[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634240":3},{"organization":4,"outcomesModule":7,"designInfo":39,"detailedDescription":46,"studyPopulation":42,"armGroups":47,"interventions":56,"overallOfficials":70,"centralContacts":74,"locations":42,"responsibleParty":82,"collaborators":42,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":42,"eligibilityCriteria":90,"healthyVolunteers":86,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":42,"studyType":97,"phases":98,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":106,"whyStopped":42,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":42},{"fullName":5,"class":6},"Boston University Charles River Campus","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":26},[9,13],{"measure":10,"description":11,"timeFrame":12},"Exercise-Induced Hypoalgesia (EIH)","Change in pressure pain threshold (PPT) from baseline to after each walking task","Baseline",{"measure":14,"description":15,"timeFrame":12},"medial quadriceps - medial hamstrings muscle coactivation","Medial quadriceps-medial hamstrings muscle co-activation in each walking task will be assessed using surface electromyography",[17,20,23],{"measure":18,"description":19,"timeFrame":12},"Medial quadriceps- medial gastrocnemius muscle coactivation","Medial quadriceps-medial gastrocnemius muscle co-activation in each walking task will be assessed using surface electromyography",{"measure":21,"description":22,"timeFrame":12},"lateral quadriceps- lateral hamstrings muscle coactivation","Lateral quadriceps-lateral hamstrings muscle co-activation in each walking task will be assessed using surface electromyography",{"measure":24,"description":25,"timeFrame":12},"lateral quadriceps - lateral gastrocnemius muscle coactivation","Lateral quadriceps-lateral gastrocnemoius muscle co-activation in each walking task will be assessed using surface electromyography",[27,30,33,36],{"measure":28,"description":29,"timeFrame":12},"Prefrontal cortex activation","Prefrontal cortex (PFC) brain activation during each walking task will be assessed using functional near-infrared spectroscopy (fNIRS)",{"measure":31,"description":32,"timeFrame":12},"Supplementary Motor Area activation","Supplementary Motor Area (SMA) brain activation during each walking task will be assessed using functional near-infrared spectroscopy (fNIRS)",{"measure":34,"description":35,"timeFrame":12},"Auditory-motor synchronization","difference between actual cadence and target cadence in each walking ask (except walking to no music or metronome)",{"measure":37,"description":38,"timeFrame":12},"physical activity enjoyment","Modified Physical Activity Enjoyment Scale (PACES) score after each walking task. Range is 7-49 with higher scores indicating greater enjoyment.",{"allocation":40,"interventionModel":41,"interventionModelDescription":42,"primaryPurpose":43,"observationalModel":42,"timePerspective":42,"maskingInfo":44},"NA","SINGLE_GROUP",null,"BASIC_SCIENCE",{"masking":45,"maskingDescription":42,"whoMasked":42},"NONE","Participants with knee osteoarthritis (OA) will complete a single study visit which will include three walking tasks, each being 25 minutes in duration. The walking tasks will include walking without music or metronome, walking to metronome, and walking with music. Participants muscle activity, brain activity, and movements will be recorded during these tasks. Participant's pressure pain threshold will be recorded at the beginning and after each task.",[48],{"label":49,"type":50,"description":51,"interventionNames":52},"Rhythmic auditory stimulation during walking","EXPERIMENTAL","All participants will be exposed to different walking conditions including music, metronome, and no music or metronome",[53,54,55],"Behavioral: Rhythmic Auditory Stimulation with music","Behavioral: Rhythmic Auditory Stimulation with metronome","Behavioral: Control",[57,62,66],{"type":58,"name":59,"description":60,"armGroupLabels":61,"otherNames":42},"BEHAVIORAL","Rhythmic Auditory Stimulation with music","Walking to rhythmic Auditory Stimulation with music",[49],{"type":58,"name":63,"description":64,"armGroupLabels":65,"otherNames":42},"Rhythmic Auditory Stimulation with metronome","walking to rhythmic Auditory Stimulation with metronome",[49],{"type":58,"name":67,"description":68,"armGroupLabels":69,"otherNames":42},"Control","Walking to no music or metronome",[49],[71],{"name":72,"affiliation":5,"role":73},"Deepak Kumar, PT, PhD","PRINCIPAL_INVESTIGATOR",[75,79],{"name":72,"role":76,"phone":77,"phoneExt":42,"email":78},"CONTACT","617-358-3037","kumard@bu.edu",{"name":80,"role":76,"phone":42,"phoneExt":42,"email":81},"Yiwen Yang, DPT","ywyang@bu.edu",{"type":83,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100634240","effects-of-music-during-walking-on-pain-and-muscle-activation-in-people-with-chronic-pain-due-to-knee-osteoarthritis-100634240",false,"NCT07537114","Effects of Music During Walking on Pain and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis","Effects of Music-Based Rhythmic Auditory Stimulation During Walking on Nociceptive Signaling and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis","Inclusion Criteria:\n\n* Have activity related pain\n* Experience morning knee stiffness ≤ 30 minutes\n* Knee pain on most days for 3 months or more\n* Able to walk at least 20 minutes with assistance\n* Average overall knee pain severity of ≥= 4 on a 11-point numeric rating scale during previous week\n* BMI ≤ 40\n* Able to communicate using English at a level to understand the study procedures and informed consent\n\nExclusion Criteria:\n\n* Contraindications to exercise\n* Joint replacement in either hip, knee, or ankle\n* History of other disease that may involve the index joint including inflammatory joint disease such as rheumatoid arthritis, seronegative spondyloarthropathy (eg, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease related arthropathy), crystalline disease (eg, gout or pseudogout), lupus erythematosus, knee joint infections, Paget's disease affecting the knee, or knee joint tumors.\n* Previous knee osteotomy in either knee\n* Other health conditions that impact motor functioning or prevent participation (e.g., stroke, Parkinson's disease, Alzheimer's disease, Multiple Sclerosis, diabetic neuropathy, etc.)\n* Corticosteroid or hyaluronic acid injections in either knee in the previous 3 months\n* Pregnancy (self-report)\n* Suspected or known drugs or alcohol abuse\n* Mini-mental State Examination (MMSE) score \\\u003C 24\n* Hearing impairments\n* Pain in lower back or legs that is greater than knee pain","ALL","50 Years","85 Years",{"count":95,"type":96},20,"ESTIMATED","INTERVENTIONAL",[40],"The purpose of this research study is to compare muscle activation, changes in pain sensitivity, and brain function, between different walking conditions, including walking to music, walking to metronome, and walking without music or metronome.",[101],"Knee Osteoarthritis",[103,104,105],"music","rhythmic auditory stimulation","knee pain","NOT_YET_RECRUITING","2026-08-26",{"date":109,"type":110},"2026-08-28","ACTUAL",{"date":112,"type":96},"2026-11",{"date":114,"type":96},"2027-07",{"name":5,"class":6}]