[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655304":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":22,"studyPopulation":22,"armGroups":32,"interventions":44,"overallOfficials":22,"centralContacts":54,"locations":64,"responsibleParty":79,"collaborators":22,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":22,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":22,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":108,"whyStopped":22,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Ankara Etlik City Hospital","OTHER_GOV",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":22},[9],{"measure":10,"description":11,"timeFrame":12},"Mean Arterial Pressure","Evaluation of Mean Arterial Pressure (MAP)","Baseline, at induction, and every 3 minutes until the end of the procedure",[14,18],{"measure":15,"description":16,"timeFrame":17},"Bispectral Index (BIS) Values","Objective assessment of sedation depth using the BIS monitor","Intraoperative (Continuous monitoring from baseline to the end of the procedure)",{"measure":19,"description":20,"timeFrame":21},"Total Propofol Consumption","Total amount of propofol (in mg) consumed to maintain adequate sedation (Ramsay Score 2-3)","At the end of the procedure",null,{"allocation":24,"interventionModel":25,"interventionModelDescription":22,"primaryPurpose":26,"observationalModel":22,"timePerspective":22,"maskingInfo":27},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":28,"maskingDescription":22,"whoMasked":29},"DOUBLE",[30,31],"PARTICIPANT","OUTCOMES_ASSESSOR",[33,39],{"label":34,"type":35,"description":36,"interventionNames":37},"Propofol Group","ACTIVE_COMPARATOR","Patients receiving standard propofol sedation according to routine clinical practice during elective colonoscopy",[38],"Procedure: Propofol group",{"label":40,"type":35,"description":41,"interventionNames":42},"Propofol + Ketamine Group","Patients receiving standard propofol sedation combined with low-dose ketamine (0.25 mg\u002Fkg) according to routine clinical practice during elective colonoscopy",[43],"Procedure: Propofol + Ketamine",[45,50],{"type":46,"name":47,"description":48,"armGroupLabels":49,"otherNames":22},"PROCEDURE","Propofol group","Patients in this group will receive standard propofol sedation titrated to achieve a Bispectral Index (BIS) of 60-80 and a Ramsay Sedation Score of 2-3 during elective colonoscopy",[34],{"type":46,"name":51,"description":52,"armGroupLabels":53,"otherNames":22},"Propofol + Ketamine","Patients in this group will receive a combination of standard propofol sedation and low-dose ketamine (0.25 mg\u002Fkg). Propofol will be titrated to achieve a Bispectral Index (BIS) of 60-80 and a Ramsay Sedation Score of 2-3 during elective colonoscopy",[40],[55,60],{"name":56,"role":57,"phone":58,"phoneExt":22,"email":59},"Berat DAĞDELEN","CONTACT","00905538861406","brtdagdelen@gmail.com",{"name":61,"role":57,"phone":62,"phoneExt":22,"email":63},"Aslı DÖNMEZ","00905322256473","aslidonmez@hotmail.com",[65],{"facility":5,"status":22,"city":66,"state":67,"zip":68,"country":69,"countryCode":22,"cosmosGeoPoint":70,"geoPoint":75,"contacts":76},"Altındağ","Ankara","06000","Turkey (Türkiye)",{"type":71,"coordinates":72},"Point",[73,74],32.92254,39.96673,{"lat":74,"lon":73},[77,78],{"name":56,"role":57,"phone":58,"phoneExt":22,"email":59},{"name":61,"role":57,"phone":62,"phoneExt":22,"email":63},{"type":80,"investigatorFullName":56,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Principal Investigator","100655304","effects-of-low-dose-ketamine-added-to-propofol-sedation-during-colonoscopy-100655304",false,"NCT07809230","Effects of Low-Dose Ketamine Added to Propofol Sedation During Colonoscopy","The Effects of Adding Low-Dose Ketamine to Propofol Sedation on Bispectral Index Values, Hemodynamic Stability, and Recovery Time in Patients Undergoing Colonoscopy","Inclusion Criteria:\n\n* Patients scheduled for elective colonoscopy\n* ASA physical status I-II\n\nExclusion Criteria:\n\n* ASA physical status ≥ III\n* Allergy to propofol or ketamine\n* History of psychiatric illness\n* Advanced cardiac disease\n* Pregnancy\n* Chronic use of opioids or sedatives\n* Inability to cooperate\n* Body Mass Index (BMI) \\> 35 kg\u002Fm\\^2","ALL","18 Years","65 Years",{"count":93,"type":94},100,"ESTIMATED","INTERVENTIONAL",[97],"NA","\"This prospective observational study aims to evaluate the effects of adding low-dose ketamine (0.25 mg\u002Fkg) to standard propofol sedation on hemodynamic stability, sedation depth, and recovery times in adult patients undergoing elective colonoscopy. Sedation depth will be objectively monitored using the Bispectral Index (BIS) alongside clinical scoring. The study observes and compares two standard sedation regimens routinely used in the clinic: propofol alone versus a combination of propofol and low-dose ketamine.\n\nResearchers will record intraoperative hemodynamic parameters (mean arterial pressure, heart rate, oxygen saturation) and BIS values at regular intervals from baseline to the end of the procedure. Furthermore, postoperative recovery quality, cognitive function, and discharge readiness will be comprehensively assessed using the Modified Aldrete Score, Post Anesthetic Discharge Scoring System (PADSS), and a computerized Psychomotor Vigilance Test (PVT-B) at specific time points. The total amount of propofol consumed to maintain adequate sedation will also be compared between the two observational cohorts.\"",[100,101],"Colonoscopy Procedures","Sedation",[103,104,105,106,107],"colonoscopy procedures","sedation","propofol","ketamine","bispectral index","NOT_YET_RECRUITING","2026-09-04",{"date":111,"type":112},"2026-09-09","ACTUAL",{"date":114,"type":94},"2026-09-14",{"date":116,"type":94},"2027-02-14",{"name":5,"class":6},1]