[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648745":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":28,"locations":38,"responsibleParty":54,"collaborators":56,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":20,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":40,"whyStopped":20,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"UConn Health","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Hard Gum Chewing Intervention","EXPERIMENTAL","Participants will perform a standardized hard-gum chewing protocol every other day for 4 weeks. Each session will last approximately 16 minutes and will follow a predefined chewing regimen. Three-dimensional facial images (3dMD) will be obtained at baseline (T0), immediately after the intervention period (T1), and after a 4-5-week washout period (T2) to evaluate changes in facial morphology.",[13],"Behavioral: Hard Gum Chewing",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Hard Gum Chewing","Participants will chew a standardized hard chewing gum (Jawliner®, hard hardness level) every other day for 4 weeks. Each session will consist of two 8-minute chewing blocks following a standardized protocol with controlled chewing pace, progressive force application, and alternating chewing sides. Total chewing time per session will be approximately 16 minutes.",[9],null,[22,26],{"name":23,"affiliation":24,"role":25},"Flavio Uribe","UConn School of dental medicine","PRINCIPAL_INVESTIGATOR",{"name":27,"affiliation":24,"role":25},"Thais Fernandes Poleti, PhD",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":20,"email":33},"Flavio Uribe (Chair, Depto Orthodontics; UConn School of dental medic","CONTACT","860-679-3170","furibe@uchc.edu",{"name":35,"role":31,"phone":36,"phoneExt":20,"email":37},"Georgiana Defilio","(860) 679-2550","GEDEFILIO@uchc.edu",[39],{"facility":5,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Farmington","Connecticut","06030","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-72.83204,41.71982,{"lat":50,"lon":49},[53],{"name":23,"role":31,"phone":20,"phoneExt":20,"email":20},{"type":25,"investigatorFullName":23,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Chair, Orthodontics UConn School of Dental Medicine",[57],{"name":58,"class":59},"Charles Burstone Foundation","UNKNOWN","100648745","effects-of-hard-gum-chewing-on-facial-soft-tissue-morphology-100648745",false,"NCT07726511","Effects of Hard Gum Chewing on Facial Soft Tissue Morphology","The Effect of Intentional Hard Gum Chewing on Facial Morphology: a 3DMD-based Analysis x","GUM-3D","Inclusion Criteria:\n\n* Healthy, non-smoking adults.\n* Age 20 to 40 years.\n* Presence of a full dentition from central incisor to first molar in all four quadrants, excluding second molars.\n* Stable occlusion with no ongoing orthodontic treatment or myofunctional therapy.\n* Ability and willingness to comply with the prescribed hard-gum chewing regimen for 4 weeks and attend all study visits.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Age younger than 20 years or older than 40 years.\n* Evident facial asymmetry from a frontal view.\n* Signs or symptoms of temporomandibular disorders (TMD) according to the Diagnostic Criteria for TMD (DC\u002FTMD).\n* Less than the normal range of condylar motion during maximum opening and closing.\n* Parafunctional habits such as bruxism with pain, clenching, or habitual gum chewing for more than 1 hour per day.\n* History of major craniofacial trauma, orthognathic surgery, or congenital craniofacial anomalies.\n* Ongoing orthodontic treatment or recent removal of fixed appliances (\\\u003C6 months).\n* Significant malocclusion or missing teeth in the anterior or premolar-first molar region that may affect mastication.\n* Systemic diseases or medications affecting muscle or bone metabolism.\n* Previous use of botulinum toxin (Botox) within the last 6 months or anticipated use during the study period.\n* Pregnancy or lactation.\n* Allergy or intolerance to the chewing gum ingredients.","ALL","20 Years","40 Years",{"count":72,"type":73},20,"ESTIMATED","INTERVENTIONAL",[76],"NA","This pilot clinical trial will evaluate whether intentional chewing of a standardized hard chewing gum for 4 weeks produces measurable changes in facial morphology in healthy adults. Twenty participants aged 20-40 years will undergo three-dimensional facial imaging (3dMD) at baseline (T0), after the 4-week chewing intervention (T1), and following a 4-5-week washout period (T2). Changes in facial soft-tissue morphology will be assessed using three-dimensional surface analysis, including heatmaps, regional surface displacement, and morphometric measurements. Secondary outcomes include self-reported muscle fatigue, soreness, adherence, and temporomandibular disorder (TMD) symptoms.",[79],"Face",[17,81,82,83,84,85,86,87,88,89],"Facial Morphology","3dMD","Stereophotogrammetry","Facial Soft Tissue","Heatmap Analysis","Chewing Gum","Masticatory Muscles","Three-Dimensional Imaging","Surface Distance Mapping","2026-07-22",{"date":92,"type":93},"2026-07-24","ACTUAL",{"date":95,"type":93},"2026-06-03",{"date":97,"type":73},"2028-06-30",{"name":5,"class":6},1]