[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652762":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":31,"studyPopulation":23,"armGroups":32,"interventions":43,"overallOfficials":49,"centralContacts":54,"locations":59,"responsibleParty":73,"collaborators":23,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":78,"sex":84,"minAge":85,"maxAge":23,"enrollmentInfo":86,"targetDuration":23,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":98,"whyStopped":23,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University Maribor","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":23},[9],{"measure":10,"description":11,"timeFrame":12},"Change in gastrointestinal symptoms assessed by the Gastrointestinal Symptom Rating Scale (GSRS)","Change in GSRS score between the kefir consumption period and the period without kefir. The GSRS is a validated questionnaire assessing gastrointestinal symptoms.","Baseline, after each 4-week intervention period, and after the 4-week washout period",[14,17,20],{"measure":15,"description":16,"timeFrame":12},"Celiac disease-related quality of life assessed by the Celiac Disease Quality of Life questionnaire (CD-QOL)","Change in CD-QOL score between the kefir consumption period and the period without kefir.",{"measure":18,"description":19,"timeFrame":12},"Stool consistency assessed by the Bristol Stool Form Scale (BSFS)","Change in stool consistency assessed using the Bristol Stool Form Scale during the kefir consumption period compared with the period without kefir.\n\nTime Frame",{"measure":21,"description":22,"timeFrame":12},"Adherence to a gluten-free diet assessed by the Celiac Dietary Adherence Test (CDAT)","Change in CDAT score between the kefir consumption period and the period without kefir.",null,{"allocation":25,"interventionModel":26,"interventionModelDescription":27,"primaryPurpose":28,"observationalModel":23,"timePerspective":23,"maskingInfo":29},"RANDOMIZED","CROSSOVER","Participants will be randomly assigned to one of two intervention sequences. Each participant will receive kefir consumption and a period of usual gluten-free diet without kefir, with a 4-week washout period between the two periods.","TREATMENT",{"masking":30,"maskingDescription":23,"whoMasked":23},"NONE","Celiac disease is a chronic autoimmune disease triggered by gluten consumption. Although a strict gluten-free diet is the only established treatment, some individuals continue to experience gastrointestinal symptoms and reduced quality of life.\n\nThe CeliKef study will investigate whether regular consumption of kefir may help alleviate gastrointestinal symptoms and improve quality of life in adults with celiac disease following a strict gluten-free diet. The study will include approximately 30 participants and will use a randomized cross-over design. Each participant will undergo a kefir consumption period and a period without kefir, separated by a washout period. Gastrointestinal symptoms and celiac disease-related quality of life will be assessed during the study.",[33,39],{"label":34,"type":35,"description":36,"interventionNames":37},"Kefir first","EXPERIMENTAL","Participants randomized to this sequence will consume kefir daily for 4 weeks, followed by a 4-week washout period and then 4 weeks of their usual gluten-free diet without kefir.",[38],"Dietary Supplement: kefir",{"label":40,"type":35,"description":41,"interventionNames":42},"No Kefir First","Participants randomized to this sequence will follow their usual gluten-free diet without kefir for 4 weeks, followed by a 4-week washout period and then 4 weeks of daily kefir consumption.",[38],[44],{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":23},"DIETARY_SUPPLEMENT","kefir","Participants will consume 200 mL kefir prepared from starter cultures daily for 4 weeks. The kefir will be provided for the intervention period.",[34,40],[50],{"name":51,"affiliation":52,"role":53},"SABINA FIJAN, PhD","University of Maribor, Faculty of Health Sciences","PRINCIPAL_INVESTIGATOR",[55],{"name":51,"role":56,"phone":57,"phoneExt":23,"email":58},"CONTACT","+38623004755","sabina.fijan@um.si",[60],{"facility":52,"status":23,"city":61,"state":23,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Maribor","2000","Slovenia","SI",{"type":66,"coordinates":67},"Point",[68,69],15.64593,46.55583,{"lat":69,"lon":68},[72],{"name":51,"role":56,"phone":57,"phoneExt":23,"email":58},{"type":53,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Sabina Fijan","professor","100652762","effects-of-kefir-on-celiac-disease-100652762",false,"NCT07777666","Effects of Kefir on Celiac Disease","Effects of Kefir Consumption on Celiac Disease Symptoms","CeliKef","Inclusion Criteria:\n\n* Adults aged 18 years or older with a confirmed diagnosis of celiac disease.\n* Following a strict gluten-free diet.\n\nExclusion Criteria:\n\n* Other chronic gastrointestinal diseases.\n* Pregnancy.\n* Known allergy or intolerance to milk or dairy products or other components of kefir.","ALL","18 Years",{"count":87,"type":88},30,"ESTIMATED","INTERVENTIONAL",[91],"NA","This study will investigate whether regular consumption of kefir can reduce gastrointestinal symptoms and improve quality of life in adults with celiac disease who follow a strict gluten-free diet. The study will use a randomized cross-over design in which participants will consume kefir during one study period and continue their usual diet without kefir during another period.",[94],"Celiac Disease",[96,46,97],"celiac disease","gluten","NOT_YET_RECRUITING","2026-08-17",{"date":101,"type":102},"2026-08-20","ACTUAL",{"date":104,"type":88},"2026-09-30",{"date":106,"type":88},"2027-11-29",{"name":5,"class":6},1]