[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659472":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":13,"armGroups":23,"interventions":34,"overallOfficials":39,"centralContacts":45,"locations":51,"responsibleParty":71,"collaborators":13,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":76,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":13,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":13,"overallStatus":94,"whyStopped":13,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Dow University of Health Sciences","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Postoperative pain intensity measured using a Visual Analog Scale (VAS)","Postoperative pain intensity will be assessed using a 10-cm Visual Analog Scale (VAS), ranging from 0 (no pain) to 10 (worst imaginable pain). Participants will record their pain intensity at 6, 24, and 48 hours and at 3 and 7 days after root canal treatment. VAS pain scores at each time point will be recorded and compared between the calcium silicate-based sealer and calcium hydroxide-based sealer groups.","6,24 and 48 hours and after 3 and 7 days",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":19,"maskingDescription":13,"whoMasked":20},"DOUBLE",[21,22],"PARTICIPANT","OUTCOMES_ASSESSOR",[24,30],{"label":25,"type":26,"description":27,"interventionNames":28},"Experimental :Calcium silicate based sealer","EXPERIMENTAL","Root canal sealer (CSBS)",[29],"Other: Calcium silicate based sealer",{"label":31,"type":26,"description":32,"interventionNames":33},"Calcium hydroxide based sealer","Root canal sealer (CHBS)",[29],[35],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":13},"Calcium silicate based sealer","Root canal sealer used in ENDODONTIC treatment with core material for obturation of root canals",[31,25],[40,43],{"name":41,"affiliation":5,"role":42},"Dr Ayesha Naz Tariq, Postgraduate Trainee- FCPS","PRINCIPAL_INVESTIGATOR",{"name":44,"affiliation":5,"role":42},"Dr Ayesha Tariq, Postgraduate Trainee- FCPS",[46],{"name":47,"role":48,"phone":49,"phoneExt":13,"email":50},"Ayesha Tariq, Recruiting","CONTACT","03350287343","ayesha.tariq157@gmail.com",[52],{"facility":53,"status":13,"city":54,"state":13,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Dr Ayesha Tariq","Karachi","75100","Pakistan","PK",{"type":59,"coordinates":60},"Point",[61,62],67.0104,24.8608,{"lat":62,"lon":61},[65,68],{"name":66,"role":48,"phone":67,"phoneExt":13,"email":50},"Ayesha Tariq, Postgraduate Trainee- FCPS","03361265165",{"name":69,"role":70,"phone":13,"phoneExt":13,"email":13},"Dr Farah Naz, HOD of Operative and Endodonti","SUB_INVESTIGATOR",{"type":42,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"Ayesha Tariq","Resident, Department of Operative Dentistry","100659472","efficiency-of-calcium-hydroxide-and-calcium-silicate-based-sealers-in-maxillary-and-mandibular-molars-on-post-root-canal-pain-100659472",false,"NCT07865429","Efficiency of Calcium Hydroxide and Calcium Silicate-Based Sealers in Maxillary and Mandibular Molars on Post-Root Canal Pain","Effectiveness of Calcium Silicate- and Calcium Hydroxide-Based Sealers on Post-Endodontic Pain","CBSS","Inclusion Criteria:\n\n1. Medically healthy patients\n2. Age: 18 to 45 years\n3. Vital Pulp with moderate to severe pre-operative pain score (VAS score 4-10 on EPT).\n4. Symptomatic apical periodontitis\n5. Mandibular and maxillary molars.\n6. Periapical index (PAI) scores 1-2.\n\nExclusion Criteria:\n\n1. Patients experiencing root resorption\n2. Teeth with incomplete root development\n3. Calcified canals\n4. Severe malocclusion\n5. Pregnant or breastfeeding patients\n6. Patients who have used analgesics or anti-inflammatory medications within the past 24 hours","ALL","18 Years","45 Years",{"count":86,"type":87},96,"ESTIMATED","INTERVENTIONAL",[90],"NA","patients reported at department of Operative dentistry diagnosis section , patients coming to operative department of DIDC-DUHS with the chief complain of moderate to severe pain will be assessed .Complete history of each patient will be obtained along with clinical examination including percussion test, presence of swelling, sinus tract and mobility of tooth. Pulp sensitivity will be assessef. Periapical x-ray will be used to evaluate periapical status PAI score. . Following anesthesia, the tooth will be isolated with a rubber dam to maintain a dry operating field. An access cavity will then be prepared. The presence of bleeding within the pulp chamber will be regarded as an indicator of pulp vitality. The (WL) will be established using patency files . An endodontic motor (eight teeth E-connect) will be programmed for root canal instrumentation. Root canals will be irrigated with sodium hypochlorite (NaOCl). Root canals will be dried using paper points, and will take master cone periapical radiograph before final obturation procedure. For the CSBS group (CERASEAL; Meta Biomed Co., Cheongju, Korea), the sealer will be applied and a single cone will be used for obturation. For the CHBS group (Seal apex), the obturation will be completed via cold lateral condensation. The teeth will be restored with composite (LUNA SDI). Single operator will perform the complete procedure. Analgesic ibuprofen 400 mg (Brufen) will be prescribed to the patient in case of severe pain",[93],"Calcium Silicate Based Sealer (CSBS)","NOT_YET_RECRUITING","2026-10-04",{"date":97,"type":98},"2026-10-08","ACTUAL",{"date":100,"type":87},"2026-10-15",{"date":102,"type":87},"2027-06-01",{"name":5,"class":6},1]