[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590979":3},{"organization":4,"outcomesModule":7,"designInfo":47,"detailedDescription":46,"studyPopulation":46,"armGroups":56,"interventions":69,"overallOfficials":46,"centralContacts":79,"locations":85,"responsibleParty":123,"collaborators":46,"id":125,"slug":126,"hasResults":127,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":46,"eligibilityCriteria":131,"healthyVolunteers":127,"sex":132,"minAge":133,"maxAge":46,"enrollmentInfo":134,"targetDuration":46,"studyType":137,"phases":138,"briefSummary":140,"conditions":141,"keywords":46,"overallStatus":110,"whyStopped":46,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":153},{"fullName":5,"class":6},"The Hong Kong Polytechnic University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":46},[9],{"measure":10,"description":11,"timeFrame":12},"Muscle Strength","Isometric knee extensor strength of the paretic limb will be assessed using an isokinetic dynamometer at 60 degrees of knee flexion. The primary variable will be peak torque, recorded in Newton-meters (N·m). Higher values indicate greater knee extensor strength.","baseline (prior to intervention), 6 weeks post-intervention (End), and 6 weeks after the end of the intervention (Follow-up)",[14,17,20,24,27,31,34,37,40,43],{"measure":15,"description":16,"timeFrame":12},"Nutritional Status - Mini Nutritional Assessment Short Form (MNA-SF)","Nutritional status will be evaluated using the Mini Nutritional Assessment - Short Form (MNA-SF), a validated screening tool for identifying malnutrition or risk of malnutrition in older adults. The total score ranges from 0 to 14. Scores ≥12 indicate normal nutritional status, 8-11 at risk, and ≤7 malnourished.",{"measure":18,"description":19,"timeFrame":12},"Quality of Life - Sarcopenia and Quality of Life Questionnaire (SarQoL)","Quality of life related to sarcopenia will be assessed using the Sarcopenia and Quality of Life Questionnaire (SarQoL), a disease-specific instrument for older adults with reduced muscle mass or function. It covers domains such as physical health, mental health, locomotion, and daily activities. Higher scores indicate better quality of life.",{"measure":21,"description":22,"timeFrame":23},"Appendicular Skeletal Muscle Mass (ASM)","ASM will be assessed using bioelectrical impedance analysis (BIA) and reported in kilograms per square meter (kg\u002Fm²). This value is calculated as total limb lean mass divided by height squared, following the AWGS 2019 criteria.","Baseline, Week 6, Week 12",{"measure":25,"description":26,"timeFrame":23},"Muscle Thickness (MT)","Muscle thickness will be measured using B-mode ultrasonography with a high-frequency linear probe. Values will be reported in millimeters (mm). The average of three measurements will be used for each muscle. Muscle Thickness of Rectus Femoris and Medial Gastrocnemius.",{"measure":28,"description":29,"timeFrame":30},"Six-Minute Walk Distance","Walking endurance will be assessed using the 6-Minute Walk Test. Participants will be instructed to walk as far as possible along a level indoor walkway within 6 minutes. The total distance covered will be recorded in meters. Higher values indicate better walking endurance.","Baseline, Week 6, and Week 12",{"measure":32,"description":33,"timeFrame":30},"Berg Balance Scale","Balance ability will be assessed using the Berg Balance Scale, which includes 14 functional balance tasks. Each item is scored from 0 to 4, with a total score ranging from 0 to 56. Higher scores indicate better balance performance.",{"measure":35,"description":36,"timeFrame":30},"Timed Up and Go Test","Functional mobility will be assessed using the Timed Up and Go Test. Participants will rise from a chair, walk 3 meters, turn around, walk back, and sit down. The time required to complete the task will be recorded in seconds. Lower values indicate better functional mobility.",{"measure":38,"description":39,"timeFrame":30},"Five-Times Sit-to-Stand Test","Lower-limb functional strength will be assessed using the Five-Times Sit-to-Stand Test. Participants will be instructed to stand up from a standard chair and sit down five times as quickly as possible without using their arms. The time required to complete the test will be recorded in seconds. Lower values indicate better lower-limb functional performance.",{"measure":41,"description":42,"timeFrame":30},"Cross-Sectional Area","Medial gastrocnemius cross-sectional area will be assessed using B-mode ultrasonography on transverse images. The muscle boundary will be manually traced, and cross-sectional area will be reported in square centimeters (cm²). Higher values indicate greater muscle cross-sectional area.Rectus femoris cross-sectional area will be assessed using B-mode ultrasonography on transverse images. The muscle boundary will be manually traced, and cross-sectional area will be reported in square centimeters (cm²). Higher values indicate greater muscle cross-sectional area.",{"measure":44,"description":45,"timeFrame":30},"Gait speed","Maximum gait speed will be assessed using the 6-Meter Gait Speed Test. Participants will be instructed to walk a straight 6-meter distance as fast as safely possible. The time required to complete the 6-meter distance will be recorded, and gait speed will be calculated as distance divided by time and reported in meters per second (m\u002Fs). Higher values indicate faster walking speed and better walking performance.",null,{"allocation":48,"interventionModel":49,"interventionModelDescription":46,"primaryPurpose":50,"observationalModel":46,"timePerspective":46,"maskingInfo":51},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":52,"maskingDescription":46,"whoMasked":53},"DOUBLE",[54,55],"PARTICIPANT","OUTCOMES_ASSESSOR",[57,63],{"label":58,"type":59,"description":60,"interventionNames":61},"BFR Walking Group","EXPERIMENTAL","Participants in this group will receive blood flow restriction (BFR) walking training. Pneumatic cuffs will be applied proximally to both thighs. Walking sessions will be conducted on a treadmill at 60% of each participant's maximal gait speed for 20 minutes per session, 3 sessions per week, for 6 weeks. Cuff pressure will be progressively increased from 140 mmHg in Week 1 to a maximum of 200 mmHg in Week 6, according to individual tolerance. Vital signs and symptoms will be monitored throughout each session.",[62],"Procedure: Blood Flow Restriction (BFR) Walking",{"label":64,"type":65,"description":66,"interventionNames":67},"Sham-BFR Walking Group","SHAM_COMPARATOR","Participants in this group will receive sham blood flow restriction walking training. Pressure cuffs will be applied to the proximal thighs but only inflated to 20 mmHg, which does not restrict blood flow. Walking sessions will be performed under the same treadmill conditions as the BFR group (60% of maximum walking speed, 3 sessions per week for 6 weeks).",[68],"Procedure: Sham Blood Flow Restriction (Sham-BFR) Walking",[70,75],{"type":71,"name":72,"description":73,"armGroupLabels":74,"otherNames":46},"PROCEDURE","Blood Flow Restriction (BFR) Walking","Participants in this group will undergo a supervised treadmill walking program with blood flow restriction (BFR) applied using BFR pressure cuffs. The cuffs are applied to the proximal thighs, and the training pressure starts at 50% of the participant's arterial occlusion pressure (AOP), increasing every two weeks up to 200 mmHg. Walking is performed at 60% of the maximum walking speed, 20 minutes per session, 3 sessions per week for 6 weeks.",[58],{"type":71,"name":76,"description":77,"armGroupLabels":78,"otherNames":46},"Sham Blood Flow Restriction (Sham-BFR) Walking","Participants in this group will follow the same supervised treadmill walking protocol as the BFR group but with minimal cuff pressure (20 mmHg), which does not restrict blood flow. This simulates the sensation of BFR without physiological impact. The purpose is to serve as a placebo comparator. Walking is performed at 60% of maximum walking speed, 20 minutes per session, 3 sessions per week for 6 weeks.",[64],[80],{"name":81,"role":82,"phone":83,"phoneExt":46,"email":84},"Yingxiu Diao, Master","CONTACT","+8614796733917","24039355r@connect.polyu.hk",[86,109],{"facility":87,"status":88,"city":89,"state":90,"zip":91,"country":92,"countryCode":93,"cosmosGeoPoint":94,"geoPoint":99,"contacts":100},"Hong Kong Polytechnic University","NOT_YET_RECRUITING","Hung Hom","Kowloon","999077","Hong Kong","HK",{"type":95,"coordinates":96},"Point",[97,98],114.18532,22.30715,{"lat":98,"lon":97},[101,103,107],{"name":81,"role":82,"phone":102,"phoneExt":46,"email":84},"8614796733917",{"name":104,"role":82,"phone":105,"phoneExt":46,"email":106},"Yarou Yuan, Master","90495235","sabrina.yuan@connect.polyu.hk",{"name":81,"role":108,"phone":46,"phoneExt":46,"email":46},"SUB_INVESTIGATOR",{"facility":87,"status":110,"city":89,"state":90,"zip":91,"country":92,"countryCode":93,"cosmosGeoPoint":111,"geoPoint":113,"contacts":114},"RECRUITING",{"type":95,"coordinates":112},[97,98],{"lat":98,"lon":97},[115,119,120],{"name":116,"role":82,"phone":117,"phoneExt":46,"email":118},"Jingquan Cai, Master","+85294149862","kingston.cai@polyu.edu.hk",{"name":81,"role":108,"phone":46,"phoneExt":46,"email":46},{"name":121,"role":122,"phone":46,"phoneExt":46,"email":46},"Marco Pang, PhD","PRINCIPAL_INVESTIGATOR",{"type":124,"investigatorFullName":46,"investigatorTitle":46,"investigatorAffiliation":46,"oldNameTitle":46,"oldOrganization":46},"SPONSOR","100590979","effects-of-blood-flow-restriction-training-on-muscle-strength-and-physical-function-for-stroke-related-sarcopenia-100590979",false,"NCT06974461","Effects of Blood Flow Restriction Training on Muscle Strength and Physical Function for Stroke-Related Sarcopenia","Effects of Blood Flow Restriction Training on Physical Performance in Individuals With Stroke-Related Sarcopenia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosed with chronic stroke (≥6 months post-stroke)\n* Sarcopenia will be diagnosed using the Asian Working Group for Sarcopenia (AWGS) 2025 criteria, defined as the concurrent presence of low muscle strength and low appendicular skeletal muscle mass. Muscle strength will be assessed using handgrip strength measured on the non-paretic side. Low muscle strength will be defined as handgrip strength \\\u003C28 kg for men and \\\u003C18 kg for women aged ≥65 years, and \\\u003C34 kg for men and \\\u003C20 kg for women aged 50-64 years. Appendicular skeletal muscle mass will be measured using bioelectrical impedance analysis, and the appendicular skeletal muscle mass index will be calculated as appendicular skeletal muscle mass divided by height squared. Low muscle mass will be defined as an appendicular skeletal muscle mass index \\\u003C7.0 kg\u002Fm² for men and \\\u003C5.7 kg\u002Fm² for women aged ≥65 years, and \\\u003C7.6 kg\u002Fm² for men and \\\u003C5.7 kg\u002Fm² for women aged 50-64 years.\n\nExclusion Criteria:\n\n* Stroke occurred within the past 6 months\n* Resting systolic blood pressure \\> 200 mmHg\n* Resting diastolic blood pressure \\> 100 mmHg\n* Presence of implanted electronic or metallic devices that interfere with blood flow restriction cuffs\n* Contraindication to bioelectrical impedance analysis (e.g., pacemaker, ICD)","ALL","50 Years",{"count":135,"type":136},64,"ESTIMATED","INTERVENTIONAL",[139],"NA","Effects of Blood Flow Restriction Walking on Muscle Strength and Physical Function in Chronic Stroke Patients with Sarcopenia: A Randomized, Sham-Controlled Trial Primary Objective: To evaluate the effects of BFR walking on muscle strength and physical function in chronic stroke patients with sarcopenia, compared to sham-BFR walking.\n\nSecondary Objective: (1) To explore the potential impact of BFR walking on muscle mass and vascular function in chronic stroke patients with sarcopenia. (2) To assess the influence of BFR walking on quality of life in chronic stroke patients with sarcopenia.",[142,143],"Sarcopenia","Chronic Stroke Patients","2026-08-21",{"date":146,"type":147},"2026-08-24","ACTUAL",{"date":149,"type":147},"2025-09-01",{"date":151,"type":136},"2027-12-28",{"name":5,"class":6},2]