[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650098":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":28,"locations":34,"responsibleParty":73,"collaborators":75,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":11,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":11,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":11,"overallStatus":98,"whyStopped":11,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"The Hong Kong Polytechnic University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Chatbot","EXPERIMENTAL",null,[13],"Other: Chatbot",{"label":15,"type":16,"description":11,"interventionNames":17},"Electronic brochure","ACTIVE_COMPARATOR",[18],"Other: Electronic brochure",[20,25],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"A large language model-driven chatbot that incorporates acceptance and commitment therapy, a verified onco-fertility knowledge base, and relevant policy information.",[9],[24],"FLORA",{"type":6,"name":15,"description":26,"armGroupLabels":27,"otherNames":11},"An electronic brochure that contains psychoeducational materials, verified onco-fertility knowledge, and relevant policy information.",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},"Xinyu Feng","CONTACT","852 56144565","xinyu211.feng@connect.polyu.hk",[35,57],{"facility":36,"status":11,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"The University of Science and Technology of China","Hefei","Anhui","230026","China","CN",{"type":43,"coordinates":44},"Point",[45,46],117.28083,31.86389,{"lat":46,"lon":45},[49,53,55],{"name":50,"role":31,"phone":51,"phoneExt":11,"email":52},"Lingyun Tian","86 18225853895","464200541@qq.com",{"name":30,"role":54,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"name":50,"role":56,"phone":11,"phoneExt":11,"email":11},"SUB_INVESTIGATOR",{"facility":5,"status":11,"city":58,"state":11,"zip":11,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Kowloon","Hong Kong","HK",{"type":43,"coordinates":62},[63,64],114.18333,22.31667,{"lat":64,"lon":63},[67,71,72],{"name":68,"role":31,"phone":69,"phoneExt":11,"email":70},"Vivian Hui","852 27664691","vivianc.hui@polyu.edu.hk",{"name":68,"role":54,"phone":11,"phoneExt":11,"email":11},{"name":30,"role":56,"phone":11,"phoneExt":11,"email":11},{"type":74,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[76],{"name":36,"class":6},"100650098","effects-of-a-large-language-model-driven-chatbot-on-reproductive-concerns-after-cancer-100650098",false,"NCT07741266","Effects of a Large Language Model-Driven Chatbot on Reproductive Concerns After Cancer","The Feasibility and Preliminary Effectiveness of a Large Language Model-Driven Chatbot in Addressing Reproductive Concerns Among Adolescent and Young Adult Cancer Survivors: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n(1) 15-39-year-old females; (2) cancer diagnosis between ages 15-39; (3) current or prior concerns regarding fertility; (4) proficiency in Mandarin Chinese; and (5) access to a mobile device for intervention delivery.\n\nExclusion Criteria:\n\n(1) Involvement in the chatbot co-design phases; (2) inability to provide informed consent; (3) significant sensory, cognitive, or psychological impairments precluding meaningful participation; and (4) acute illness at the time of recruitment.","FEMALE","15 Years","39 Years",{"count":88,"type":89},60,"ESTIMATED","INTERVENTIONAL",[92],"NA","Reproductive health has emerged as a critical yet overlooked concern among Adolescent and Young Adult (AYA) cancer survivors, given their compromised potential for biological parenthood in prime childbearing years. Large language models (LLMs) offer a promising solution to bridge onco-fertility service gaps by integrating evidence-based knowledge and therapeutic frameworks. This pilot randomized controlled trial aims to assess the feasibility and preliminary effectiveness of an LLM-driven chatbot versus electronic brochure in addressing reproductive concerns among AYA cancer survivors.",[9,95,96,97],"Large Language Model","Adolescent and Young Adult Cancer Survivors","Reproductive Health","NOT_YET_RECRUITING","2026-07-28",{"date":101,"type":102},"2026-08-03","ACTUAL",{"date":104,"type":89},"2026-09-01",{"date":106,"type":89},"2027-06-30",{"name":5,"class":6},2]