[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650004":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":33,"locations":12,"responsibleParty":39,"collaborators":42,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":12,"enrollmentInfo":59,"targetDuration":12,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":77,"whyStopped":12,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":12},{"fullName":5,"class":6},"Stanford University","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Control: Standard Mailed Letter Invitation","NO_INTERVENTION","Veterans randomized to the control arm receive the standard mailed letter invitation to the parent VA Cooperative Studies cardiovascular trial, which represents current standard of care for large-scale VA cardiovascular trial outreach.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Experimental: AI-Supported Virtual Outreach","EXPERIMENTAL","Veterans randomized to the intervention arm receive the standard mailed letter invitation enhanced with a QR code and URL linking to a website hosting AI-generated avatar videos. Veterans may select their preferred Veteran avatar speaker from a diverse set of options and self-select content topics of interest. QR codes are deployed for both the screening and treatment components of the parent cardiovascular trial.",[18],"Behavioral: AI-Generated Avatar Videos and Chatbot for Clinical Trial Outreach",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","AI-Generated Avatar Videos and Chatbot for Clinical Trial Outreach","Veterans randomized to the intervention arm will receive the website link where they can select their preferred Veteran avatar speaker from a diverse set of options and self-select content topics of interest. They may watch the self-directed tailored video to guide their decision to participate in the parent trial.",[14],[26],"AI-Supported Patient Engagement Tool",[28,31],{"name":29,"affiliation":5,"role":30},"Celina Yong, MD, MBA, MSc","PRINCIPAL_INVESTIGATOR",{"name":32,"affiliation":5,"role":30},"Paul Heidenreich, MD",[34],{"name":35,"role":36,"phone":37,"phoneExt":12,"email":38},"Nicholas Vesom, MPH, CCRP","CONTACT","(650) 493-5000","nvesom@pavir.org",{"type":30,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Celina Mei Yong","Principal Investigator",[43,45],{"name":44,"class":6},"Palo Alto Veterans Institute for Research",{"name":46,"class":47},"VA Palo Alto Health Care System","FED","100650004","empowering-veterans-in-research-effectively-using-virtual-engagement-tools-100650004",false,"NCT07741955","Empowering Veterans in Research Effectively Using Virtual Engagement Tools","EVERYVET (Empowering VEterans in Research effectivelY Using Virtual Engagement Tools): A Patient-Centered Study","EVERYVET","Inclusion Criteria (Aim 2):\n\n* Age 65 years or older\n* CHA2DS2-VASc Score of 3 or greater\n* Veteran receiving care within the VA Health Care System\n* Eligible to receive a mailed invitation through the parent VA Cooperative Studies cardiovascular trial recruitment process\n\nExclusion Criteria (Aim 2):\n\n* Any exclusion criterion applied by the parent VA Cooperative Studies cardiovascular trial\n* Documented preference to opt out of VA research mailings\n\nInclusion Criteria (Aim 1 Qualitative Interviews):\n\n* Age 18 years or older\n* Veteran receiving care at VAPAHCS\n* Recently invited (within 3 months) to participate in an existing cardiovascular clinical trial at VAPAHCS\n* Able to provide informed consent in English\n\nExclusion Criteria (Aim 1 Qualitative Interviews):\n\n* Cognitive impairment documented in the electronic health record\n* Inability to communicate in English at a level sufficient for qualitative interview participation\n\nInclusion Criteria (Aim 1 Beta-Testing and Aim 3):\n\n* Age 18 years or older\n* Veteran receiving care at VAPAHCS or a participating VA-CTC site\n* Able to view a brief video and complete a short survey in English\n\nExclusion Criteria (Aim 1 Beta-Testing and Aim 3):\n\n\\- Inability to communicate in English at a level sufficient for survey completion\n\nInclusion Criteria (Focus Groups):\n\n* VA study coordinator or trial investigator actively engaged in cardiovascular clinical trial recruitment at VAPAHCS or a VA-CTC site\n* Willing to participate in a 60-90 minute virtual focus group",true,"ALL","18 Years",{"count":60,"type":61},100000,"ESTIMATED","INTERVENTIONAL",[64],"NA","Cardiovascular disease is the leading cause of death among Veterans. Clinical trials are essential for developing better treatments, but Veterans remain underrepresented in these studies due to barriers including limited health literacy, lack of awareness, and mistrust. Current outreach approaches rely on either in-person physician conversations, which are limited by workforce constraints, or mailed letter invitations, which often fail to engage Veterans with limited health literacy. This study tests whether AI-generated video avatars can improve Veteran engagement in cardiovascular clinical trials.",[67,68],"Atrial Fibrillation (AF)","Cardiovascular Diseases",[70,71,72,73,74,75,76],"Veterans","Clinical Trial Recruitment","Cardiovascular Disease","Artificial Intelligence","Patient Engagement","Health Literacy","Virtual Outreach","NOT_YET_RECRUITING","2026-07-28",{"date":80,"type":81},"2026-08-03","ACTUAL",{"date":83,"type":61},"2026-07",{"date":85,"type":61},"2030-07",{"name":5,"class":6}]