[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647585":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":43,"centralContacts":43,"locations":52,"responsibleParty":72,"collaborators":43,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":43,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":43,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":99,"overallStatus":106,"whyStopped":43,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Mahidol University","OTHER",[8,15,19,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Policosanol Plus Exercise Training","EXPERIMENTAL","Participants in this arm will receive policosanol supplementation at a dose of 5 mg per day for 12 weeks and will participate in a standardized concurrent exercise training program combining aerobic and resistance exercise (3 days per week).",[13,14],"Dietary Supplement: Policosanol","Behavioral: Concurrent Exercise Training",{"label":16,"type":10,"description":17,"interventionNames":18},"Policosanol Alone","Participants in this arm will receive policosanol supplementation at a dose of 5 mg per day for 12 weeks and will not participate in the structured exercise training program.",[13],{"label":20,"type":21,"description":22,"interventionNames":23},"Placebo Plus Exercise Training","ACTIVE_COMPARATOR","Participants in this arm will receive a matching placebo for 12 weeks and will participate in a standardized concurrent exercise training program combining aerobic and resistance exercise (3 days per week).",[24,14],"Dietary Supplement: Placebo",{"label":26,"type":27,"description":28,"interventionNames":29},"Placebo Alone","PLACEBO_COMPARATOR","Participants in this arm will receive a matching placebo for 12 weeks and will not participate in the structured exercise training program.",[24],[31,39,44],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DIETARY_SUPPLEMENT","Policosanol","Participants assigned to the policosanol intervention will receive policosanol supplementation at a dose of 5 mg per day for 12 weeks. The supplement will be administered orally. This intervention is intended to evaluate the effect of low-dose policosanol on physical fitness, muscle recovery, inflammatory markers, and blood lipid profiles in adults with dyslipidemia.",[16,9],[37,38],"Octacosanol","Sugarcane-derived policosanol",{"type":32,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"Placebo","Participants assigned to the placebo intervention will receive a matching placebo product for 12 weeks. The placebo will be prepared to resemble the policosanol supplement in appearance and will be administered in the same manner. This intervention will serve as the control for policosanol supplementation.",[26,20],null,{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":49},"BEHAVIORAL","Concurrent Exercise Training","Participants assigned to the exercise intervention will complete a standardized concurrent exercise training program for 12 weeks. The program will combine aerobic and resistance exercise components and will be performed 3 days per week, approximately 60 minutes per session. This intervention is intended to evaluate the effect of structured exercise training, alone or combined with policosanol supplementation, on physical fitness, muscle recovery, inflammatory markers, and blood lipid profiles.",[20,9],[50,51],"Combined aerobic and resistance exercise training","Exercise training",[53],{"facility":54,"status":43,"city":55,"state":43,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Institute of Nutrition, Mahidol University","Nakhon Pathom","73170","Thailand","TH",{"type":60,"coordinates":61},"Point",[62,63],100.04427,13.8196,{"lat":63,"lon":62},[66],{"name":67,"role":68,"phone":69,"phoneExt":70,"email":71},"Songdhasn Chinapong, Ph.D.","CONTACT","+66 2 800 2380","435","Songdhasn.chi@mahidol.ac.th",{"type":73,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"PRINCIPAL_INVESTIGATOR","Songdhasn Chinapong","Lecturer","100647585","effects-of-policosanol-and-exercise-on-fitness-and-lipids-in-people-with-elevated-blood-lipids-100647585",false,"NCT07710261","Effects of Policosanol and Exercise on Fitness and Lipids in People With Elevated Blood Lipids","Effect of Policosanol Supplementation Combined With Concurrent Exercise Training on Physical Fitness and Lipid Profiles in Healthy Volunteers With Elevated Blood Lipid But Not Required Medical Treatment","Inclusion Criteria:\n\n* Men and women aged 25 to 59 years.\n* BMI between 18.5 and 29.9 kg\u002Fm².\n* Diagnosed with or presenting with dyslipidemia within the past 3 months, based on laboratory assessment at baseline or a standard laboratory report issued within the past 3 months, according to the National Cholesterol Education Program Adult Treatment Panel III criteria, defined by at least one of the following:\n* Total cholesterol ≥ 200 mg\u002FdL;\n* Low-density lipoprotein cholesterol ≥ 130 mg\u002FdL and \\\u003C 190 mg\u002FdL;\n* High-density lipoprotein cholesterol \\\u003C 40 mg\u002FdL in men;\n* High-density lipoprotein cholesterol \\\u003C 50 mg\u002FdL in women;\n* Triglycerides ≥ 150 mg\u002FdL.\n* Free from chronic or comorbid conditions that contraindicate participation in aerobic or resistance exercise.\n* Cleared for physical activity based on the Physical Activity Readiness Questionnaire for Everyone.\n* Not regularly physically active during the preceding 3 months, defined as fewer than 3 exercise sessions per week or less than 150 minutes of exercise per week.\n* Able and willing to participate in the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Current or recent use within the past 3 months of lipid-lowering medications or dietary supplements known to influence lipid metabolism, including statins, fibrates, niacin, omega-3 fatty acids, red yeast rice, or policosanol.\n* Known allergy or hypersensitivity to policosanol, sugarcane derivatives, capsule components, or any excipients in the supplement formulation.\n* Presence of chronic or comorbid conditions that may make exercise participation unsafe, including but not limited to cardiovascular disease, chronic obstructive pulmonary disease, severe arthritis, osteoporosis, uncontrolled diabetes, gastrointestinal disorders, or neurological impairments affecting movement control.\n* High-risk lifestyle factors, including heavy smoking, excessive alcohol consumption, or use of recreational drugs.\n\nInability to comply with the study protocol, including inability to participate in the exercise program when assigned or inability to attend scheduled follow-up assessments.\n\n\\- Refusal or inability to provide written informed consent independently.","ALL","25 Years","59 Years",{"count":87,"type":88},120,"ESTIMATED","INTERVENTIONAL",[91],"NA","This study will evaluate the effects of policosanol supplementation, concurrent exercise training, and their combination on physical fitness, muscle recovery, inflammatory markers, and blood lipid profiles in adults with elevated blood lipids who are not currently indicated for lipid-lowering medication.\n\nParticipants will be randomly assigned to one of four groups for 12 weeks: policosanol plus exercise training, policosanol alone, placebo plus exercise training, or placebo without structured exercise training. Participants assigned to the supplementation groups will take policosanol 5 mg per day, while those assigned to the placebo groups will take a matching placebo. Participants assigned to the exercise groups will complete a standardized concurrent exercise training program combining aerobic and resistance exercise.\n\nThe study will compare changes in physical fitness, lipid profiles, and selected blood biomarkers before and after the intervention. The findings may help determine whether low-dose policosanol, alone or combined with exercise training, can support cardiometabolic health and physical fitness in adults with dyslipidemia.",[94,95,96,97,98],"Dyslipidemia","Elevated Blood Lipids","Physical Fitness","Exercise Training","Muscle Function, Handgrip Strength Test",[33,37,100,46,101,102,103,104,96,94,105],"Dietary Supplement","Aerobic Exercise","Resistance Exercise","Blood Lipid Profile","Muscle Function","Nutraceutical","NOT_YET_RECRUITING","2026-07-15",{"date":109,"type":110},"2026-07-17","ACTUAL",{"date":112,"type":88},"2026-06-22",{"date":114,"type":88},"2027-01-29",{"name":5,"class":6},1]