[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652330":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":36,"centralContacts":47,"locations":54,"responsibleParty":69,"collaborators":26,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":26,"eligibilityCriteria":78,"healthyVolunteers":75,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":26,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":26,"overallStatus":91,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Cairo University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"AI-Guided Physical Therapy Program + Lifestyle modification and joint protection strategies","EXPERIMENTAL","Participants in this arm will receive an individualized AI-guided physical therapy program generated using ChatGPT-4. The researcher will manually enter standardized patient data, including age, sex, pain intensity (VAS), functional disability (WOMAC), knee range of motion, symptom duration, and physical activity level. ChatGPT-4 will then generate an evidence-based, in-clinic rehabilitation program for knee osteoarthritis. Participants will also receive education on lifestyle modification and joint protection strategies.",[13,14],"Other: AI-Guided Physical Therapy Program","Behavioral: Lifestyle Modification and Joint Protection Education",{"label":16,"type":17,"description":18,"interventionNames":19},"Traditional Physical Therapy Program + Lifestyle modification and joint protection strategies","ACTIVE_COMPARATOR","Participants in this arm will receive a conventional physical therapy program consisting of transcutaneous electrical nerve stimulation (TENS), strengthening exercises, flexibility exercises, and balance exercises. The program will be delivered three times per week for 12 weeks. Participants will also receive education on lifestyle modification and joint protection strategies.",[20,14],"Other: Traditional Physical Therapy Program",[22,27,31],{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"AI-Guided Physical Therapy Program","Participants will receive an individualized physical therapy program generated using ChatGPT-4. The researcher will manually enter standardized patient data, including age, sex, pain intensity (VAS), functional disability (WOMAC), knee range of motion, symptom duration, and physical activity level. ChatGPT-4 will be prompted to generate an evidence-based, in-clinic rehabilitation program for adults with knee osteoarthritis.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Traditional Physical Therapy Program","Participants will receive a traditional physical therapy program including transcutaneous electrical nerve stimulation (TENS), strengthening exercises, flexibility exercises, and balance exercises. The intervention will be administered three sessions per week for 12 weeks.",[16],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":26},"BEHAVIORAL","Lifestyle Modification and Joint Protection Education","Participants in both study arms will receive education on lifestyle modification and joint protection strategies as part of the management of knee osteoarthritis.",[9,16],[37,41,45],{"name":38,"affiliation":39,"role":40},"Mohsen El Sayyed, PhD","Professor, Cairo University","STUDY_CHAIR",{"name":42,"affiliation":43,"role":44},"Rania Reda Mohamed, PhD","Assistant Professor, Cairo University","STUDY_DIRECTOR",{"name":46,"affiliation":39,"role":44},"Ali Al- Zawahri, PhD",[48,53],{"name":49,"role":50,"phone":51,"phoneExt":26,"email":52},"Marina Hosny Raghep, B.Sc","CONTACT","+20 12 71739917","Marinahosny2895@gmail.com",{"name":42,"role":50,"phone":26,"phoneExt":26,"email":26},[55],{"facility":56,"status":26,"city":57,"state":26,"zip":26,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Faculty of physical therapy, Cairo University","Giza","Egypt","EG",{"type":61,"coordinates":62},"Point",[63,64],31.20861,30.00944,{"lat":64,"lon":63},[67,68],{"name":49,"role":50,"phone":51,"phoneExt":26,"email":52},{"name":42,"role":50,"phone":26,"phoneExt":26,"email":26},{"type":70,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Marina Hosny Raghep","Principal Investigator","100652330","efficacy-of-ai-driven-and-traditional-physical-therapy-programs-in-patients-with-knee-osteoarthritis-100652330",false,"NCT07774195","Efficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Participants will be recruited through outpatient orthopedic clinics and community health centers affiliated with the study sites.\n* Their age will be ranged from 45-70 years.\n* Their body mass index (BMI) will be ranged from 24.9 to 30 kg \u002Fm2 .\n* With a clinical and radiographic diagnosis of knee osteoarthritis based on American College of Rheumatology criteria, with Kellgren-Lawrence grade II or III osteoarthritis, and who will able to ambulate\n* Independently walk without assistive devices.\n\nExclusion Criteria:\n\n* Prior knee replacement surgery, inflammatory arthritis (e.g., rheumatoid arthritis).\n* Recent intra-articular steroid injections within three months.\n* Neurologic impairments affecting lower limb function.\n* Inability to comprehend or use the mobile application due to cognitive or sensory impairments.","ALL","45 Years","70 Years",{"count":83,"type":84},40,"ESTIMATED","INTERVENTIONAL",[87],"NA","This study aims to compare the effectiveness of an artificial intelligence (AI)-guided physical therapy program with a traditional physical therapy program in patients with knee osteoarthritis.\n\nForty patients with knee osteoarthritis will be randomly assigned to one of two groups. The traditional physical therapy group will receive a conventional rehabilitation program including transcutaneous electrical nerve stimulation (TENS), strengthening, flexibility, and balance exercises. The AI-guided group will receive an individualized rehabilitation program generated using ChatGPT-4 based on standardized patient information and clinical assessment findings.\n\nBoth groups will receive education regarding lifestyle modification and joint protection strategies. The effects of the two rehabilitation approaches will be evaluated by measuring pain intensity, knee range of motion, knee-related functional ability, and functional mobility and fall risk before and after the intervention.\n\nThe study will determine whether an AI-guided physical therapy program can provide outcomes comparable or superior to those of traditional physical therapy in individuals with knee osteoarthritis.",[90],"Knee Osteoarthritis","NOT_YET_RECRUITING","2026-08-14",{"date":94,"type":95},"2026-08-19","ACTUAL",{"date":97,"type":84},"2026-08-21",{"date":99,"type":84},"2026-11-30",{"name":5,"class":6},1]