[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652028":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":40,"responsibleParty":60,"collaborators":62,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":25,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":25,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"North Carolina Agriculture & Technical State University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"High-Flavonoid Diet, Then Low-Flavonoid Diet","EXPERIMENTAL","All participants will first complete a 2-week low-flavonoid wash-in period. Participants in this sequence will then consume the high-flavonoid diet for 3 weeks, complete a 3-week low-flavonoid washout period, and then consume the low-flavonoid diet for 3 weeks.",[13,14],"Dietary Supplement: High-Flavonoid Diet","Dietary Supplement: Low-Flavonoid Diet",{"label":16,"type":10,"description":17,"interventionNames":18},"Low-Flavonoid Diet Followed by High-Flavonoid Diet","All participants will first complete a 2-week low-flavonoid wash-in period. Participants in this sequence will then consume the low-flavonoid diet for 3 weeks, complete a 3-week low-flavonoid washout period, and then consume the high-flavonoid diet for 3 weeks.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","High-Flavonoid Diet","Participants will consume the high-flavonoid diet daily for 3 weeks. The diet includes 1 Red Delicious apple (approximately 160 g), freeze-dried whole blueberry powder (25 g), soy milk (240 mL), and decaffeinated Lipton green tea ( 2 g tea leaves), providing approximately 420 mg flavonoids per day.",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Low-Flavonoid Diet","Participants will consume the low-flavonoid diet daily for 3 weeks. The diet includes 1\u002F3 of Red Delicious, 107 g of pineapple; 8.3 g of blueberry powder plus 16.7 g of blueberry placebo powder; 80 mL of soy milk plus 160 mL of 2% low-fat milk; and 0.67 g tea leaves, providing approximately 140 mg flavonoids per day.",[9,16],[31],{"name":32,"affiliation":33,"role":34},"Shengmin Sang","North Carolina A&T State University Principal Investigator","PRINCIPAL_INVESTIGATOR",[36],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","704-250-5710","ssang@ncat.edu",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"North Carolina Agriculture and Technical State University\u002F NRI Building","RECRUITING","Kannapolis","North Carolina","28081","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-80.62173,35.48736,{"lat":53,"lon":52},[56],{"name":57,"role":37,"phone":58,"phoneExt":25,"email":59},"Samantha Caroll","7047013024","samantha_carroll@unc.edu",{"type":34,"investigatorFullName":32,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Distinguished Professor",[63],{"name":64,"class":65},"National Institutes of Health (NIH)","NIH","100652028","effects-of-flavonoid-foods-on-carbonyl-stress-100652028",false,"NCT07767149","Effects of Flavonoid Foods on Carbonyl Stress","Effects of Flavonoid-rich Foods on Carbonyl Stress","Inclusion Criteria:\n\n* 1\\. Age 25-70 years 2. BMI between 18 and 30 3. Have no known allergy to test food 4. have no known allergies to green tea, apples, blueberries, soy milk, and pineapples 5. Be not engaging in high-intensity exercise 6. Having blood and urine clinical tests in the normal range. 7. Be not taking antibiotics for six months 8. Be not currently taking medication\n\n  1. No taking any prescription drugs\n  2. If supplements were taken, flavonoid-enriched supplements (see list below) should be avoided.\n\n     Major brands Notes Soy Isoflavones All flavonoid-enriched supplements should be avoided. Lipo-Flavonoid Citrus Bioflavonoids Complex Super Flavonoids Super Antioxidants Quercetin Supplement Essential-C and flavonoids Milk Thistle Other flavonoids supplements, including but not limited: Luteolin, Rutin, etc\n  3. No any drugs or supplements within three weeks of the experiment 9. Be nonsmoking 10. Have no alcoholic intoxication\n\n  \u003C!-- -->\n\n  1. No alcoholic addiction\n  2. \\\u003C 3-4 drinks per week (less than 2 glasses (300 mL) per drink)\n  3. No alcohol within 3 three weeks of the experiment 11. Have no extended exposure to industrial wastes\n\nExclusion Criteria:\n\n* 1\\. Disease: gout, heart disease, peripheral vascular disease, degenerative kidney, degenerative liver, diabetes, GI disorders, or endocrine disorders 2. Cancer patients\n\n  1. Currently diagnosed cancer patients will be excluded.\n  2. Medication free for \\>2 years could be considered.",true,"ALL","25 Years","70 Years",{"count":78,"type":79},36,"ESTIMATED","INTERVENTIONAL",[82],"NA","This randomized crossover study will compare low- and high-flavonoid diets in healthy adults to identify flavonoid-derived biomarkers in urine and plasma. Using targeted LC-MS metabolomics, researchers will measure known and novel flavonoid metabolites and evaluate whether a higher flavonoid intake reduces carbonyl stress markers, including reactive carbonyl species (RCS) and advanced glycation end products (AGEs).",[85,86,87],"Human Health","Flavonoids","Carbonyl Stress",[89,90,91,92,93],"flavonoids","Carbonyl stress","Advanced glycation end products (AGEs)","Metabolomics","Reactive carbonyl species (RCS)","2026-08-11",{"date":96,"type":97},"2026-08-17","ACTUAL",{"date":99,"type":79},"2026-09-02",{"date":101,"type":79},"2027-12-31",{"name":5,"class":6},1]