[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645422":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":19,"responsibleParty":31,"collaborators":19,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":19,"eligibilityCriteria":39,"healthyVolunteers":40,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":19,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":19,"overallStatus":53,"whyStopped":19,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":19},{"fullName":5,"class":6},"Swiss Federal Institute of Technology","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Gas perturbations","EXPERIMENTAL","Each participant will be tested on 4 different days, on each day with a different inspiratory gas mixture applied for 2h.",[13],"Other: Gas perturbation",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Gas perturbation","Participants will be breathing a gas mixture of either room air, or hypoxia, or hypercapnia, or a combination of both during 2h. This is followed by an all-out breathing exercise test against a small resistance, while still being in the respective gas condition.",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Spengler M. Christina, Prof.","Exercise Physiology Lab, Department of Health Sciences and Technology","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":19,"email":30},"Christina M. Spengler, Prof.","CONTACT","+41 44 632 5007","christina.spengler@hest.ethz.ch",{"type":32,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100645422","effects-of-blood-gas-perturbations-100645422",false,"NCT07701603","Effects of Blood Gas Perturbations","Effects of Blood Gas Perturbations on Neuromuscular Function of the Diaphragm and Lower Limbs at Rest and During Exercise.","Inclusion Criteria:\n\n* healthy\n* non.smoking\n* normal lung function\n* BMI: 18.5-29.9 kg\u002Fm2\n* willing to adhere to study rules\n\nExclusion Criteria:\n\n* Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep\n* Intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep\n* Any metal or electronics inside of the body\n* Presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators\n* History of seizures or epilepsy\n* Tattoos on the stimulation sites\n* Previous enrolment in this study\n* For women: Pregnancy, breastfeeding, or intention to become pregnant during the study",true,"ALL","18 Years","55 Years",{"count":45,"type":46},16,"ESTIMATED","INTERVENTIONAL",[49],"NA","In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.",[52],"Healthy","NOT_YET_RECRUITING","2026-07-08",{"date":56,"type":57},"2026-07-14","ACTUAL",{"date":59,"type":46},"2026-08-31",{"date":61,"type":46},"2029-12-31",{"name":5,"class":6}]