs.",[13],"Procedure: Conventional Needle",{"label":15,"type":10,"description":16,"interventionNames":17},"Side Vented Needle Irrigation","Participants in this group will receive root canal irrigation using a side-vented irrigation needle. The radiopaque irrigant solution, prepared by mixing iohexol dye with 5.25% sodium hypochlorite, will be delivered into the canal using the side-vented needle technique. Irrigant penetration into the apical third will be measured on digital radiographs.",[18],"Procedure: Side Vented Needle",{"label":20,"type":21,"description":22,"interventionNames":23},"Ultrasonic Irrigation","EXPERIMENTAL","Participants in this group will receive ultrasonic irrigation following completion of canal preparation. A radiopaque irrigant solution consisting of iohexol dye mixed with 5.25% sodium hypochlorite will be ultrasonically activated within the root canal. Digital radiographs will be used to measure the depth of irrigant penetration into the apical third and compare it with the other irrigation techniques",[24],"Procedure: Ultrasonic Irrigation",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","Conventional Needle","Conventional syringe irrigation will be performed using a 27-gauge needle to deliver the radiopaque sodium hypochlorite solution into the prepared root canal. No additional activation technique will be used during irrigation",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Side Vented Needle","Irrigation will be carried out using a side-vented needle to introduce the radiopaque sodium hypochlorite solution into the prepared canal. The side-vented design is intended to improve irrigant distribution within the canal while minimizing direct apical flow",[15],{"type":27,"name":20,"description":37,"armGroupLabels":38,"otherNames":31},"Following canal preparation, the radiopaque sodium hypochlorite solution will be activated using an ultrasonic device to enhance irrigant movement throughout the root canal system before radiographic evaluation of penetration depth.",[20],[40],{"name":41,"affiliation":42,"role":43},"Haroon H Panezai, BDS","School Of Dentistry, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad","PRINCIPAL_INVESTIGATOR",[45],{"name":41,"role":46,"phone":47,"phoneExt":31,"email":48},"CONTACT","+923128708722","haroonhpanezai@gmail.com",{"type":43,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Haroon Hafeez","Principal Investigator","100649086","effectiveness-of-three-different-irrigation-methods-during-a-root-canal-treatment-100649086",false,"NCT07731594","Effectiveness of Three Different Irrigation Methods During a Root Canal Treatment","Effect of Various Irrigant Activation Methods and Its Penetration in the Apical Third of Root Canal","Inclusion Criteria:\n\n* Straight Canals\n* Single Rooted 1st and 2nd mandibular premolars with closed apices\n\nExclusion Criteria:\n\n* Mandibular premolars with open apices\n* Mandibular premolars with curved or calcified canals",true,"ALL","20 Years","50 Years",{"count":64,"type":65},105,"ESTIMATED","INTERVENTIONAL",[68],"NA","This study aims to compare the effectiveness of three root canal irrigation techniques-Conventional Needle Irrigation (CNI), Side-Vented Needle (SVN), and Ultrasonic Irrigation (UI)-in achieving irrigant penetration into the apical third of the root canal. Since conventional irrigation often fails to adequately clean complex root canal anatomy, the study evaluates whether activation methods improve irrigant penetration. A randomized controlled trial will compare these three techniques using extracted single-rooted mandibular premolars. A radiopaque dye mixed with sodium hypochlorite will be used to measure irrigant penetration on digital radiographs, and the results will be statistically analyzed to determine the most effective irrigation method.",[71,72],"Three Canal Irrigation Methods and Their Comparison","Penetration of Irrigant in the Root Canal","NOT_YET_RECRUITING","2026-07-25",{"date":76,"type":77},"2026-07-28","ACTUAL",{"date":79,"type":65},"2026-07-12",{"date":81,"type":65},"2026-12-26",{"name":5,"class":6}]