[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648832":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":35,"responsibleParty":56,"collaborators":60,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":11,"enrollmentInfo":76,"targetDuration":11,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":50,"whyStopped":11,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Samsung Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Anatomy-based group","ACTIVE_COMPARATOR",null,[13],"Procedure: Anatomy-based ablation",{"label":15,"type":16,"description":11,"interventionNames":17},"Emphasize map-guided group","EXPERIMENTAL",[18],"Procedure: Emphasize map-guided ablation",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","Anatomy-based ablation","In the empirical anatomy-based ablation strategy group, pulmonary vein isolation (PVI) will be performed using pulsed-field ablation (PFA) with a single-shot multielectrode catheter. For each pulmonary vein, approximately 4-10 pulse applications will be delivered depending on the catheter position, with each application consisting of several seconds of pulse delivery. The catheter will be positioned around the PV ostia, and electrical isolation will be achieved by utilizing various catheter configurations as necessary. The energy settings and application methods for PFA in this study will follow the manufacturer's recommended protocols and established methods from prior clinical studies. Additionally, the creation of supplementary lesion sets is permitted at the operator's discretion.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Emphasize map-guided ablation","In the Emphasize map-guided substrate ablation group, ablation will be performed using a contact force-sensing irrigated radiofrequency (RF) catheter. Following pulmonary vein isolation (PVI), an Emphasize map will be acquired during atrial fibrillation (AF) using the EnSite X mapping system. Based on this map, electrophysiologically significant pathologic substrates will be evaluated, and additional substrate ablation will be performed. Subsequently, electrical cardioversion will be conducted to restore sinus rhythm. If sinus rhythm is not maintained or if AF is re-induced, an additional Emphasize map may be acquired in the right atrium (RA), and RA substrate ablation can be performed if necessary.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Ju Youn Kim, Ph.D","CONTACT","82+ 2-3410-3419","kzzoo921@gmail.com",[36,49],{"facility":5,"status":37,"city":38,"state":38,"zip":39,"country":40,"countryCode":11,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"NOT_YET_RECRUITING","Seoul","06351","South Korea",{"type":42,"coordinates":43},"Point",[44,45],126.9784,37.566,{"lat":45,"lon":44},[48],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},{"facility":5,"status":50,"city":38,"state":38,"zip":39,"country":40,"countryCode":11,"cosmosGeoPoint":51,"geoPoint":53,"contacts":54},"RECRUITING",{"type":42,"coordinates":52},[44,45],{"lat":45,"lon":44},[55],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Ju Youn Kim","Professor",[61,63,65],{"name":62,"class":6},"Asan Medical Center",{"name":64,"class":6},"Keimyung University Dongsan Medical Center",{"name":66,"class":6},"Korea University Anam Hospital","100648832","empirical-anatomy-based-ablation-vs-emphasize-map-guided-substrate-ablation-in-persistent-atrial-fibrillation--compass-af-100648832",false,"NCT07726901","Empirical Anatomy-Based Ablation vs Emphasize Map-Guided Substrate Ablation in Persistent Atrial Fibrillation : (COMPASS-AF)","COMPASS-AF","Inclusion Criteria:\n\n* Adults aged 19 years or older who have voluntarily provided written informed consent to participate in the study\n* Patients diagnosed with persistent atrial fibrillation (AF) who are scheduled to undergo catheter ablation for AF.\n\nExclusion Criteria:\n\n* History of prior catheter ablation or MAZE surgery for atrial fibrillation.\n* Left atrial (LA) diameter exceeding 60 mm.\n* Patients with end-stage renal disease (ESRD).\n* History of prior open-heart surgery.\n* Women who are pregnant, lactating, or of childbearing potential.\n* Heart failure corresponding to New York Heart Association (NYHA) functional class IV.\n* Acute coronary syndrome (ACS) experienced within the past 3 months.\n* Patients with terminal illness and a life expectancy of less than one year.\n* Any other condition that the investigator deems inappropriate for participation in the study.","ALL","19 Years",{"count":77,"type":78},360,"ESTIMATED","INTERVENTIONAL",[81],"NA","This study is aimed to compare the clinical efficacy of two different catheter ablation strategies in patients with persistent atrial fibrillation.\n\nParticipants will be randomized 1:1 into either the Anatomy-based group or the Emphasize map-guided group\n\n* Anatomy-based group : Pulmonary vein isolation (PVI) using pulsed-field ablation (PFA) with a single-shot multielectrode catheter.\n* Emphasize map-guided group : PVI using radiofrequency (RF) ablation followed by additional EnSite X-guided pathologic substrate modification.\n\nParticipants will be followed for 1 year to compare the incidence of any atrial tachyarrhythmia and other clinical parameters between the two groups.",[84],"Atrial Fibrillation (AF)",[86],"Emphasize map","2026-07-21",{"date":89,"type":90},"2026-07-24","ACTUAL",{"date":92,"type":90},"2026-05-19",{"date":94,"type":78},"2030-12-31",{"name":5,"class":6},2]