[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100512828":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":35,"locations":42,"responsibleParty":59,"collaborators":22,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":22,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":45,"whyStopped":22,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"First Affiliated Hospital Xi'an Jiaotong University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A (high-frequency group )","EXPERIMENTAL","Subjects aged 18 to 45 years and in good health agree to participate in the clinical trial and sign an informed consent form. The high-frequency remote ischemic preconditioning (RIPC) group will undergo RIPC training continuously for seven days, twice daily, with each session consisting of four cycles of 5 minutes of ischemia followed by 5 minutes of reperfusion.",[13],"Device: Remote ischaemic preconditioning",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B (low-frequency group )","Subjects aged 18 to 45 years and in good health agree to participate in the clinical trial and sign an informed consent form. The low-frequency RIPC group will follow the same cycle and compression pattern but will train only once a day.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"no-intervention control group","NO_INTERVENTION","Participants in the no-intervention control group will not receive RIPC training or any other study-related intervention. They will undergo blood collection at the corresponding time points: baseline, Day 7, and Day 14.",null,[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":22},"DEVICE","Remote ischaemic preconditioning","The participants rested in the supine position for 5 minutes, then turn on the ischaemic preconditioning apparatus and place the automatically programmed blood pressure cuff on both upper arms of the participant, pressurize to 200 mmHg, pressurize for 5 minutes, rest for 5 minutes, perform 4 cycles for a total of 40 minutes each time. The training for participants in group A will be performed once daily, while for participants in group B the training will be performed twice daily. And heart rate and blood pressure before and after each training will be recorded for 7 days.",[9,15],[30,33],{"name":31,"affiliation":5,"role":32},"Guoliang Li","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":5,"role":32},"Yang Yan",[36,40],{"name":31,"role":37,"phone":38,"phoneExt":22,"email":39},"CONTACT","00-86-029-85323805","liguoliang_med@163.com",{"name":34,"role":37,"phone":22,"phoneExt":22,"email":41},"yangyan3@mail.xjtu.edu.cn",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"First Affiliated Hospital of Xian Jiantong University","RECRUITING","Xi'an","Shaanxi","710061","China","CN",{"type":52,"coordinates":53},"Point",[54,55],108.92861,34.25833,{"lat":55,"lon":54},[58],{"name":31,"role":37,"phone":22,"phoneExt":22,"email":39},{"type":60,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100512828","effects-of-remote-ischemic-preconditioning-on-peripheral-blood-biomarkers-in-healthy-adults-eminent-100512828",false,"NCT05957523","Effects of Remote Ischemic Preconditioning on Peripheral Blood Biomarkers in Healthy Adults (EMINENT)","Effects of Remote Ischemic Preconditioning on Peripheral Blood Biomarkers in Healthy Adults (EMINENT): a Single-centre, Open-label, Randomized Controlled Clinical Trial","EMINENT","Inclusion Criteria:\n\n* Aged 18 to 45 years;\n* Be in good health;\n* Consent to participate in the clinical trial and sign the informed consent form.\n\nExclusion Criteria:\n\n* Abnormal results in biochemical checks and physiological indicators.\n* Cardiovascular and cerebrovascular diseases: hypertension, coronary heart disease, congenital heart disease, cerebrovascular alterations, etc.\n* Endocrine diseases: diabetes, thyroid disorders, etc.\n* Hematologic diseases: anemia, paroxysmal hemoglobinuria, primary thrombocytosis, etc.\n* Infectious diseases: hepatitis B, hepatitis C, syphilis, etc.\n* Cancer.\n* Neurological and psychiatric disorders.\n* Vascular diseases: peripheral vascular disease, Raynaud's syndrome, thromboembolic diseases.\n* Major trauma or surgery within the last six months.\n* Pregnant or breastfeeding women.\n* Upper limbs unsuitable for compression treatment: history of upper limb surgery, presence of tissue damage and limb deformity, and concomitant hemorrhagic diseases.\n* Recent circumstances that may affect results: blood donors within the last month, any medication taken within the last month, fever within the last week, women within their menstrual cycle or within 7 days before the start of menstruation.\n* Patients who refuse to sign the informed consent form for participation in this study.",true,"ALL","18 Years","45 Years",{"count":74,"type":75},80,"ESTIMATED","INTERVENTIONAL",[78],"NA","The aim of this study is to investigate the effects of remote ischaemic preconditioning on the peripheral blood characteristics of healthy adults and to explore the possible mechanisms for improving ischaemia\u002Freperfusion injury and its protective effects on the cardiovascular system.",[81],"Ischemic Preconditioning",[83,84,85],"Remote ischemic preconditioning","Peripheral blood","Healthy adults","2026-07-20",{"date":88,"type":89},"2026-07-21","ACTUAL",{"date":91,"type":89},"2024-06-27",{"date":93,"type":75},"2026-10-31",{"name":5,"class":6},1]