[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648844":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":27,"responsibleParty":45,"collaborators":49,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Josip Juraj Strossmayer University of Osijek","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Normotensive Controls",null,"Children and adolescents with normal blood pressure according to current pediatric hypertension guidelines.",{"label":13,"type":10,"description":14,"interventionNames":10},"Newly Diagnosed Untreated Primary Hypertension","Children and adolescents with newly diagnosed, previously untreated primary hypertension according to current pediatric hypertension guidelines.",[16],{"name":17,"affiliation":18,"role":19},"Ivana Jukić, MD, PhD","Faculty of Medicine Osijek, Josip Juraj Strossmayer of Osijek","STUDY_CHAIR",[21,25],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","+38531512800","medicina@mefos.hr",{"name":26,"role":22,"phone":23,"phoneExt":10,"email":24},"Ana Stupin, MD, PhD",[28],{"facility":29,"status":30,"city":31,"state":10,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Faculty of Medicine Osijek","RECRUITING","Osijek","31000","Croatia","HR",{"type":36,"coordinates":37},"Point",[38,39],18.6942,45.55066,{"lat":39,"lon":38},[42],{"name":43,"role":22,"phone":10,"phoneExt":10,"email":44},"Mia Damašek, MD","mdmiadamasek@gmail.com",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ines Drenjancevic","Full Professor Tenure, Head of the Department of Physiology and Immunology, Faculty of Medicine Osijek",[50],{"name":51,"class":6},"Osijek University Hospital","100648844","endothelial-extracellular-vesicles-as-biomarkers-of-endothelial-activation-in-children-with-newly-diagnosed-hypertension-100648844",false,"NCT07728643","Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension","Endothelial Extracellular Vesicles as Biomarkers of Blood Pressure-Induced Endothelial Activation in Children With Newly Diagnosed Untreated Primary Hypertension","HYPER-endoEV-c","Inclusion Criteria:\n\n* Children and adolescents aged 6-17 years.\n* Written informed consent from a parent or legal guardian and assent from the participant when appropriate.\n* Normotensive status or newly diagnosed, previously untreated primary hypertension according to current pediatric hypertension guidelines.\n* Ability to comply with study procedures.\n\nExclusion Criteria:\n\n* Secondary hypertension.\n* Previous antihypertensive treatment.\n* Congenital heart disease or other significant cardiovascular disease.\n* Diabetes mellitus.\n* Chronic kidney disease.\n* Autoimmune or chronic inflammatory disease.\n* Acute infection at the time of enrollment.\n* Malignancy.\n* Use of medications known to affect endothelial function.\n* Inability to comply with study procedures.",true,"ALL","6 Years","17 Years",{"count":65,"type":66},80,"ESTIMATED","OBSERVATIONAL","Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their role in pediatric hypertension remains poorly understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive children and children with newly diagnosed, untreated primary hypertension. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury in pediatric hypertension and support the development of non-invasive biomarkers for early cardiovascular risk assessment.",[70,71,72],"Pediatric Hypertension","Primary Hypertension","Endothelial Dysfunction",[70,74,71,75,72,76,77,78,79,80],"Childhood Hypertension","Endothelial Extracellular Vesicles","Endothelial Activation","Biomarkers","Microvascular Function","Laser Doppler Flowmetry","Cardiovascular Risk","2026-07-22",{"date":83,"type":84},"2026-07-27","ACTUAL",{"date":86,"type":84},"2026-04-01",{"date":88,"type":66},"2029-09-30",{"name":5,"class":6},1]