[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650871":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":18,"locations":10,"responsibleParty":24,"collaborators":10,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":33,"acronym":10,"eligibilityCriteria":34,"healthyVolunteers":35,"sex":36,"minAge":37,"maxAge":38,"enrollmentInfo":39,"targetDuration":10,"studyType":42,"phases":10,"briefSummary":43,"conditions":44,"keywords":10,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":53,"leadSponsor":55,"locationsCount":10},{"fullName":5,"class":6},"Recep Tayyip Erdogan University Training and Research Hospital","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Children Receiving Long-Term H1 Antihistamine Therapy",null,"Children aged 8-10 years who have been receiving H1 antihistamine therapy regularly for at least one year.",{"label":13,"type":10,"description":14,"interventionNames":10},"Allergic Children Without Antihistamine Therapy","Children aged 8-10 years diagnosed with allergic disease who have not received H1 antihistamine therapy during the previous year.",{"label":16,"type":10,"description":17,"interventionNames":10},"Healthy Controls","Age- and sex-matched healthy children without allergic disease or long-term antihistamine use.",[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"dilara nil günaçar","CONTACT","05412940104","dilaranil.tomrukcu@erdogan.edu.tr",{"type":25,"investigatorFullName":26,"investigatorTitle":27,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","DİLARA NİL GÜNAÇAR","Associate Professor","100650871","effects-of-long-term-antihistamine-use-on-mandibular-bone-in-children-100650871",false,"NCT07752485","Effects of Long-Term Antihistamine Use on Mandibular Bone in Children","Effects of Long-Term H1 Antihistamine Use on Mandibular Trabecular Bone Structure and Panoramic Mandibular Index in Children: A Retrospective Radiographic Study","Inclusion Criteria\n\n* Children aged 8 to 10 years.\n* Availability of a diagnostic-quality digital panoramic radiograph obtained as part of routine dental care.\n* Presence of complete mandibular permanent first molars and permanent incisors.\n* Belonging to one of the following study groups:\n* Children receiving regular H1 antihistamine therapy for at least 12 months.\n* Children diagnosed with an allergic disease who have not received H1 antihistamine therapy during the previous 12 months.\n* Healthy children without allergic disease or long-term antihistamine use.\n* Availability of complete medical and dental records. Exclusion Criteria\n* History of systemic diseases or conditions known to affect bone metabolism.\n* Use of medications affecting bone metabolism (other than H1 antihistamines in the antihistamine group).\n* Craniofacial anomalies or syndromes.\n* History of orthodontic treatment.\n* Previous mandibular trauma or surgery.\n* Presence of radiographic pathology affecting the mandibular regions of interest (e.g., cysts, tumors, fractures, or extensive bone lesions).\n* Poor-quality panoramic radiographs with positioning errors or artifacts that interfere with image analysis.\n* Missing permanent first molars or incomplete eruption of teeth required for the analysis.",true,"ALL","8 Years","10 Years",{"count":40,"type":41},84,"ESTIMATED","OBSERVATIONAL","The purpose of this retrospective radiographic study is to evaluate the effects of long-term H1 antihistamine use on mandibular trabecular bone structure in children aged 8-10 years. Mandibular trabecular bone will be assessed using fractal dimension analysis and the panoramic mandibular index on digital panoramic radiographs. Three groups will be compared: children receiving long-term H1 antihistamine therapy, allergic children without antihistamine use, and age- and sex-matched healthy controls. The findings will provide information on whether long-term antihistamine therapy is associated with alterations in mandibular bone microarchitecture.",[45,46],"Fractals","Panoramic Radiography","NOT_YET_RECRUITING","2026-08-03",{"date":50,"type":51},"2026-08-07","ACTUAL",{"date":48,"type":41},{"date":54,"type":41},"2026-09-03",{"name":5,"class":6}]