[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653522":3},{"organization":4,"outcomesModule":7,"designInfo":43,"detailedDescription":51,"studyPopulation":42,"armGroups":52,"interventions":70,"overallOfficials":83,"centralContacts":88,"locations":96,"responsibleParty":110,"collaborators":42,"id":113,"slug":114,"hasResults":115,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":42,"eligibilityCriteria":119,"healthyVolunteers":120,"sex":121,"minAge":122,"maxAge":123,"enrollmentInfo":124,"targetDuration":42,"studyType":127,"phases":128,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":142,"whyStopped":42,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":152},{"fullName":5,"class":6},"Birjand University of Medical Sciences","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":42},[9],{"measure":10,"description":11,"timeFrame":12},"Change in Phase Angle (PhA) as a Cellular Health Index","Phase angle (PhA) measured using bioelectrical impedance analysis (Inbody770). PhA is calculated as the ratio of reactance (Xc) to resistance (R) and serves as an indicator of cellular health, membrane integrity, and cell function.","Measured at baseline (before intervention) and 48 hours after the last training session (week 8).",[14,17,20,23,26,30,33,36,39],{"measure":15,"description":16,"timeFrame":12},"Change in Serum Superoxide Dismutase (SOD)","Serum SOD level measured using ELISA kit. SOD is an antioxidant enzyme that catalyzes the dismutation of superoxide radical into oxygen and hydrogen peroxide.",{"measure":18,"description":19,"timeFrame":12},"Change in Upper Body Strength (Bench Press 1RM)","Maximum strength of the upper body measured using the bench press 1-repetition maximum (1RM) test.",{"measure":21,"description":22,"timeFrame":12},"Change in Lower Body Strength (Squat 1RM)","Maximum strength of the lower body measured using the squat 1-repetition maximum (1RM) test.",{"measure":24,"description":25,"timeFrame":12},"Change in Upper Body Muscular Endurance (Push-Up Test)","Upper body muscular endurance assessed using the push-up test. The number of correct push-ups performed within 60 seconds is recorded.",{"measure":27,"description":28,"timeFrame":29},"Change in Serum Glutathione Peroxidase (GPX)","Serum GPX level measured using ELISA kit. GPX is a selenium-containing enzyme that catalyzes the reduction of hydroperoxides.","Measured at baseline (before intervention) and 48 hours after the last training session (week",{"measure":31,"description":32,"timeFrame":29},"Change in Serum Catalase (CAT)","Serum CAT level measured using ELISA kit. CAT is an enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen.",{"measure":34,"description":35,"timeFrame":29},"Change in Serum Glutathione (GSH)","Serum glutathione level measured using ELISA kit. GSH is a major intracellular antioxidant that protects cells against oxidative damage.",{"measure":37,"description":38,"timeFrame":29},"Change in Serum Protein Carbonyl (PC)","Serum PC level measured using ELISA kit. PC is a marker of protein oxidation and oxidative damage to proteins.",{"measure":40,"description":41,"timeFrame":29},"Change in Serum Total Antioxidant Capacity (TAC)","Serum TAC level measured using ELISA kit. TAC reflects the overall capacity of the antioxidant system to neutralize free radicals.",null,{"allocation":44,"interventionModel":45,"interventionModelDescription":46,"primaryPurpose":47,"observationalModel":42,"timePerspective":42,"maskingInfo":48},"RANDOMIZED","PARALLEL","Participants will be randomly assigned to one of three parallel groups: resistance training, electrical muscle stimulation (EMS), or control. Each group will receive their respective intervention over an 8-week period, with assessments conducted at baseline and post-intervention.","BASIC_SCIENCE",{"masking":49,"maskingDescription":50,"whoMasked":42},"NONE","This is an open-label study. Due to the nature of the electrical muscle stimulation (EMS) intervention, which produces a noticeable physical sensation, blinding of participants and investigators is not feasible. Outcome assessors will be blinded to group allocation where possible.","This is a quasi-experimental, pretest-posttest, parallel-group clinical trial with three arms: resistance training, electrical muscle stimulation (EMS), and control. Forty-two overweight and obese women (BMI 25-35 kg\u002Fm², aged 35-45 years) will be randomly assigned to the three groups (n=14 each). Participants must meet the inclusion criteria including no history of cardiovascular disease, no pregnancy or lactation, no use of medications affecting muscle or fat mass, and no recent lower\u002Fupper extremity injuries.\n\nIntervention details:\n\nResistance training group: 8 weeks, 3 sessions\u002Fweek, 50 minutes each session. Exercises include upper body, back, abdominal, and lower body movements. Training intensity will progress from 60% of 1RM in week 1 to 85% of 1RM in week 8.\n\nEMS group: 8 weeks, 3 sessions\u002Fweek, 30 minutes each session. EMS will be applied to biceps brachii, abdominals, back, and quadriceps muscles using frequency of 35-70 Hz, pulse duration 100 μs, and pulse period 50 ms. Electrode size: 150 × 240 mm. Intensity will be progressively increased over the 8 weeks.\n\nControl group: No exercise intervention during the study period.\n\nOutcome measurements:\n\nPrimary outcome: Phase angle (PhA) measured using bioelectrical impedance analysis (Inbody770).\n\nSecondary outcomes: Serum levels of SOD, GPX, CAT, glutathione, PC, and TAC measured using ELISA kits. Upper body strength (bench press) and lower body strength (squat) measured via 1RM testing. Upper body endurance (push-up test) and lower body endurance (bodyweight squat test) measured in 60-second tests.\n\nStatistical analysis: Data will be analyzed using ANCOVA with pretest scores as covariates. Correlation between phase angle changes and oxidative stress markers will be assessed using Pearson's correlation coefficient. All analyses will be performed using SPSS, with significance set at p \\\u003C 0.05.",[53,59,65],{"label":54,"type":55,"description":56,"interventionNames":57},"Resistance Training","ACTIVE_COMPARATOR","Eight weeks of progressive resistance training, 3 sessions per week. Each session includes upper body, back, abdominal, and lower body exercises. Training intensity progresses from 60% of 1RM in week 1 to 85% of 1RM in week 8.",[58],"Other: Resistance Training",{"label":60,"type":61,"description":62,"interventionNames":63},"Electrical Muscle Stimulation (EMS)","EXPERIMENTAL","Eight weeks of electrical muscle stimulation training, 3 sessions per week. EMS applied to biceps brachii, abdominals, back, and quadriceps muscles using frequency of 35-70 Hz, pulse duration 100 μs, and pulse period 50 ms. Electrode size: 150 × 240 mm. Intensity progressively increased over 8 weeks.",[64],"Device: Electrical Muscle Stimulation",{"label":66,"type":6,"description":67,"interventionNames":68},"Control","No exercise intervention during the 8-week study period. Participants are asked to maintain their usual lifestyle and physical activity levels.",[69],"Other: No Intervention",[71,74,79],{"type":6,"name":54,"description":72,"armGroupLabels":73,"otherNames":42},"Progressive resistance training program including upper body (chest press), back (lat pulldown), abdominal (crunch), and lower body (squat) exercises. Performed 3 times per week for 8 weeks. Each session includes warm-up (10 min), main exercises (30 min), and cool-down (10 min). Intensity: 60-85% of 1RM, progressing weekly.",[54],{"type":75,"name":76,"description":77,"armGroupLabels":78,"otherNames":42},"DEVICE","Electrical Muscle Stimulation","Electrical muscle stimulation applied to biceps brachii, abdominals, back, and quadriceps muscles using a commercial EMS device. Parameters: frequency 35-70 Hz, pulse duration 100 μs, pulse period 50 ms, electrode size 150 × 240 mm. Performed 3 times per week for 8 weeks, 15 minutes per session. Intensity progressively increased based on participant tolerance.",[60],{"type":6,"name":80,"description":81,"armGroupLabels":82,"otherNames":42},"No Intervention","Participants in the control group receive no exercise intervention during the 8-week study period.",[66],[84],{"name":85,"affiliation":86,"role":87},"Mohsen Mohammadnia Ahmadi, PhD","university of birjand","PRINCIPAL_INVESTIGATOR",[89,94],{"name":90,"role":91,"phone":92,"phoneExt":42,"email":93},"Mohsen Ahmadi Mohammadnia, Assistant Proffessor","CONTACT","0985631026917","m.m.ahmadi2005@gmail.com",{"name":95,"role":91,"phone":92,"phoneExt":42,"email":93},"Mohsen Ahmadi Mohammadnia, Assistant proffesor",[97],{"facility":98,"status":42,"city":99,"state":100,"zip":101,"country":102,"countryCode":103,"cosmosGeoPoint":104,"geoPoint":109,"contacts":42},"Faculty of Sport Sciences, University of Birjand","Birjand","South Khorasan Province","9717434765","Iran","IR",{"type":105,"coordinates":106},"Point",[107,108],59.22114,32.86628,{"lat":108,"lon":107},{"type":87,"investigatorFullName":111,"investigatorTitle":112,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"Mohsen mohammadnia ahmadi","University of Birjand","100653522","ems-vs-resistance-training-in-overweight-women-100653522",false,"NCT07787286","EMS vs. Resistance Training in Overweight Women","Comparison of the Effect of Eight Weeks of Electrical Muscle Stimulation (EMS) Versus Resistance Training on Oxidative Stress Indicators and Cellular Health Index in Overweight and Obese Women","Inclusion Criteria:\n\n* Healthy non-menopausal women aged 35 to 45 years\n\nBody mass index (BMI) between 25 and 35 kg\u002Fm²\n\nSimilar menstrual cycle pattern\n\nNo pregnancy or lactation\n\nNo continuous medication affecting fat or muscle mass (based on health and fitness questionnaire)\n\nNo history of cruciate ligament injury or other upper\u002Flower extremity injuries in the past 6 months\n\nNo history of heart attack or acute cardiovascular disease\n\nNo use of medications (glucocorticoids, beta-blockers, alcohol) or antioxidant supplements that could interfere with study results\n\nExclusion Criteria:\n\n* Inability to complete the intervention program\n\nAbsence from more than three consecutive training sessions\n\nFailure to comply with the study protocol\n\nDevelopment of any medical condition during the study period that contraindicates continued participation",true,"FEMALE","35 Years","45 Years",{"count":125,"type":126},42,"ESTIMATED","INTERVENTIONAL",[129],"NA","This study aims to compare the effects of eight weeks of resistance training versus electrical muscle stimulation (EMS) on oxidative stress indicators and cellular health index in overweight and obese women aged 35-45 years. Forty-two participants will be randomly assigned to three groups: resistance training, EMS, and control. The resistance training group will perform progressive resistance exercises three times per week for eight weeks. The EMS group will receive electrical muscle stimulation on biceps, abdominal, back, and quadriceps muscles three times per week for eight weeks. The control group will receive no intervention. Oxidative stress markers including superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT), glutathione, protein carbonyl (PC), and total antioxidant capacity (TAC) will be measured from blood samples. Cellular health will be assessed using phase angle (PhA) derived from bioelectrical impedance analysis. Upper and lower body muscular strength and endurance will also be evaluated. All measurements will be taken at baseline and 48 hours after the last training session. The primary outcome is change in phase angle. Secondary outcomes include changes in oxidative stress markers and physical performance.",[132],"Obesity & Overweight",[134,135,54,136,137,138,139,140,141],"Obesity","Overweight","Electric Stimulation Therapy","Oxidative Stress","Phase Angle","Superoxide Dismutase","Catalase","Body Composition","NOT_YET_RECRUITING","2026-08-22",{"date":145,"type":146},"2026-08-26","ACTUAL",{"date":148,"type":126},"2026-09-15",{"date":150,"type":126},"2026-11-25",{"name":5,"class":6},1]