[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100447168":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":37,"locations":43,"responsibleParty":62,"collaborators":65,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":31,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":31,"overallStatus":45,"whyStopped":31,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"active, then sham Intermittent Theta Burst Stimulation (iTBS) over DLPFC","EXPERIMENTAL","This arm will first receive active iTBS stimulation and then sham iTBS over the left dorsolateral prefrontal cortex (DLPFC).",[13,14],"Device: active intermittent Theta Burst Stimulation (iTBS)","Device: sham intermittent Theta Burst Stimulation (iTBS)",{"label":16,"type":10,"description":17,"interventionNames":18},"sham, then active intermittent Theta Burst Stimulation (iTBS) over DLPFC","This arm will first receive sham iTBS (i.e., with the TMS coil in the placebo orientation) and then active iTBS stimulation over the left dorsolateral prefrontal cortex (DLPFC).",[13,14],[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","active intermittent Theta Burst Stimulation (iTBS)","iTBS is a brief stimulation of a part of the brain with a magnetic field that passes through the scalp and skull safely. It is FDA-approved as a treatment for psychological conditions including depression; however, this device is not approved for the treatment of adults with patients with schizophrenia. This research study is using iTBS off label in SCZ patients to examine research questions.",[9,16],[26],"Transcranial Magnetic Stimulation",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"sham intermittent Theta Burst Stimulation (iTBS)","Sham TBS over the left DLPFC will be performed using a Cool-B65 A\u002FP TMS coil, designed to support blinded clinical trials. Specifically, when the coil is placed in the \"P\" position (i.e. the \"placebo\" position), only a very small amount of current is induced in tissue, thus preventing the activation of cortical neurons.",[9,16],null,[33],{"name":34,"affiliation":35,"role":36},"Fabio Ferrarelli, MD, PhD","University of Pittsbrugh","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":31,"email":42},"Sabine Janssen","CONTACT","412-246-6114","janssensa@upmc.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Pittsburgh","Pennsylvania","15213","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-79.99589,40.44062,{"lat":55,"lon":54},[58],{"name":59,"role":40,"phone":60,"phoneExt":31,"email":61},"Fabio Ferrarelli","4128641668","ferrarellif@upmc.edu",{"type":63,"investigatorFullName":59,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"SPONSOR_INVESTIGATOR","Associate Professor",[66],{"name":67,"class":68},"National Institute of Mental Health (NIMH)","NIH","100447168","enhancing-prefrontal-oscillations-and-working-memory-in-early-course-schizophrenia-100447168",false,"NCT05102929","Enhancing Prefrontal Oscillations and Working Memory in Early-course Schizophrenia","Enhancing Prefrontal Oscillatory Activity and Working Memory Performance With Noninvasive Brain Stimulation in Early-course Schizophrenia","REDOCS","Inclusion Criteria:\n\n1. ages 18-40 years\n2. DSM diagnoses of Schizophrenia Spectrum Axis I disorders\n3. a duration of less than three years from beginning of psychosis, defined by report of symptoms and\u002For history of treatment, based on clinical guidelines employed in our UPMC psychoses clinics in Pittsburgh.\n\nExclusion Criteria:\n\n1. DSM intellectual developmental disorder\n2. significant head injury\n3. medical illness affecting brain structure or function\n4. significant neurologic disorder (e.g. seizure disorder)\n5. personal history or family history of epilepsy\n6. inability to provide informed consent\n7. concussion with loss of consciousness (LOC) greater than 10 minutes\n8. history of electroconvulsive therapy\n9. diabetes with associated seizures, loss of sensation\u002Fweakness in arms or legs, or momentary LOC\n10. pregnancy or postpartum (\\\u003C6 weeks after delivery or miscarriage), as determined by self-report\n11. a psychotic illness with a temporal relation to substance use or head injury.\n12. current or past co-morbidity for alcohol or psychoactive substance dependence\n13. substance abuse, other than cannabis and\u002For alcohol, within the past one year","ALL","18 Years","40 Years",{"count":81,"type":82},75,"ESTIMATED","INTERVENTIONAL",[85],"NA","This study will investigate the effects of intermittent Theta Burst Stimulation (iTBS) on natural oscillatory frequency of the dorsolateral prefrontal cortex (DLPFC) and working memory in early-course schizophrenia (EC-SCZ). Transcranial magnetic stimulation (TMS) will be used to evoke oscillatory activity, and EEG will record the responses of EC-SCZ participants. A working memory task will also be incorporated in order to determine how DLPFC natural frequency (NF) is related to working memory performance. iTBS (active or sham) will be administered, then the oscillatory activity of DLPFC and working memory performance will be reassessed. The overarching goal is to determine whether iTBS can acutely enhance the oscillatory activity of the DLPFC and to evaluate the relationship between changes in the DLPFC and working memory performance.",[88],"Schizophrenia","2026-08-07",{"date":91,"type":92},"2026-08-11","ACTUAL",{"date":94,"type":92},"2021-11-05",{"date":96,"type":82},"2026-10",{"name":59,"class":6},1]