[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649891":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":64,"collaborators":26,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":95,"whyStopped":26,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Riphah International University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Inspiratory Muscle Training (IMT) + Conventional Knee OA Physiotherapy","EXPERIMENTAL","Participants will receive conventional knee osteoarthritis physiotherapy twice weekly for 6 weeks along with Inspiratory Muscle Training (IMT) using a POWERbreathe device. IMT will consist of 30 quick breaths twice daily at approximately 50% of baseline maximal inspiratory pressure (MIP), progressively increased up to 35 breaths according to patient tolerance. Conventional treatment includes knee isometric exercises, open-chain strengthening exercises, static stretching, and Maitland Grade I-II anterior-posterior mobilizations.",[13],"Device: POWERBREATH",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham IMT + Conventional Knee OA Physiotherapy","SHAM_COMPARATOR","Participants will receive conventional knee osteoarthritis physiotherapy twice weekly for 6 weeks along with sham inspiratory muscle training using a POWERbreathe device. Sham training will consist of 60 slow breaths once daily at load setting zero (approximately 15% of baseline MIP). The load adjuster will be fixed with adhesive tape to prevent resistance progression. Conventional treatment will be identical to the experimental group",[19],"Device: SHAM IMT",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","POWERBREATH","The POWERBREATH devices utilize calibrated resistance valves to force your breathing muscles to work harder, which naturally builds their power, stamina, and efficiency. IMT through POWERbreathe\n\n* 30 quick breaths two times a day at an adjustable resistance (equivalent to∼50% of (baseline) MIP).\n* Increased up to 35 breaths as per patient's tolerance.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"SHAM IMT","* 60 slow breaths once daily at a load setting of 0 (corresponding to∼15% (baseline) MIP).\n* Training load adjustment was prevented using sticky tape applied to the device's load adjuster.",[15],[32],{"name":33,"affiliation":5,"role":34},"Dr. Suman Sheraz, PhD","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Dr. Suman Sheraz, Phd","CONTACT","03335646361","suman.sheraz@riphah.edu.pk",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Dr. Imran Amjad, Phd","03324390125","imran.amjad@riphah.edu.pk",[46],{"facility":47,"status":26,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"IIMCT Railway general hospital","Rawalpindi","Punjab Province","46060","Pakistan","PK",{"type":54,"coordinates":55},"Point",[56,57],73.0479,33.59733,{"lat":57,"lon":56},[60,62],{"name":61,"role":38,"phone":39,"phoneExt":26,"email":40},"Dr Suman Sheraz, PhD",{"name":63,"role":38,"phone":43,"phoneExt":26,"email":44},"Dr Imran Amjad, PhD",{"type":65,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100649891","effects-of-imt-on-cardiopulmonary-endurance-and-functional-mobility-in-koa-100649891",false,"NCT07738627","Effects of IMT on Cardiopulmonary Endurance and Functional Mobility in KOA","Inspiratory Muscle Training as an Adjunct to Standard Care: Effects on Cardiopulmonary Endurance and Functional Mobility in Knee Osteoarthritis","IMT","Inclusion Criteria:\n\n* Age 40-65 years\n* Male and Female participants\n* Bilateral Knee Osteoarthritis\n* Diagnosed according to American College of Rheumatology criteria\n* Kellgren and Lawrence Grade II-III\n* Able to walk independently\n* Willing to provide informed consent\n\nExclusion Criteria:\n\n* Participation in structured physical activity programs\n* Intra-articular corticosteroid injection within last 3 months\n* Hyaluronic acid injection within last 6 months\n* Lower limb trauma or surgery history\n* Planned surgery during study period\n* Severe cardiovascular disease\n* Severe pulmonary disease\n* Neurological disorders\n* Psychological disorders","ALL","40 Years","65 Years",{"count":78,"type":79},65,"ESTIMATED","INTERVENTIONAL",[82],"NA","The purpose of the study is to investigate whether adding Inspiratory Muscle Training (IMT) to the usual treatment of patients with knee osteoarthritis improves their cardiopulmonary endurance and functional mobility more than standard care alone.",[85],"Knee Osteoarthritis",[85,87,88,89,90,91,92,93,94],"Inspiratory Muscle Training","Cardiopulmonary Endurance","Aerobic capacity","Respiratory Muscle Strength","Functional Mobility","6-Minute Walk Test","WOMAC","TUG Test","NOT_YET_RECRUITING","2026-08-05",{"date":98,"type":99},"2026-08-07","ACTUAL",{"date":101,"type":79},"2026-08",{"date":103,"type":79},"2027-12-11",{"name":5,"class":6},1]