[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651706":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":36,"centralContacts":37,"locations":43,"responsibleParty":60,"collaborators":36,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":36,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":36,"enrollmentInfo":73,"targetDuration":36,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":46,"whyStopped":36,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Medicine and Pharmacy at Ho Chi Minh City","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"A-PRF+ and Xenograft","EXPERIMENTAL","Open flap debridement followed by the application of A-PRF+ mixed with xenograft (Cerabone), covered by an A-PRF+ membrane",[13],"Procedure: A-PRF+ and Xenograft",{"label":15,"type":16,"description":17,"interventionNames":18},"Collagen Membrane and Xenograft","ACTIVE_COMPARATOR","Open flap debridement followed by the application of xenograft (Cerabone) covered by a resorbable collagen membrane",[19],"Procedure: Collagen Membrane and Xenograft",[21,29],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Open flap debridement surgery. The furcation defect is filled with a mixture of A-PRF+ fragments and bovine xenograft (Cerabone), and then covered with an A-PRF+ membrane before suturing",[9],[26,27,28],"Advanced Platelet-Rich Fibrin plus","Cerabone","A-PRF+",{"type":22,"name":15,"description":30,"armGroupLabels":31,"otherNames":32},"Open flap debridement surgery. The furcation defect is filled with bovine xenograft (Cerabone) and covered with a resorbable collagen membrane before suturing",[15],[33,34,27,35],"Guided Tissue Regeneration","Bio-Gide","Collagen membrane",null,[38],{"name":39,"role":40,"phone":41,"phoneExt":36,"email":42},"Thanh Si Ho, Doctor of Dental Surgery","CONTACT","+84944510521","sithanhlk2000@gmail.com",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Faculty of Dentistry, University of Medicine and Pharmacy at Ho Chi Minh City","RECRUITING","Ho Chi Minh City","Ho Chi Minh City (HCMC)","700000","Vietnam","VN",{"type":53,"coordinates":54},"Point",[55,56],106.62965,10.82302,{"lat":56,"lon":55},[59],{"name":39,"role":40,"phone":41,"phoneExt":36,"email":42},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"PRINCIPAL_INVESTIGATOR","Thanh Si Ho","Doctor of Dental Surgery","100651706","efficacy-of-prf-and-xenograft-in-treating-mandibular-molar-furcation-involvements-100651706",false,"NCT07764029","Efficacy of PRF and Xenograft in Treating Mandibular Molar Furcation Involvements","Efficacy of Platelet-Rich Fibrin Combined With Xenograft in the Treatment of Mandibular Molar Furcation Involvements","Inclusion Criteria:\n\n* Patients over 18 years old\n* Patients diagnosed with periodontitis who have completed non-surgical treatment: scaling and root planing\n* Patients attending a follow-up visit at least 5 weeks after non-surgical treatment, demonstrating compliance and good oral hygiene cooperation\n* Presence of a mandibular molar with a Degree II furcation involvement according to Hamp (1975), presenting a residual periodontal pocket at the buccal site (PPD ≥ 5mm) after non-surgical treatment, and showing radiolucency in the furcation area on CBCT imaging\n* Plaque Index (PlI) \\\u003C 1 following non-surgical treatment\n* Width of keratinized gingiva ≥ 2mm\n* Teeth with furcation defects where gingival recession does not extend apically beyond the buccal furcation fornix (no supragingival furcation exposure)\n* Teeth without occlusal trauma, pulpal or periapical pathologies, and no combined periodontic-endodontic lesions\n* Degree II furcation involvement according to Hamp (1975) and Subclass A or B according to Tarnow and Fletcher (1984)\n* The defect is located apical to the interproximal alveolar bone crest on CBCT imaging\n\nExclusion Criteria:\n\n* Patients with systemic diseases affecting periodontal treatment outcomes, such as: diabetes mellitus, heart disease requiring anticoagulant therapy, blood disorders, immunodeficiency, etc\n* Pregnant or lactating patients\n* Patients who have used antibiotics or any other medications affecting periodontal treatment outcomes within the last 6 months\n* Patients who smoke tobacco.\n* Patients who have used aspirin or medications affecting blood coagulation within 2 weeks prior to the blood collection for PRF preparation\n* Patients with a history of allergy to local anesthetics\n* Defects associated with grade II tooth mobility that has not been splinted, or grade III tooth mobility according to Miller (2014)","ALL","18 Years",{"count":74,"type":75},22,"ESTIMATED","INTERVENTIONAL",[78],"NA","The purpose of this randomized controlled clinical trial is to compare the effectiveness of advanced platelet-rich fibrin (A-PRF+) combined with xenograft versus a collagen membrane combined with xenograft in the treatment of degree II furcation involvements in mandibular first molars. Adult patients with periodontitis will randomly receive either the A-PRF+ treatment or the collagen membrane treatment during periodontal flap surgery. The study will evaluate clinical periodontal healing, bone regeneration using 3D imaging (CBCT), patient comfort (pain levels and satisfaction), and changes in the TWEAK biomarker in gingival crevicular fluid over a 6-month period.",[81,82],"Periodontitis","Furcation Defects",[84,28,85,86,33,87,88,89],"A-PRF plus","Xenograft","Mandibular Molar","TWEAK","biomarker","collagen membrane","2026-08-12",{"date":92,"type":93},"2026-08-14","ACTUAL",{"date":95,"type":93},"2026-06-25",{"date":97,"type":75},"2027-06-30",{"name":5,"class":6},1]