[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652313":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":49,"centralContacts":53,"locations":62,"responsibleParty":79,"collaborators":35,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":35,"eligibilityCriteria":87,"healthyVolunteers":84,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":35,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":106,"whyStopped":35,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"The University of Texas Health Science Center, Houston","OTHER",[8,15,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Active rTMS Combined with Strong Cognitive Training","EXPERIMENTAL","Participants will receive active H-coil delivered rTMS, as well as strong cognitive training in each treatment visit for up to 10 treatment visits within about 2 weeks. In each visit, there are three rTMS sessions and each of them is followed by a cognitive training session and a rest period, which allows the inter-rTMS-session interval to be about 30 minutes. The cognitive training includes several cognitive computer games that are meant to improve the speed and accuracy of performance--strong cognitive training is intended to significantly enhance cognitive functions.",[13,14],"Device: Active rTMS","Behavioral: Strong Cognitive Training",{"label":16,"type":10,"description":17,"interventionNames":18},"Active rTMS Combined with Weak Cognitive Training","Participants will receive active H-coil delivered rTMS, as well as weak cognitive training in each treatment visit for up to 10 treatment visits within about 2 weeks. In each visit, there are three rTMS sessions and each of them is followed by a cognitive training session and a rest period, which allows the inter-rTMS-session interval to be about 30 minutes. The cognitive training includes several cognitive computer games that are meant to improve the speed and accuracy of performance--weak cognitive training may yield only modest improvements in cognitive functions.",[13,19],"Behavioral: Weak Cognitive Training",{"label":21,"type":10,"description":22,"interventionNames":23},"Sham rTMS Combined with Strong Cognitive Training","Participants will receive sham H-coil delivered rTMS, as well as strong cognitive training in each treatment visit for up to 10 treatment visits within about 2 weeks. In each visit, there are three rTMS sessions and each of them is followed by a cognitive training session and a rest period, which allows the inter-rTMS-session interval to be about 30 minutes. In case of sham TMS, no actual magnetic stimulation will occur, still the participant hears the TMS sound and a skin sensation. The cognitive training includes several cognitive computer games that are meant to improve the speed and accuracy of performance--strong cognitive training is intended to significantly enhance cognitive functions.",[14,24],"Device: Sham rTMS",{"label":26,"type":10,"description":27,"interventionNames":28},"Sham rTMS Combined with Weak Cognitive Training","Participants will receive sham H-coil delivered rTMS, as well as weak cognitive training in each treatment visit for up to 10 treatment visits within about 2 weeks. In each visit, there are three rTMS sessions and each of them is followed by a cognitive training session and a rest period, which allows the inter-rTMS-session interval to be about 30 minutes. In case of sham TMS, no actual magnetic stimulation will occur, still the participant hears the TMS sound and a skin sensation. The cognitive training includes several cognitive computer games that are meant to improve the speed and accuracy of performance--weak cognitive training may yield only modest improvements in cognitive functions.",[24,19],[30,36,41,45],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"DEVICE","Active rTMS","Active H-coil delivered rTMS sessions will be given three times per treatment visit for up to 10 visits within about 2 weeks. There are about 30 minutes breaks between adjacent TMS sessions. Each TMS session takes about 3 to 4 minutes to complete.",[9,16],null,{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":35},"BEHAVIORAL","Strong Cognitive Training","For the cognitive training sessions, patients will be asked to play cognitive computer games involving processing speed tasks for about 15 to 30 minutes. Strong cognitive training is intended to significantly enhance cognitive functions",[9,21],{"type":31,"name":42,"description":43,"armGroupLabels":44,"otherNames":35},"Sham rTMS","Sham H-coil delivered rTMS sessions will be given three times per treatment visit for up to 10 visits within about 2 weeks. There are about 30 minutes breaks between adjacent TMS sessions. Each TMS session takes about 3 to 4 minutes to complete. In case of sham TMS, no actual magnetic stimulation will occur, still the participant hears the TMS sound and a skin sensation.",[21,26],{"type":37,"name":46,"description":47,"armGroupLabels":48,"otherNames":35},"Weak Cognitive Training","For the cognitive training sessions, patients will be asked to play cognitive computer games involving processing speed tasks for about 15 to 30 minutes. Weak cognitive training may yield only modest improvements in cognitive functions.",[16,26],[50],{"name":51,"affiliation":5,"role":52},"Xiaoming Du, PhD","PRINCIPAL_INVESTIGATOR",[54,59],{"name":55,"role":56,"phone":57,"phoneExt":35,"email":58},"Bhim M Adhikari","CONTACT","713-486-2740","bhim.m.adhikari@uth.tmc.edu",{"name":51,"role":56,"phone":60,"phoneExt":35,"email":61},"443-882-9717","Xiaoming.Du@uth.tmc.edu",[63],{"facility":5,"status":35,"city":64,"state":65,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"Houston","Texas","77054","United States","US",{"type":70,"coordinates":71},"Point",[72,73],-95.36327,29.76328,{"lat":73,"lon":72},[76,77],{"name":51,"role":56,"phone":60,"phoneExt":35,"email":61},{"name":78,"role":56,"phone":57,"phoneExt":35,"email":58},"Bhim Adhikari",{"type":52,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"Xiaoming Du","Assistant Professor","100652313","enhancing-brain-connectivity-in-schizophrenia-through-neuromodulation-study-3-100652313",false,"NCT07772349","Enhancing Brain Connectivity in Schizophrenia Through Neuromodulation (Study 3)","Inclusion Criteria:\n\n1. Male and female ages between ages 18-60 years\n2. Ability to give written informed consent (age 18 or above)\n3. Diagnosed with schizophrenia-spectrum disorder and Evaluation to Sign Consent (ESC) above 10.\n\nExclusion Criteria:\n\n1. Inability to sign informed consent.\n2. Any history of seizures.\n3. Any acute and unstable major medical illnesses that may affect normal brain functioning. Examples of these conditions include, but not limited to, recent stroke, seizure, history of significant head trauma, CNS infection or tumor, other significant brain neurological conditions (As this is a study of medical comorbidity, most medical conditions, once stable, are not exclusion criteria).\n4. Taking \\> 400 mg clozapine\u002Fday and not on anti-seizure medication(s) with sufficient dose.\n5. Failed TMS screening questionnaire.\n6. Significant alcohol or other drug use (substance abuse within 1 month or substance dependence history within 6 months and having substance usage within 1 month) other than nicotine or marijuana dependence.\n7. A history of thrombosis, family history of thrombosis, or medical conditions that may lead to a hypercoagulable state (increased chance to develop blood clots)\n8. Woman who is pregnant (child-bearing potential but not on contraceptive and missing menstrual period; or by self-report; or by positive urine pregnancy test).\n9. History of head injury with loss of consciousness over 10 minutes; history of brain surgery\n10. Cannot refrain from using alcohol and\u002For marijuana 24 hours or more prior to experiments.\n11. Students and employees currently involved with our lab (lab employees and personnel will be excluded from the study to avoid possible coercion or possible appearance of coercion, or chance of breach of privacy and confidentiality).\n12. For MRI, unable to undergo MRI scanning due to metallic devices or objects (cardiac pacemaker or neurostimulator, some artificial joints, metal pins, surgical clips, or other implanted metal parts) or claustrophobic to the scanner.","ALL","18 Years","60 Years",{"count":92,"type":93},120,"ESTIMATED","INTERVENTIONAL",[96],"NA","The aim of the study is to assess the treatment effects of deep active repetitive transcranial magnetic stimulation (rTMS) with H4 coil combined with cognitive training for improving frontal white matter microstructural integrity in patients with schizophrenia spectrum disorder (SSD).",[99],"Schizophrenia",[101,102,103,104,105],"Transcranial magnetic stimulation","schizophrenia","white matter","connectivity","myelination","NOT_YET_RECRUITING","2026-08-13",{"date":109,"type":110},"2026-08-19","ACTUAL",{"date":112,"type":93},"2026-10-01",{"date":114,"type":93},"2029-05-01",{"name":5,"class":6},1]