[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651184":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":38,"locations":48,"responsibleParty":63,"collaborators":26,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":26,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":89,"whyStopped":26,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A TIP urethroplasty with autologous PRF","EXPERIMENTAL","Undergoes TIP urethroplasty with intraoperative placement of autologous PRF onto the urethral plate.",[13],"Procedure: Tubularized Incised Plate urethroplasty with intraoperative placement of autologous PRF onto the urethral plate.",{"label":15,"type":16,"description":17,"interventionNames":18},"Group B standard TIP urethroplasty without PRF","ACTIVE_COMPARATOR","Undergoes standard TIP urethroplasty without PRF application",[19],"Procedure: standard Tubularized Incised Plate urethroplasty",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Tubularized Incised Plate urethroplasty with intraoperative placement of autologous PRF onto the urethral plate.","Urethral plate incision and tubularization over a 6-8 Fr stent using absorbable sutures.\n\nApplication of PRF where 8-10 mL of autologous blood is drawn into plain (non-anticoagulant) tubes and a thin PRF membrane is extracted which is fixed on top of the suture line as a first layer and under the incision line as a second layer and secured using a few resorbable polyglyconate 6\u002F0 interrupted sutures.\n\nGlansplasty and skin closure using standard techniques and fixing catheter and dressing",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"standard Tubularized Incised Plate urethroplasty","Urethral plate incision and tubularization over a 6-8 Fr stent using absorbable sutures.\n\nGlansplasty and skin closure using standard techniques and fixing catheter and dressing",[15],[32,35],{"name":33,"affiliation":5,"role":34},"Hany H. Gad, Professor","STUDY_CHAIR",{"name":36,"affiliation":5,"role":37},"Hossam M.H. ElAwady, Professor","STUDY_DIRECTOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":26,"email":43},"Mahmoud Mohamed Magdy El-Ansary, MSc","CONTACT","+201114393349","mahmoudmagdy99@hotmail.com",{"name":45,"role":41,"phone":46,"phoneExt":26,"email":47},"Younan R. Samir, M.D.","+201201255511","dr_yona@live.com",[49],{"facility":5,"status":26,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Cairo","Abbasia","11517","Egypt","EG",{"type":56,"coordinates":57},"Point",[58,59],31.24967,30.06263,{"lat":59,"lon":58},[62],{"name":45,"role":41,"phone":46,"phoneExt":26,"email":47},{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Younan Ramsis","Lecturer of urology","100651184","efficacy-of-prf-in-hypospadias-repair-100651184",false,"NCT07757828","Efficacy of PRF in Hypospadias Repair","Evaluating the Efficacy of Platelet-Rich Fibrin (PRF) in Hypospadias Repair: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosed with primary distal or mid-penile hypospadias.\n* Eligible for first-time (primary) surgical repair using the TIP (Tubularized Incised Plate) technique.\n\nExclusion Criteria:\n\n* previous hypospadias surgery.\n* Associated severe chordee requiring staged repair or patient with crippled hypospadias.\n* Children with systemic diseases that may impair wound healing (e.g., diabetes, immunodeficiency, malnutrition).\n* Presence of bleeding or coagulation disorders.\n* Medically Unfit for surgery.","MALE","6 Months","18 Years",{"count":78,"type":79},80,"ESTIMATED","INTERVENTIONAL",[82],"NA","Hypospadias is an anomaly characterized by an ectopic ventral urethral meatus, and an incomplete or hooded prepuce. Its incidence is estimated at 1 in 200-300 live male births, with variations across populations and severity types.\n\nSuccessful hypospadias repair depends largely on optimal tissue healing and robust vascular support around the neourethra. Thus, many adjunctive techniques have been investigated to improve outcomes, including dartos flaps, tunica vaginalis flaps, and various tissue sealants.\n\nIn recent years, attention has turned toward biological augmentation strategies, particularly the use of platelet-rich plasma (PRP) and platelet-rich fibrin as a potential enhancer of wound healing.\n\nPlatelet-rich fibrin (PRF), a second-generation autologous platelet concentrate, has recently emerged as another promising biologic in tissue engineering.\n\nThis study aims to evaluate the effect of PRF application in primary hypospadias repair surgery and determine its effect in improving healing and reduction of postoperative complications.",[85],"Hypospadias",[85,87,88],"PRF","Repair","NOT_YET_RECRUITING","2026-08-10",{"date":92,"type":93},"2026-08-11","ACTUAL",{"date":95,"type":79},"2026-08-01",{"date":97,"type":79},"2027-10-01",{"name":5,"class":6},1]