[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653361":3},{"organization":4,"outcomesModule":7,"designInfo":51,"detailedDescription":20,"studyPopulation":20,"armGroups":62,"interventions":80,"overallOfficials":20,"centralContacts":92,"locations":20,"responsibleParty":98,"collaborators":20,"id":100,"slug":101,"hasResults":102,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":108,"sex":109,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":20,"studyType":115,"phases":116,"briefSummary":118,"conditions":119,"keywords":20,"overallStatus":123,"whyStopped":20,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":20},{"fullName":5,"class":6},"University of Bergen","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"Joint inflammation","Inflammation will be assessed using three approaches: (1) The number of tender and swollen joints among the 28 joints included in the DAS28, a validated disease activity measure for rheumatoid arthritis; (2) ultrasound findings in tender and\u002For swollen joints; and (3) circulating levels of the inflammatory markers TNF-alpha and IL-6. Both the joint examination and ultrasound assessment will be performed by a rheumatologist. Ultrasound-detected synovitis will be assessed using the EULAR-OMERACT semiquantitative scoring system, with grey-scale synovitis and power Doppler signal graded from 0 to 3, where 0 represents the lowest grade and 3 the maximum grade.","Change between baseline and endpoint (6 months)",[14,18,22,24,27,30,33,36,39,41,43,45,47,49],{"measure":15,"description":16,"timeFrame":17},"Self-assessment of joint health using the RAID questionnaire","Study participants record their perceptions of their joint health, diet, and physical activity. A modified version of the validated Rheumatoid Arthritis Impact of Disease (RAID) questionnaire will be used to assess participants' self-reported joint health. The RAID comprises seven domains: pain, physical function, fatigue, sleep, physical well-being, emotional well-being, and coping. Each domain is rated on a 0-10 scale, with 0 indicating no symptoms and 10 representing the worst possible symptoms.","Change between baseline, 3 months and endpoint (6 months)",{"measure":19,"description":20,"timeFrame":21},"Concentration of interleukin-6 in blood",null,"Change between baseline, 3 months and endpoint (6 months).",{"measure":23,"description":20,"timeFrame":21},"Concentration of TNF-alpha in blood",{"measure":25,"description":26,"timeFrame":17},"Quantification of fatty acid contents in leucocytes","Leucocytes are isolated from heparine blood.",{"measure":28,"description":29,"timeFrame":17},"Serum concentration of total cholesterol","Total cholesterol is measured in fasting samples",{"measure":31,"description":32,"timeFrame":17},"Serum concentration of LDL-cholesterol","LDL-cholesterol is measured in fasting samples",{"measure":34,"description":35,"timeFrame":17},"Serum concentration of HDL-cholesterol","HDL-cholesterol is measured in fasting samples",{"measure":37,"description":38,"timeFrame":17},"Change from baseline in percent body fat","Percent body fat will be measured using bioimpedance",{"measure":40,"description":20,"timeFrame":12},"Serum concentrations of amino acid and their metabolites",{"measure":42,"description":20,"timeFrame":12},"Serum concentrations of one-carbon metabolites",{"measure":44,"description":20,"timeFrame":17},"Serum concentration of non-esterified fatty acids",{"measure":46,"description":20,"timeFrame":17},"Erythrocyte sedimentation rate",{"measure":48,"description":20,"timeFrame":12},"Serum concentration of anti-Cyclic Citrullinated Peptide",{"measure":50,"description":20,"timeFrame":12},"Serum concentration of rheumatoid factor",{"allocation":52,"interventionModel":53,"interventionModelDescription":20,"primaryPurpose":54,"observationalModel":20,"timePerspective":20,"maskingInfo":55},"RANDOMIZED","PARALLEL","BASIC_SCIENCE",{"masking":56,"maskingDescription":20,"whoMasked":57},"QUADRUPLE",[58,59,60,61],"PARTICIPANT","CARE_PROVIDER","INVESTIGATOR","OUTCOMES_ASSESSOR",[63,69,74],{"label":64,"type":65,"description":66,"interventionNames":67},"Herring oil","EXPERIMENTAL","Dietary supplement: herring oil in capsules, regular content of omega-11 MUFAs and omega-3 PUFAs, 4 g oil daily for 6 months",[68],"Dietary Supplement: Herring oil",{"label":70,"type":65,"description":71,"interventionNames":72},"Omega-11 concentrate produced from herring oil","Dietary supplement: omega-11 concentrate in capsules, containing mainly omega-11 MUFAs and omega-3 PUFAs, 4 g oil daily for 6 months",[73],"Dietary Supplement: Omega-11 concentrate produced from herring oi",{"label":75,"type":76,"description":77,"interventionNames":78},"Control oil","ACTIVE_COMPARATOR","Dietary supplement: control oil (fish oil) in capsules, containing omega-3 PUFAs but no omega-11 MUFAs, 4 g oil daily for 6 months",[79],"Dietary Supplement: Control oil",[81,85,89],{"type":82,"name":64,"description":83,"armGroupLabels":84,"otherNames":20},"DIETARY_SUPPLEMENT","Capsules containing herring oil concentrate, taken daily for 6 months.",[64],{"type":82,"name":86,"description":87,"armGroupLabels":88,"otherNames":20},"Omega-11 concentrate produced from herring oi","Capsules containing omega-11 concentrate, taken daily for 6 months",[70],{"type":82,"name":75,"description":90,"armGroupLabels":91,"otherNames":20},"Capsules containing a control oil, taken daily for 6 months.",[75],[93],{"name":94,"role":95,"phone":96,"phoneExt":20,"email":97},"Oddrun A Gudbrandsen, PhD","CONTACT","+4755585421","nkjgu@uib.no",{"type":99,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100653361","effects-of-maine-oils-on-joint-stiffness-and-pain-100653361",false,"NCT07786181","Effects of Maine Oils on Joint Stiffness and Pain","A Study on the Effect of Consuming Marine Oils on Joint Stiffness and Joint Pain in Adults. A Randomised Double-blind Controlled Clinical Trial.","MAR-LEDD","Inclusion Criteria:\n\n* Adults (50-75 years)\n* Mild to moderate joint pain for at least 3 months\n* Stable body weight last 3 months\n\nExclusion Criteria:\n\n* Diagnosed reumatic disease\n* Allergies towards fish, milk, egg, gluten\n* Daily tobacco use (cigarettes or snus)\n* Serious illness (cardiovascular disease, neurological disease, cancer, diseases affecting intestinal function, kidney function or insulin secretion)\n* Use of medications targeting cholesterol or glucose metabolism\n* Use of dietary supplements\n* Pregnant or breastfeeding\n* Following a strict diet\n* Had bariatric surgery or using medications for weight loss\n* Recent or planned surgical procedures\n* High intake of fish\u002Fseafood",true,"ALL","50 Years","75 Years",{"count":113,"type":114},150,"ESTIMATED","INTERVENTIONAL",[117],"NA","Joint pain has a negative effect on quality of life by limiting daily physical activity, and can lead to reduced work capacity, chronic stress, sleep problems, fatigue and reduced social life. Many people with joint pain find that taking fish oils reduces joint pain, and this may be related to an anti-inflammatory effect of omega-3 polyundaturated fatty acids (PUFAs). The investigators have recently shown that another group of fatty acids, that is, omega-11 monounsaturated fatty acids (MUFAs), have a strong anti-inflammatory effect in rats with chronic inflammation. Therefore, the investigators want to continue researching health effects of omega-11 MUFAs and investigate whether an anti-inflammatory effect can also be observed in people with joint pain. Omega-11 MUFAs including cetoleic acid (C22:1n-11) are found in high amounts in oils from certain fish species such as herring. In this study the effects of marine oils given as supplements (capsules) will be investigated in adults with joint pain, with particular focus on changes in pain and stiffness in joints and on levels of selected inflammation markers in blood samples. The study has three arms; one group receives herring oil with regular content of omega-11 MUFAs, one group receives herring oil with high content of omega-11 MUFAs, and a third group receives a commercail fish oil that does contain omega-11 MUFAs. The omega-3 content is similar in all intervention capsule types.",[120,121,122],"Joint Pain","Joint Stiffness","Joint Function","NOT_YET_RECRUITING","2026-08-21",{"date":126,"type":127},"2026-08-25","ACTUAL",{"date":129,"type":114},"2026-08-01",{"date":131,"type":114},"2031-12",{"name":5,"class":6}]