[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648895":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":28,"responsibleParty":51,"collaborators":54,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":10,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Josip Juraj Strossmayer University of Osijek","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Normotensive Controls",null,"Adults aged 18 years or older with normal office blood pressure according to the European Society of Hypertension (ESH) guidelines and without a history of hypertension or antihypertensive treatment.",{"label":13,"type":10,"description":14,"interventionNames":10},"Adults With Newly Diagnosed Untreated Primary Hypertension","Adults aged 18 years or older with newly diagnosed, previously untreated primary hypertension according to the European Society of Hypertension (ESH) guidelines and no prior use of antihypertensive medication.",[16],{"name":17,"affiliation":18,"role":19},"Ana Stupin, MD, PhD","Faculty of Medicine Osijek, Josip Juraj Strossmayer of Osijek","STUDY_CHAIR",[21,25],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","+38531512800","ana.stupin@mefos.hr",{"name":26,"role":22,"phone":10,"phoneExt":10,"email":27},"Ivana Jukić, MD, PhD","ivana.jukic@mefos.hr",[29],{"facility":30,"status":31,"city":32,"state":10,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Faculty of Medicine Osijek","RECRUITING","Osijek","31000","Croatia","HR",{"type":37,"coordinates":38},"Point",[39,40],18.6942,45.55066,{"lat":40,"lon":39},[43,44,45,48],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},{"name":26,"role":22,"phone":23,"phoneExt":10,"email":27},{"name":46,"role":47,"phone":10,"phoneExt":10,"email":10},"Ivana Tolj, MD, PhD","PRINCIPAL_INVESTIGATOR",{"name":49,"role":50,"phone":10,"phoneExt":10,"email":10},"Marko Stupin, MD, PhD","SUB_INVESTIGATOR",{"type":47,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Ines Drenjancevic","Full Professore Tenure, Head of Department of Physiology and Immunology, Faculty of Medicine Osijek",[55],{"name":56,"class":6},"Osijek University Hospital","100648895","endothelial-extracellular-vesicles-as-biomarkers-of-endothelial-activation-in-adults-with-newly-diagnosed-hypertension-100648895",false,"NCT07728630","Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Adults With Newly Diagnosed Hypertension","Endothelial Extracellular Vesicles as Biomarkers of Blood Pressure-Induced Endothelial Activation in Adults With Newly Diagnosed Untreated Hypertension","HYPER-endoEV-a","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Ability and willingness to provide written informed consent.\n* Normotensive individuals or individuals with newly diagnosed, previously untreated primary hypertension, classified according to the European Society of Hypertension (ESH) guidelines.\n* Ability to comply with all study procedures.\n\nExclusion Criteria:\n\n* Secondary hypertension.\n* Previous treatment with antihypertensive medication.\n* History of cardiovascular disease (except newly diagnosed primary hypertension in the hypertensive group).\n* Diabetes mellitus.\n* Chronic kidney disease.\n* Cerebrovascular disease.\n* Peripheral arterial disease.\n* Acute or chronic inflammatory or infectious disease.\n* Active malignancy.\n* Pregnancy or breastfeeding.\n* Current use of oral contraceptives, hormone replacement therapy, or medications known to affect endothelial function.\n* Inability or unwillingness to provide informed consent.",true,"ALL","18 Years",{"count":69,"type":70},80,"ESTIMATED","OBSERVATIONAL","Hypertension is associated with endothelial dysfunction, an early event in the development of cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation and vascular injury; however, their relationship with blood pressure and microvascular endothelial function in untreated hypertension remains insufficiently understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive adults and adults with newly diagnosed, untreated primary hypertension. In addition, the study will investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and established circulating biomarkers of endothelial activation. The findings may improve understanding of the role of EEVs in early hypertension and support their potential use as non-invasive biomarkers of endothelial dysfunction and cardiovascular risk.",[74,75],"Hypertension","Endothelial Function",[74,77,78,79,80,81,82,83,84,85,86],"Primary Hypertension","Endothelial Dysfunction","Endothelial Extracellular Vesicles","Extracellular Vesicles","Endothelial Activation","Biomarkers","Microvascular Function","Laser Doppler Flowmetry","Post-Occlusive Reactive Hyperemia","Vascular Function","2026-07-22",{"date":89,"type":90},"2026-07-27","ACTUAL",{"date":92,"type":90},"2026-05-01",{"date":94,"type":70},"2029-09-30",{"name":5,"class":6},1]