[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646570":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":45,"responsibleParty":62,"collaborators":43,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":43,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":43,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":87,"whyStopped":43,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Capital Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"RSO Group (Rapeseed Oil)","PLACEBO_COMPARATOR","Participants with obesity and mild cognitive impairment (MCI) will be provided with conventional rapeseed oil (RSO), in which diacylglycerol (DAG) occurs only at the low level naturally present in regular cooking oil (predominantly triacylglycerol), for household use for 6 months. Dietary guidance based on balanced nutrition principles will be provided. Compliance, dietary intake, anthropometric, biochemical, and cognitive assessments will be evaluated at baseline and 6 months.",[13],"Dietary Supplement: Rapeseed Oil (RSO)",{"label":15,"type":16,"description":17,"interventionNames":18},"DAG Group (Diacylglycerol Oil)","EXPERIMENTAL","Participants with obesity and MCI will be provided with rapeseed oil-based diacylglycerol (DAG) oil (DAG content ≥40%), produced from conventional rapeseed oil via lipase-catalyzed enzymatic conversion followed by distillation, deodorization, and decolorization, for household use for 6 months, replacing conventional cooking oil. Dietary guidance based on balanced nutrition principles will be provided. Compliance, dietary intake, anthropometric, biochemical, and cognitive assessments will be evaluated at baseline and 6 months.",[19],"Dietary Supplement: Diacylglycerol Oil (DAG Oil)",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Rapeseed Oil (RSO)","A commercially available conventional rapeseed oil for daily household cooking use, containing diacylglycerol (DAG) only at the trace level naturally occurring in regular vegetable oil.",[9],[27],"Conventional rapeseed oil",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Diacylglycerol Oil (DAG Oil)","A rapeseed oil-based functional oil produced via lipase-catalyzed enzymatic conversion, with a diacylglycerol content ≥40% (national standard requirement), for daily household cooking use in place of conventional cooking oil.",[15],[33],"Rapeseed oil-based DAG oil",[35],{"name":36,"affiliation":5,"role":37},"Rong Xiao, PhD","PRINCIPAL_INVESTIGATOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Jiaxuan Tao","CONTACT","+86-15389510275",null,"taojxxx@163.com",[46],{"facility":5,"status":43,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Beijing","Beijing Municipality","100069","China","CN",{"type":53,"coordinates":54},"Point",[55,56],116.39723,39.9075,{"lat":56,"lon":55},[59],{"name":36,"role":41,"phone":60,"phoneExt":43,"email":61},"+86-18611314617","xiaor22@ccmu.edu.cn",{"type":37,"investigatorFullName":40,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Doctoral student","100646570","effects-of-functional-oils-on-obesity-with-mild-cognitive-impairment-100646570",false,"NCT07690384","Effects of Functional Oils on Obesity With Mild Cognitive Impairment","Interventional Study of Functional Oils Improving Obesity With Mild Cognitive Impairment Via Regulating White Adipose Tissue Browning","Inclusion Criteria:\n\n* Meets the diagnostic criteria for obesity combined with mild cognitive impairment (MCI) (obesity: BMI ≥28.0 kg\u002Fm\\^2 per the 2022 Chinese Expert Consensus on Obesity Prevention and Treatment; MCI: Montreal Cognitive Assessment \\[MoCA\\] score below the education-adjusted cutoff, confirmed by a neurologist)\n* Aged 45 to 75 years\n* Has not been on a diet or has discontinued dieting for at least 3 months, and has not taken fish oil or similar supplements, or is willing to discontinue such supplements for 3 months prior to the intervention\n* Able to accept and consume DAG oil as part of daily diet\n* Voluntarily agrees to participate and signs the informed consent form\n\nExclusion Criteria:\n\n* History of neuropsychiatric disorders such as stroke, epilepsy, or schizophrenia\n* Cognitive impairment attributable to depression, thyroid disease, traumatic brain injury, or drug- or alcohol-induced intoxication\n* History of cerebrovascular disease, or cognitive decline due to severe impairment of cardiac, hepatic, pulmonary, or renal function\n* Use of antibiotics, health products, or nutritional supplements within 2 weeks prior to fecal sample collection; or gastrointestinal symptoms (trauma, inflammation\u002Finfection, abdominal pain, diarrhea, or constipation) or vaccination history within the same period","ALL","45 Years","75 Years",{"count":75,"type":76},100,"ESTIMATED","INTERVENTIONAL",[79],"NA","The purpose of this study is to investigate the effects of diacylglycerol (DAG) oil on obesity accompanied by mild cognitive impairment (MCI). Participants aged 45 to 75 years with obesity and MCI will be randomly assigned to two groups: a control group receiving regular rapeseed oil (RSO) and an experimental group receiving rapeseed-based DAG oil. The dietary intervention will last for 6 months. The main goal is to observe whether this functional oil intervention can improve cognitive function and regulate white adipose tissue browning.",[82,83],"Obesity","Mild Cognitive Impairment",[85,86],"Functional Oil","Dietary Intervention","NOT_YET_RECRUITING","2026-07-05",{"date":90,"type":91},"2026-07-08","ACTUAL",{"date":93,"type":76},"2026-07",{"date":95,"type":76},"2027-03",{"name":5,"class":6},1]