[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652079":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":35,"locations":41,"responsibleParty":65,"collaborators":30,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":30,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":30,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":91,"whyStopped":30,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Kutahya Health Sciences University","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"taVNS Before Exercise","EXPERIMENTAL","Participants will receive transcutaneous auricular vagus nerve stimulation before performing the standardized exercise program.",[13,14],"Device: Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)","Other: Exercise Program",{"label":16,"type":10,"description":17,"interventionNames":18},"taVNS After Exercise","Participants will first perform the standardized exercise program and will subsequently receive transcutaneous auricular vagus nerve stimulation.",[13,14],{"label":20,"type":21,"description":22,"interventionNames":23},"Exercise only","ACTIVE_COMPARATOR","Participants will receive the standardized exercise program without transcutaneous auricular vagus nerve stimulation.",[14],[25,31],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)","Transcutaneous auricular vagus nerve stimulation will be delivered non-invasively through an auricular stimulation device targeting the auricular branch of the vagus nerve. Stimulation will be administered under researcher supervision using standardized stimulation parameters according to the device instructions and study protocol.",[16,9],null,{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Exercise Program","Participants will perform a standardized exercise program for chronic neck pain including postural correction, deep cervical flexor activation, cervical mobility, scapular stabilization, and stretching exercises. Exercises will be performed under researcher supervision during the intervention period.",[20,16,9],[36],{"name":37,"role":38,"phone":39,"phoneExt":30,"email":40},"Batuhan YUKSEL, Msc.","CONTACT","00905334350996","bthanyksel13@gmail.com",[42],{"facility":43,"status":30,"city":44,"state":45,"zip":46,"country":47,"countryCode":30,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Kutahya Health Sciences University Physical Therapy and Rehabilitation Research Center","Kütahya","Türkiye","43100","Turkey (Türkiye)",{"type":49,"coordinates":50},"Point",[51,52],29.98333,39.42417,{"lat":52,"lon":51},[55,60,62],{"name":56,"role":38,"phone":57,"phoneExt":58,"email":59},"Ismail SARACOGLU, PhD","002742651300","1499","ismail.saracoglu@ksbu.edu.tr",{"name":37,"role":61,"phone":30,"phoneExt":30,"email":30},"PRINCIPAL_INVESTIGATOR",{"name":63,"role":64,"phone":30,"phoneExt":30,"email":30},"Merve Akdeniz LEBLEBİCİER, MD","SUB_INVESTIGATOR",{"type":61,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Ismail Saracoglu","PhD","100652079","effects-of-the-timing-of-vagus-nerve-stimulation-combined-with-exercise-in-chronic-neck-pain-100652079",false,"NCT07769034","Effects of the Timing of Vagus Nerve Stimulation Combined With Exercise in Chronic Neck Pain","Does Timing Matter? Effects of Transcutaneous Auricular Vagus Nerve Stimulation Before and After Exercise in Chronic Neck Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of chronic neck pain confirmed by a physical medicine and rehabilitation physician.\n* Age between 18 and 65 years.\n* Neck pain persisting or recurring for at least 3 months.\n* Ability to participate in the exercise program included in the study protocol.\n* No contraindication to transcutaneous auricular vagus nerve stimulation.\n* Willingness to provide written informed consent.\n* Willingness to participate regularly in the planned exercise and assessment sessions.\n\nExclusion Criteria:\n\n* Cervical radiculopathy or specific neurological findings.\n* Previous cervical spine surgery.\n* Serious cardiovascular disease.\n* Serious neurological or systemic disease.\n* Pregnancy.\n* Orthopedic or musculoskeletal conditions preventing participation in exercise.\n* Cognitive or communication problems that prevent completion of the assessment instruments.\n* Inability or unwillingness to comply with the study protocol or attend scheduled sessions.","ALL","18 Years","65 Years",{"count":79,"type":80},81,"ESTIMATED","INTERVENTIONAL",[83],"NA","This randomized controlled trial aims to investigate whether the timing of transcutaneous auricular vagus nerve stimulation (taVNS) relative to exercise influences clinical and autonomic outcomes in individuals with chronic neck pain.\n\nParticipants will be randomly allocated to one of three groups: taVNS applied before exercise, taVNS applied after exercise, or exercise alone. All groups will receive a standardized exercise program designed for chronic neck pain. The intervention will be conducted over a 6- to 8-week period.\n\nThe effects of the interventions will be evaluated using pain intensity, neck-related disability, sleep quality, heart rate variability, and exercise adherence. The study will determine whether applying taVNS before or after exercise provides additional benefits compared with exercise alone and whether the timing of stimulation influences treatment outcomes.",[86],"Chronic Neck Pain",[88,89,90],"CHRONIC PAIN","VAGAL NERVE STIMULATION","EXERCISE","NOT_YET_RECRUITING","2026-08-12",{"date":94,"type":95},"2026-08-17","ACTUAL",{"date":97,"type":80},"2026-09-14",{"date":99,"type":80},"2027-09-15",{"name":5,"class":6},1]