[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645730":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":30,"responsibleParty":46,"collaborators":18,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":18,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":18,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":33,"whyStopped":18,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"The First Affiliated Hospital of Anhui Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"tDCS group","EXPERIMENTAL","PSA patients enrolled in the tDCS group received tDCS treatment twice daily for 7 consecutive days, along with 7 days of speech-language therapy. The current intensity was 2 mA, and each treatment session lasted 20 minutes.",[13],"Other: transcranial direct current stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"The speech-language therapy group","NO_INTERVENTION","The speech-language therapy group received only 7 days of speech-language therapy.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"transcranial direct current stimulation","As a non-invasive brain stimulation technique, tDCS offers advantages such as convenience, safety, and low cost. Its mechanism of action involves regulating neuronal activity in the brain by applying a weak direct current to the scalp.",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Jian Guan","CONTACT","+86-19810696998","1003935828@qq.com",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":18,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"transcranial direct current stimulation (tDCS)","RECRUITING","Hefei","Anhui","China","CN",{"type":39,"coordinates":40},"Point",[41,42],117.28083,31.86389,{"lat":42,"lon":41},[45],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Panpan Hu, MD","Head of Neurology Department, The First Affiliated Hospital of Anhui Medical University","100645730","efficacy-and-neural-mechanisms-of-transcranial-direct-current-stimulation-targeting-the-supplementary-motor-area-for-the-treatment-of-subacute-post-stroke-aphasia-100645730",false,"NCT07700537","Efficacy and Neural Mechanisms of Transcranial Direct Current Stimulation Targeting the Supplementary Motor Area for the Treatment of Subacute Post-stroke Aphasia","Study on the Efficacy and Neural Mechanisms of Transcranial Direct Current Stimulation Targeting the Supplementary Motor Area for the Treatment of Subacute Post-stroke Aphasia","Inclusion Criteria:\n\n* Patients must be between 18 and 80 years of age\n* First stroke in the left hemisphere\n* Stroke onset within the past 12 weeks\n* Native Chinese speakers who were able to communicate normally prior to onset\n* Diagnosed with aphasia using the ABC scale\n* Right-handed\n* Informed consent obtained from the patient and family members\n\nExclusion Criteria:\n\n* Time since stroke onset exceeds 12 weeks\n* History of psychiatric or neurological disorders\n* History of surgery for severe head trauma, brain tumors, or brain abscesses\n* Severe articulation disorders\n* Claustrophobia or implants incompatible with MRI\n* Inability to cooperate with language scale testing or fMRI scanning\n* History of previous stroke","ALL","18 Years","80 Years",{"count":61,"type":62},40,"ESTIMATED","INTERVENTIONAL",[65],"NA","This study aims to investigate the efficacy of transcranial direct current stimulation (tDCS) in patients with post-stroke aphasia (PSA) and to explore its potential neural mechanisms. The study will recruit PSA patients and provide them with 14 tDCS sessions over 7 days, along with speech therapy. Language Behavior Scale scores and resting-state functional MRI scans will be collected before and after the intervention. In addition, a retrospective comparison will be conducted of language function and resting-state fMRI changes in a group of PSA patients who received only speech therapy; these patients did not undergo any physical intervention but received only speech therapy. Changes in Language Behavior Scale scores and functional connectivity (FC) before and after treatment in the speech therapy-only group will be analyzed and compared with those in the tDCS intervention group.",[68],"Post-stroke Aphasia",[70,71,21],"post-stroke aphasia","supplementary motor area","2026-07-15",{"date":74,"type":75},"2026-07-17","ACTUAL",{"date":77,"type":75},"2025-07-30",{"date":79,"type":62},"2027-01-31",{"name":5,"class":6},1]