[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659806":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":13,"armGroups":22,"interventions":33,"overallOfficials":13,"centralContacts":13,"locations":13,"responsibleParty":42,"collaborators":13,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":13,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":13,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":70,"whyStopped":13,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":13},{"fullName":5,"class":6},"University of Lahore","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Quadriceps Muscle Strength","Quadriceps muscle strength will be assessed using an isokinetic dynamometer or handheld dynamometer following ACL reconstruction.","Baseline, 4 weeks, and 8 weeks",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":19,"maskingDescription":13,"whoMasked":20},"SINGLE",[21],"OUTCOMES_ASSESSOR",[23,29],{"label":24,"type":25,"description":13,"interventionNames":26},"Standard Physical Therapy","ACTIVE_COMPARATOR",[27,28],"Device: Anodal Transcranial Direct Current Stimulation (tDCS)","Other: Standard Physical Therapy",{"label":30,"type":31,"description":13,"interventionNames":32},"Standard Physical Therapy Plus Anodal tDCS","EXPERIMENTAL",[27,28],[34,39],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":13},"DEVICE","Anodal Transcranial Direct Current Stimulation (tDCS)","Anodal transcranial direct current stimulation (tDCS) will be administered using a CE\u002FFDA-approved constant-current tDCS device. Stimulation will be delivered at 2 mA for 20 minutes per session, 3 sessions per week, immediately before supervised physiotherapy, for 4 weeks (12 sessions). The anode will be placed over the contralateral primary motor cortex (M1) quadriceps representation (C3 for the right leg and C4 for the left leg), using the international 10-20 system, while the cathode will be positioned over the contralateral supraorbital region.",[24,30],{"type":6,"name":24,"description":40,"armGroupLabels":41,"otherNames":13},"Standard physical therapy for 8 weeks, 1 hour per day, 3 times per week, for a total of 24 sessions.",[24,30],{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Maryam Shabbir","Dr. Maryam Shabbir","100659806","effects-of-anodal-transcranial-direct-current-stimulation-on-muscle-inhibition-after-acl-reconstruction-100659806",false,"NCT07866963","Effects of Anodal Transcranial Direct Current Stimulation on Muscle Inhibition After ACL Reconstruction","Effects of Anodal Transcranial Direct Current Stimulation on Arthrogenic Muscle Inhibition in Athletes Following ACL Reconstruction","Inclusion Criteria:\n\n* Participants with unilateral primary ACL reconstruction. ACL reconstruction performed using hamstring autograft (semitendinosus ± gracilis).\n\nParticipants 0-4 weeks post-operative. Age 15-45 years. Participants receiving no other rehabilitation treatment. Participants who provide voluntary informed consent.\n\nExclusion Criteria:\n\n* Contraindications to rehabilitation, such as wounds or infections. Lower-extremity venous thrombosis. Serious cognitive impairment or inability to cooperate. Severe cardiac insufficiency, renal failure, or other diseases contraindicating exercise.\n\nCombined fractures\u002Fcartilage injuries or multiple ligament injuries. Severe osteoporosis. Bone tumor of the lower limb or history of spinal tuberculosis. Passive joint extension limitation due to joint or surgery. Metal implants near the head. History of seizures. Previous exposure to tDCS. Cognitive disorders.","ALL","15 Years","45 Years",{"count":57,"type":58},64,"ESTIMATED","INTERVENTIONAL",[61],"NA","This randomized controlled trial will investigate the effects of anodal transcranial direct current stimulation (tDCS) on arthrogenic muscle inhibition in athletes following anterior cruciate ligament (ACL) reconstruction. Participants will be allocated into two groups: a control group receiving standard physical therapy and an experimental group receiving standard physical therapy combined with anodal tDCS over the primary motor cortex (M1). The tDCS intervention will be delivered at 2 mA for 20 minutes, three times per week for four weeks, immediately before supervised physiotherapy. The study will assess quadriceps muscle strength, arthrogenic muscle inhibition, neuromuscular control, and subjective knee function at baseline, four weeks, and eight weeks. The study aims to determine whether adding anodal tDCS to standard rehabilitation improves outcomes following ACL reconstruction.",[64],"ACL Reconstruction",[66,67,68,69],"Anterior Cruciate Ligament Reconstruction;","Arthrogenic Muscle Inhibition;","Transcranial Direct Current Stimulation;","Anodal tDCS;","NOT_YET_RECRUITING","2026-10-04",{"date":73,"type":74},"2026-10-09","ACTUAL",{"date":76,"type":58},"2026-11",{"date":78,"type":58},"2027-02",{"name":5,"class":6}]