[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613031":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":53,"collaborators":25,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Istinye University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Blood Flow Restriction Aerobic Exercise Group","ACTIVE_COMPARATOR","Participants in this group will perform low-intensity aerobic exercise on a cycle ergometer under blood flow restriction (BFR) as part of pulmonary rehabilitation. BFR pressure will be applied bilaterally to the proximal thighs using pneumatic cuffs at 40-50% of each participant's limb occlusion pressure. Sessions will include warm-up, 15 minutes of aerobic exercise, and cool-down, supervised by a physiotherapist. No aerobic exercise without BFR will be performed in this arm.",[13],"Behavioral: Blood Flow Restriction Aerobic Exercise Training",{"label":15,"type":10,"description":16,"interventionNames":17},"Conventional Aerobic Exercise Group","Participants in this arm will perform standard aerobic exercise on a cycle ergometer as part of conventional pulmonary rehabilitation without blood flow restriction. Exercise intensity will be prescribed at 60-80% of the target heart rate calculated using the Karvonen formula. Each session will include a 3-minute warm-up, 15 minutes of continuous aerobic exercise, and a 3-minute cool-down. Exercise intensity, frequency, and duration will be matched to the BFR aerobic exercise group. All sessions will be supervised by an experienced physiotherapist. No blood flow restriction will be applied in this arm.",[18],"Behavioral: Conventional Aerobic Exercise Training",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Blood Flow Restriction Aerobic Exercise Training","Blood Flow Restriction Aerobic Exercise Training Participants will undergo aerobic exercise performed with blood flow restriction (BFR) applied to both thighs using pneumatic cuffs positioned at the proximal portion of the lower limbs. Cuff pressure will be individualized for each participant based on limb occlusion pressure (LOP), determined by Doppler assessment. During training, cuffs will be inflated to 40-50% of the participant's LOP and will remain inflated throughout the aerobic exercise phase. Sessions will include warm-up, continuous low-intensity cycling, and cool-down, supervised by a physiotherapist. The purpose of this intervention is to induce physiological adaptations associated with BFR, such as increased metabolic stress and muscular activation, while using low mechanical load.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Conventional Aerobic Exercise Training","Participants in this group will perform aerobic exercise on a cycle ergometer without blood flow restriction (BFR) as part of standard pulmonary rehabilitation. The aerobic exercise protocol will be performed at 60-80% of the participant's target heart rate (THR), calculated using the Karvonen formula:\n\nTHR = \\[(HRmax - HRrest) × % intensity\\] + HRrest.\n\nTraining will be performed twice per week for a total of 8 weeks and will include 3 minutes of warm-up, 15 minutes of target-intensity aerobic cycling, and 3 minutes of cool-down (total duration: 21 minutes). Pedal resistance and cadence will be adjusted according to the Borg Rating of Perceived Exertion (RPE), with the target RPE maintained between 3 and 4. Exercise intensity (watt level) will be progressed weekly by approximately 5-10%, aligned with tolerance and RPE scores (Patterson et al., 2019). No BFR will be applied at any stage of the intervention.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Fahrettin Özelçi","CONTACT","+90 531 886 5717","fahrettin.ozelci@stu.istinye.edu.tr",[37],{"facility":38,"status":39,"city":40,"state":25,"zip":41,"country":42,"countryCode":25,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Sultan Abdulhamid Han Training and Research Hospital","RECRUITING","Istanbul","34668","Turkey (Türkiye)",{"type":44,"coordinates":45},"Point",[46,47],28.94966,41.01384,{"lat":47,"lon":46},[50],{"name":51,"role":33,"phone":52,"phoneExt":25,"email":35},"FAHRETTİN ÖZELÇİ, MSc-PT","05318865717",{"type":54,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100613031","effects-of-blood-flow-restriction-aerobic-exercise-on-inflammation-hypoxia-exercise-capacity-and-lung-function-in-copd-100613031",false,"NCT07261293","Effects of Blood Flow Restriction Aerobic Exercise on Inflammation, Hypoxia, Exercise Capacity, and Lung Function in COPD","Effects of Blood Flow Restriction Aerobic Exercise on Systemic Inflammation, Hypoxia, Exercise Capacity, and Pulmonary Functions in Patients With Chronic Obstructive Pulmonary Disease: A Prospective Randomized Controlled Trial","BFR-COPD","Inclusion Criteria:\n\n* Individuals aged between 40 and 80 years\n* Clinically stable patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD) according to GOLD 2024 criteria with post-bronchodilator FEV₁\u002FFVC \\\u003C 0.70\n* Stable clinical condition (no acute exacerbation within the past 4 weeks)\n* Individuals clinically evaluated and approved as suitable for pulmonary rehabilitation (PR) participation by a cardiology specialist\n* Functional capacity sufficient to participate in PR (e.g., 6-Minute Walk Test ≥150 m)\n* No contraindications to blood flow restriction (BFR) training (e.g., no peripheral vascular disease, no active thrombosis)\n* Ability to understand and follow instructions (adequate auditory and cognitive function)\n\nExclusion Criteria:\n\n* Acute exacerbation of COPD, hospitalization, or systemic corticosteroid treatment within the past 4 weeks\n* Severe cardiovascular disease (uncontrolled hypertension \\>180\u002F110 mmHg, myocardial infarction within the past 6 months, unstable angina, congestive heart failure NYHA Class III-IV)\n* Neurological or orthopedic conditions significantly limiting lower-extremity function (e.g., hemiplegia, amputation, severe osteoarthritis, knee prosthesis)\n* Severe renal impairment (GFR \\\u003C30 mL\u002Fmin\u002F1.73 m²) or severe hepatic failure\n* History of lower-extremity surgery within the past 3 months\n* Active malignancy or systemic infection\n* Anemia or chronic inflammatory\u002Fautoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease)\n* History of venous thromboembolism\n* Peripheral arterial disease\n* Physician-diagnosed sarcopenia\n* Psychiatric disorders (major depression, dementia, psychotic disorders) limiting adherence to the study protocol","ALL","40 Years","80 Years",{"count":67,"type":68},34,"ESTIMATED","INTERVENTIONAL",[71],"NA","Purpose:\n\nThis study aims to compare the effects of the classical pulmonary rehabilitation (PR) program and blood flow restriction (BFR) applied during low-intensity aerobic exercise within PR on systemic inflammation, hypoxemia, exercise capacity, pulmonary function, respiratory muscle strength, and quality-of-life parameters in individuals with COPD.\n\nMethods:\n\nThis randomized controlled study will include 34 individuals with COPD, allocated into a BFR aerobic group and a control group. Both groups will receive core PR components, including diaphragmatic breathing, pursed-lip breathing, respiratory muscle training, and peripheral muscle strengthening. The BFR group will perform low-intensity aerobic exercise with blood flow restriction, while the control group will perform moderate-intensity aerobic exercise without BFR in accordance with standard PR protocols. All sessions will be supervised by a physiotherapist, twice per week, for eight weeks. Systemic inflammation markers, arterial blood gases, pulmonary function, exercise capacity, quality of life, and symptom scores will be assessed before PR, after the 8th session, and at the end of the program. Data will be analyzed using SPSS 26.0.\n\nExpected Contribution:\n\nThis study aims to provide evidence-based insights into the physiological and clinical effects of low-intensity BFR aerobic exercise within PR and to determine its potential advantages compared with classical PR. Additionally, it seeks to clarify whether low-intensity BFR aerobic exercise may serve as a better-tolerated alternative for COPD patients who experience exercise intolerance during moderate-intensity aerobic training.",[74],"COPD (Chronic Obstructive Pulmonary Disease)",[76,77,78,79],"COPD","BFR","Aerobic exercise","Exercise capacity","2026-08-13",{"date":82,"type":83},"2026-08-17","ACTUAL",{"date":85,"type":83},"2025-12-01",{"date":87,"type":68},"2026-12-15",{"name":5,"class":6},1]